Ischemic preconditioning attenuates ischemia/reperfusion-induced acute kidney injury dependent on mitochondrial protease CLPP [0.03%]
缺血预处理通过线粒体蛋白酶CLPP依赖性途径减轻再灌注急性肾损伤
Wenjia Xie,Lingqi Gao,Xinyan Gu et al.
Wenjia Xie et al.
Ischemic preconditioning (IPC) is a phenomenon in which brief periods of ischemia trigger protective mechanisms that alleviate subsequent ischemia-reperfusion injury (IRI), although the precise protective mechanism remains unclear. This stu...
Yeast models for Charcot-Marie-Tooth disease-causing aminoacyl-tRNA synthetase alleles reveal the cellular basis of disease [0.03%]
酵母模型对于揭示Charcot-Marie-Tooth疾病致病的氨基酸-tRNA合成酶等位基因的细胞基础的应用
Maria Mahmood,Emma Little,Nicole Girard et al.
Maria Mahmood et al.
Charcot-Marie-Tooth disease (CMT) is a genetically diverse hereditary disorder that affects the motor and sensory nerves, impacting about 1 in 2500 people. It can be inherited through autosomal dominant (AD), autosomal recessive (AR), or X-...
Downregulation of KLF9 alleviates tubulointerstitial fibrosis by modulating FABP4-mediated lipid accumulation [0.03%]
KLF9的下调通过调节FABP4介导的脂质积累来缓解管间质纤维化
Lin Zhang,Xin-Yu Wang,Ting Tian et al.
Lin Zhang et al.
Tubulointerstitial fibrosis (TIF) is a significant determinant in the pathogenesis of chronic kidney disease (CKD) and is commonly concurrent with lipid infiltration in the renal tubules. Nonetheless, the precise regulatory mechanism of thi...
OTUB1 facilitates lipid accumulation in oxLDL-induced THP-1 macrophages by stabilizing scavenger receptor-A [0.03%]
OTUB1通过稳定清道夫受体A促进oxLDL诱导的THP-1巨噬细胞脂质积聚
Xianwei Huang,Yixuan Liu,Xiong Liu et al.
Xianwei Huang et al.
The formation of foam cells triggered by excessive lipid accumulation within macrophages is a hallmark of atherosclerosis development. Scavenger receptor-A (SR-A) is a key regulator of lipid uptake by macrophages during oxidized low-density...
Conventional and innovative approaches to black fungi control for stone heritage preservation [0.03%]
用于石质文化遗产保护的防治黑真菌的传统方法和创新方法
Domenico Celi,Massimiliano Marvasi,Brunella Perito
Domenico Celi
Black Meristematic Fungi (BMF) are characterized by a thick melanized cell wall and an isodiametric cellular expansion. BMF represent one of the most damaging groups of microorganisms causing the deterioration of outdoor exposed stone monum...
Upstream transcription factor 1 suppresses laryngeal squamous cell carcinoma progression through transcriptional activation of junctional adhesion molecule 3 [0.03%]
上游转录因子1通过粘附分子3的转录激活抑制喉鳞状细胞癌的发展
Yue Jia,Jiaojiao Liu,Yichen Lou et al.
Yue Jia et al.
Laryngeal squamous cell carcinoma (LSCC) exhibits aggressive growth, frequent recurrence, and a notable resistance to existing treatments. Building upon prior discoveries that identified junctional adhesion molecule 3 (JAM3) as a critical t...
The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells [0.03%]
cGAS-STING相关的signature通过调节多种免疫细胞影响结直肠癌的预后
Yunlong Li,Xunliang Jiang,Hui Cao et al.
Yunlong Li et al.
The cGAS-STING signaling pathway has emerged as a critical player in the immune response against cancer, including colorectal adenocarcinoma (COAD). Understanding the impact of this pathway on COAD at multiple omics levels is crucial for ad...
Histone demethylase LSD1 promotes castration-resistant prostate cancer by causing widespread gene expression derangements [0.03%]
组蛋白去甲基化酶LSD1通过引起广泛的基因表达异常促进前列腺癌病人的病情复发
Haiying Li,Xiujie Fan,Xiuxiu Fang et al.
Haiying Li et al.
Lysine-specific demethylase 1 (LSD1), a histone demethylase crucial for embryonic development and tissue differentiation, has an undefined role in prostate cancer (PCa), especially castration-resistant PCa. The present study represents a pi...
Purification and validation of asparaginyl-tRNA synthetase heterodimer with indistinguishable subunits [0.03%]
具有无法区分的亚基的天冬酰胺-tRNA合成酶异二聚体的纯化与验证
Ingrid Vallee,Ryan Shapiro,Xiang-Lei Yang
Ingrid Vallee
Oligomerization can influence the stability and activity of a protein. The majority of enzymes, including aminoacyl-tRNA synthetases, become catalytically active upon forming homodimers. Residues located at the dimerization interface are hi...
Enhanced HER2 status detection in breast and gastric cancers using surrogate DNA methylation markers [0.03%]
利用替代DNA甲基化标志物提高乳腺癌和胃癌中HER2状态的检测率
Yajie Hu,Siyu Liu,Chunhui Cui et al.
Yajie Hu et al.
There is a limited understanding of specific DNA methylation patterns associated with HER2 overexpression in breast and gastric cancers. Here we aim to solve the problem using inferred DNA methylation markers. DNA methylation data from The ...