Angiotensin II confers resistance to apoptosis in cardiac myofibroblasts through the AT1/ERK1/2/RSK1 pathway [0.03%]
血管紧张素II通过AT1/ERK1/2/RSK1通路赋予心脏肌成纤维细胞抗凋亡能力
Wenfeng Cai,Shuping Zhong,Fuchun Zheng et al.
Wenfeng Cai et al.
Myofibroblast apoptosis is essential for normal resolution of wound repair, including cardiac infarction repair. Impaired cardiac myofibroblast (CMF) apoptosis is associated with excessive extracellular matrix (ECM) deposition, which could ...
Paracoccus denitrificans Oxidative Phosphorylation: Retentions, Gains, Losses, and Lessons En Route to Mitochondria [0.03%]
亚硝化帕拉塞克菌氧化磷酸化的保留、获得、损失及其对线粒体演化的启示
Stuart J Ferguson
Stuart J Ferguson
There are many similarities between the oxidative phosphorylation apparatus of mitochondria and those found in the cytoplasmic membranes of alpha-proteobacteria, exemplified by Paracocus denitrificans. These similarities are reviewed here a...
MicroRNA-98 attenuates cardiac ischemia-reperfusion injury through inhibiting DAPK1 expression [0.03%]
微小核糖核酸-98通过抑制DAPK1表达减轻心肌缺血再灌注损伤
Chang-Lin Zhai,Guan-Min Tang,Gang Qian et al.
Chang-Lin Zhai et al.
Cardiovascular ischemic disease is a large class of diseases that are harmful to human health. The significant role of microRNAs (miRNAs) in terms of controlling cardiac injury has been reported in latest studies. MiR-98 is very important i...
Viraj Muthye,Dennis V Lavrov
Viraj Muthye
Mitochondria require ~1,500 proteins for their maintenance and proper functionality, which constitute the mitochondrial proteome (mt-proteome). Although a few of these proteins, mostly subunits of the electron transport chain complexes, are...
Circulating Oxidized Low-Density Lipoprotein is a Strong Risk Factor for the Early Stage of Coronary Heart Disease [0.03%]
循环氧化低密度脂蛋白是冠心病早期阶段的强危险因素
Qiang Zhang,Yongshun Ai,Huiqiu Dong et al.
Qiang Zhang et al.
This study aimed to detect the circulating oxidized low-density lipoprotein (ox-LDL) levels of controls and patients with stable angina pectoris (SAP), unstable angina pectoris (UAP), and acute myocardial infarction (AMI) and also to invest...
Phytol as an anticarcinogenic and antitumoral agent: An in vivo study in swiss mice with DMBA-Induced breast cancer [0.03%]
植物醇作为抗致癌和抗肿瘤剂的体内研究：DMBA诱导的瑞士鼠乳腺癌模型中的研究
Marcus Vinícius Oliveira Barros de Alencar,Muhammad Torequl Islam,Rosália Maria Torres de Lima et al.
Marcus Vinícius Oliveira Barros de Alencar et al.
Phytol (PHY) (3,7,11,15-tetramethylhexadec-2-en-1-ol) exhibits various pharmacological properties including toxicity and cytotoxicity, and exerts antitumor activity. Owing to the urgent need of new pharmaceutical formulations for breast can...
Mitonuclear epistasis, genotype-by-environment interactions, and personalized genomics of complex traits in Drosophila [0.03%]
线粒体与核基因互作、基因型与环境互作以及复杂性状的个性化组学研究——以果蝇为例
David M Rand,Jim A Mossman,Lei Zhu et al.
David M Rand et al.
Mitochondrial function requires the coordinated expression of dozens of gene products from the mitochondrial genome and hundreds from the nuclear genomes. The systems that emerge from these interactions convert the food we eat and the oxyge...
Padmakrishnan C Jayakrishnan,Easwer H Venkat,Girish M Ramachandran et al.
Padmakrishnan C Jayakrishnan et al.
Sphere formation is an indicator of tumor aggressiveness independent of the tumor grade; however, its relation to progression-free survival (PFS) is less known. This study was designed to assess the neurosphere forming ability among low gra...
Ushio Kikkawa
Ushio Kikkawa
Protein kinase C (PKC) is activated by 1,2-diacylglycerol as a second messenger in the signaling mechanism coupled with the hydrolysis of membrane inositol phospholipids, although it was not found by screening for a 1,2-diacylglycerol-depen...
Long non-coding RNA SNHG16 has Tumor suppressing effect in acute lymphoblastic leukemia by inverse interaction on hsa-miR-124-3p [0.03%]
长非编码RNA SNHG16通过与hsa-miR-124-3p的互作在急性淋巴细胞白血病中发挥抑癌作用
Tianxin Yang,Xing Jin,Jianping Lan et al.
Tianxin Yang et al.
Acute lymphoblastic leukemia (ALL) is one of the deadly forms of childhood cancers in the world. In the present study, we used both in vitro and in vivo models to evaluate the functional mechanisms of a long noncoding RNA (lncRNA), small nu...