Fatemeh Khadangi,Angelo Azzi
Fatemeh Khadangi
α-Tocopherol is the only tocopherol that has been shown to prevent the human deficiency disease Ataxia with Isolated Vitamin E Deficiency (AVED), and thus it is the only one that, for humans, can be called vitamin E. Vitamin E in addition ...
Detection of malignancy-associated phosphoproteome changes in human colorectal cancer induced by cell surface binding of growth-inhibitory galectin-4 [0.03%]
由生长抑制型半乳糖凝集素-4诱导的结直肠癌细胞表面结合物中与恶性转化相关的磷酸化蛋白质组变化的检测
Malwina Michalak,Uwe Warnken,Martina Schnölzer et al.
Malwina Michalak et al.
Emerging evidence on efficient tumor growth regulation by endogenous lectins directs interest to determine on a proof-of-principle level the range of information on alterations provided by full-scale analysis using phosphoproteomics. In our...
MicroRNA-101 protects bladder of BOO from hypoxia-induced fibrosis by attenuating TGF-β-smad2/3 signaling [0.03%]
微小核糖核酸-101通过减弱TGF-β-smad2/3信号转导来保护BOO膀胱免受缺氧诱导的纤维化损伤
Ning Wang,Liujian Duan,Jie Ding et al.
Ning Wang et al.
Bladder outlet obstruction is a common disease, which always evokes urinary bladder wall remodeling significantly. It has been suggested that bladder outlet obstruction can make the bladder progression from inflammation to fibrosis, and hyp...
Giovanna De Simone,Fabio Polticelli,Silvio Aime et al.
Giovanna De Simone et al.
In the "Hypothesis" paper entitled "Lanthanides-Based Catalysis in Eukaryotes" (IUBMB Life 2018 Nov;70(11):1067-1075), we analyzed the possibility that Ce3+ -dependent methanol dehydrogenases (MDHs) could be found not only in archaea and ba...
Natural forms of vitamin E and metabolites-regulation of cancer cell death and underlying mechanisms [0.03%]
天然维生素E及其代谢产物对癌细胞死亡的调控作用及机制研究
Qing Jiang
Qing Jiang
The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E rega...
Orange is the new black: Kinases are the new master regulators of tumor suppression [0.03%]
橙色是新的黑色：激酶是肿瘤抑制的新调控因子
Elvira An,John Brognard
Elvira An
For many decades, kinases have predominantly been characterized as oncogenes and drivers of tumorigenesis, because activating mutations in kinases occur in cancer with high frequency. The oncogenic functions of kinases relate to their roles...
Tilorone activates NK cells and cytotoxic lymphocytes that kill HLA-negative tumor cells [0.03%]
Tilorone激活杀死人类白细胞抗原阴性肿瘤细胞的自然杀伤细胞和细胞毒性淋巴细胞
Tatiana N Sharapova,Elena A Romanova,Lidia P Sashchenko et al.
Tatiana N Sharapova et al.
Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells ...
Cyclin-dependent kinase 9 promotes cervical cancer development via AKT2/p53 pathway [0.03%]
周期蛋白依赖性激酶9通过AKT2/p53信号通路促进宫颈癌的发展
Junfen Xu,Shanshan Xu,Yifeng Fang et al.
Junfen Xu et al.
Aberrant activation of cyclin-dependent kinase 9 (CDK9) is widespread in human cancers. However, the underlying mechanisms of CDK9 activation and the therapeutic potential of CDK9 inhibition in cervical cancer remain largely unknown. Here, ...
Correlation of abrin-mediated inhibition of protein synthesis and apoptosis [0.03%]
Abrin介导的蛋白质合成抑制和细胞凋亡之间的相关性研究
Vinita Tiwari,Anjali A Karande
Vinita Tiwari
The plant toxin, abrin, a type-II ribosome inactivating protein, is extremely lethal, the human fatal dose being ~1 μg/kg body weight. Abrin has been classified as an agent for bioterrorism, which is of concern. Conversely, the high toxic ...
Loss of m6 A on FAM134B promotes adipogenesis in porcine adipocytes through m6 A-YTHDF2-dependent way [0.03%]
FAM134B 去甲基化通过 m6A-YTHDF2 依赖性方式促进猪脂肪细胞的脂肪生成
Min Cai,Qing Liu,Qin Jiang et al.
Min Cai et al.
N6 -methyladenosine (m6 A) mRNA modification plays an important role in adipogenesis, but its role on single gene remains unexplored. Family with Sequence Similarity 134, Member B (FAM134B) is a cis-Golgi transmembrane protein that known to...