Adverse fetal and neonatal impact of war conflicts during pregnancy: A systematic review [0.03%]
孕期战争冲突对胎儿和新生儿的不良影响：系统回顾
Blanca Riquelme-Gallego,Lucía Ramos-Soberbio,Ester Leno-Duran et al.
Blanca Riquelme-Gallego et al.
The aim of the present study was to establish the fetal and neonatal impact of war conflicts during pregnancy. A systematic review was conducted according to The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) gu...
Hypoxia inducible factor 3-alpha promotes a malignant phenotype in colorectal cancer cells [0.03%]
缺氧诱导因子3-α促进结肠癌细胞的恶性表型
Alejandro Lopez-Mejia,Angela Patricia Moreno-Londoño,Gabriela Fonseca Camarillo et al.
Alejandro Lopez-Mejia et al.
Colorectal cancer (CRC) is the third most common cancer worldwide. Hypoxia is a hallmark of the tumor microenvironment, and cellular adaptation to it is primarily mediated by the family of Hypoxia-inducible factors (HIFs) HIF-1α, HIF-2α, ...
Structure-function relationships between the human bitter taste receptor TAS2R38 and propylthiouracil: An in-silico investigation [0.03%]
人类苦味受体TAS2R38与丙硫氧嘧啶之间的结构-功能关系：一项计算机模拟研究
Gowtham Subramanian,Vinithra Ponnusamy,Janaranjani Murugesan et al.
Gowtham Subramanian et al.
Taster categorisation uses bitter thiourea compounds like propylthiouracil (PROP) and phenylthiocarbamide (PTC), which are frequently associated with amino acid alterations at positions 49, 262 and 296 in human taste 2 receptor member 38 (h...
Genomic landscaping of receptor tyrosine kinase ALK with highly frequent rearrangements in cancers [0.03%]
高度频繁的癌症受体酪氨酸激酶ALK基因组景观研究
Wei Ye,Wen-Bin Ou
Wei Ye
Anaplastic lymphoma kinase (ALK) fusion tyrosine kinases (TKs) are commonly found in various cancers and are considered as promising targets for therapy due to their intricate biological processes. However, the reasons for the higher freque...
Possible new mechanisms of primary drug resistance in NSCLC with EGFR mutation treated with Osimertinib [0.03%]
奥希替尼治疗EGFR突变阳性非小细胞肺癌原发耐药的可能机制研究
Lujing Shao,Tong Li,Xinyan Jia et al.
Lujing Shao et al.
In this study, a patient with lung adenocarcinoma harboring an EGFR mutation exhibited primary resistance to the targeted EGFR inhibitor Osimertinib after 2 months of treatment. As the disease advanced, further genetic analysis revealed the...
Case Reports
IUBMB life. 2025 Feb;77(2):e70002. DOI:10.1002/iub.70002 2025
Zinc finger protein 169 promotes tumor progress of hepatocellular cancer via up-regulating cyclin-dependent kinase 19 [0.03%]
锌指蛋白169通过上调周期素依赖性激酶19促进肝细胞癌进展
Chaoquan Hu,Aizier Ainiwaer,Ying Lu et al.
Chaoquan Hu et al.
Hepatocellular carcinoma (HCC) ranks among the most prevalent types of cancer globally. Zinc finger protein 169 (ZNF169) holds significant importance as a transcription factor, yet its precise function in HCC remains to be elucidated. This ...
Deciphering the senescence-based tumoral heterogeneity and characteristics in pancreatic cancer: Results from parallel bulk and single-cell transcriptome data [0.03%]
基于胰腺癌平行组学泛癌及单细胞转录数据分析肿瘤衰老异质性和特征
Yeting Lu,Shuo Han,Jing Hu et al.
Yeting Lu et al.
The prevalent intra- and intertumoral heterogeneity results in undesirable prognosis and therapy failure of pancreatic cancer, potentially resulting from cellular senescence. Herein, integrated analysis of bulk and single-cell RNA-seq profi...
CDKN3 as a key regulator of G2M phase in triple-negative breast cancer: Insights from multi-transcriptomic analysis [0.03%]
CDKN3作为三阴性乳腺癌G2M期的关键调节因子：来自多转录组分析的见解
Haodi Ma,Yirui Dong,Jiayu Zheng et al.
Haodi Ma et al.
Triple-negative breast cancer (TNBC) remains a significant global health challenge, emphasizing the need for precise identification of patients with specific therapeutic targets and those at high risk of metastasis. This study aimed to iden...
The up-regulation of RIPK3 mediated by ac4C modification promotes oxidative stress-induced granulosa cell senescence by inhibiting the Nrf2/HO-1 pathway [0.03%]
表观修饰ac4C通过上调RIPK3促进氧化应激诱导的颗粒细胞衰老的新机制研究
Wanjun Zhang,Jiahao Zhang,Yile Zhang et al.
Wanjun Zhang et al.
Abnormality of granulosa cells (GCs) is the critical cause of follicular atresia in premature ovarian failure (POF). RIPK3 is highly expressed in GCs derived from atretic follicles. We focus on uncovering how RIPK3 contributes to ovarian GC...