P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation [0.03%]
帕金醇通过依赖p53诱导的铁死亡缓解四氯化碳致肝纤维化和肝星状细胞活化
Ling Wang,Zili Zhang,Mengmeng Li et al.
Ling Wang et al.
Ferroptosis is recently reported as a new mode of regulated cell death. Its essential characteristics are disturbed redox homeostasis, overloaded iron, and increased lipid peroxidation. However, the role of ferroptosis in liver fibrosis rem...
MicroRNA-107 regulates anesthesia-induced neural injury in embryonic stem cell derived neurons [0.03%]
miR-107调节麻醉引起的胚胎干细胞分化神经元损伤
Jun Dan Jiang,Xiao Chun Zheng,Feng Yi Huang et al.
Jun Dan Jiang et al.
Ketamine, though widely used in pediatric anesthesia, may induce cortical neurotoxicity in young patients. This study focused on an in vitro model of rat brain embryonic stem cell (ESC)-derived neurons to investigate the effects of microRNA...
Anticancer activity of thymol: A literature-based review and docking study with Emphasis on its anticancer mechanisms [0.03%]
丁香酚抗肿瘤作用：基于文献的综述及对接研究及其抗肿瘤机制探讨
Muhammad T Islam,Abul B R Khalipha,Rajat Bagchi et al.
Muhammad T Islam et al.
This review aims to summarize the anticancer effects of the natural monoterpene phenol derivative of cymenethymol and its derivatives as well as further molecular docking study to correlate the interaction of thymol and biomacromolecules th...
Vitamin E intestinal absorption: Regulation of membrane transport across the enterocyte [0.03%]
维生素E的肠道吸收：跨肠细胞转运的调节
Emmanuelle Reboul
Emmanuelle Reboul
Vitamin E is an essential molecule for our development and health. It has long been thought that it was absorbed and transported through cellular membranes by a passive diffusion process. However, data obtained during the past 15 years show...
Gertraud Burger,Matus Valach
Gertraud Burger
Mitochondria are the sandbox of evolution as exemplified most particularly by the diplonemids, a group of marine microeukaryotes. These protists are uniquely characterized by their highly multipartite mitochondrial genome and systematically...
UCK2 upregulation might serve as an indicator of unfavorable prognosis of hepatocellular carcinoma [0.03%]
UCK2上调可能是肝细胞癌不良预后的指示器
Shuo Yu,Xu Li,Xingjun Guo et al.
Shuo Yu et al.
Uridine-cytidine kinases (encoded by UCK1, UCKL1, and UCK2) catalyze the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP). In this study, using data from the Cancer Genome Atlas (TCGA),...
MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway [0.03%]
沉默MCL1基因通过抑制PI3K/AKT信号通路促进胶质瘤细胞衰老及凋亡
Dong-Mei Wu,Xiao-Wu Hong,Xin Wen et al.
Dong-Mei Wu et al.
Glioma is known to be the most prevalent primary brain tumor. In recent years, there has been evidence indicating myeloid cell leukemia-1 (MCL1) plays a role in brain glioblastoma. Therefore, the present study was conducted with aims of exp...
Are DNA damage response kinases a target for the differentiation treatment of acute myeloid leukemia? [0.03%]
DNA修复激酶是急性髓系白血病分化治疗的靶点吗？
Rosa Pennisi,Jacopo Albanesi,Paolo Ascenzi et al.
Rosa Pennisi et al.
Acute myeloid leukemia (AML) is a genetically heterogeneous malignancy characterized by the expansion of hematopoietic stem/progenitor cells (HPCs) blocked at different stages of maturation/differentiation. The poor outcome of AMLs necessit...
Massive mitochondrial DNA content in diplonemid and kinetoplastid protists [0.03%]
双极体和动基体类纤毛虫的巨量线粒体DNA含量
Julius Lukeš,Richard Wheeler,Dagmar Jirsová et al.
Julius Lukeš et al.
The mitochondrial DNA of diplonemid and kinetoplastid protists is known for its suite of bizarre features, including the presence of concatenated circular molecules, extensive trans-splicing and various forms of RNA editing. Here we report ...
MicroRNA-146a sponge therapy suppresses neointimal formation in rat vein grafts [0.03%]
microRNA-146a海绵疗法可抑制大鼠静脉移植术后内膜增生
Bo-Jun Cao,Xiao-Wen Wang,Lei Zhu et al.
Bo-Jun Cao et al.
The long-term failure of vein grafts due to neointimal hyperplasia remains a difficult problem in cardiovascular surgery. Exploring novel approaches to prevent neointimal hyperplasia is important. MicroRNA-146a (miR-146a) plays an essential...