Progress in Nanocarriers-Based Approaches for the Delivery of Tyrosine Kinase Inhibitors in Bone Cancer: Trends and Prospects [0.03%]
基于纳米载体的酪氨酸激酶抑制剂递送在骨癌治疗中的进展：趋势和前景
Dexin Xu,Wenbin Zhang,Yinping Pan et al.
Dexin Xu et al.
Bone cancer remains a life-threatening malignancy predominantly affecting pediatric and adolescent populations, with tyrosine kinase inhibitors (TKIs) emerging as promising therapeutic agents; however, their clinical utility is limited by p...
RETRACTION: Blockade of High Mobility Group Box 1 Involved in the Protective of Curcumin on Myocardial Injury in Diabetes In Vivo and In Vitro [0.03%]
撤稿：体内外姜黄素通过阻断高迁移率族盒蛋白1保护糖尿病心肌损伤研究
X. Yan, P. Xu, L. Zhou, J. Lu, H. Tang, Y. Zheng and H. Cao, "Blockade of High Mobility Group Box 1 Involved in the Protective of Curcumin on Myocardial Injury in Diabetes In Vivo and In Vitro," IUBMB Life 72, no. 5 (2020): 931-941, https:/...
ZEB1 Contributes to Drug Resistance Through Canonical Wnt Signaling in Lung Cancer [0.03%]
ZEB1通过经典Wnt信号转导途径介导肺癌耐药性
Hubo Shi,Min Wang,Qianqian Zhao et al.
Hubo Shi et al.
Lung cancer is a severe malignant disease and causes plenty of deaths each year. The survival and prognosis are disappointing for patients with recurrence or metastasis. This is partially due to the lack of mechanisms underlying lung cancer...
Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data Reveals Cellular Senescence-Related Signatures Predicting New Potential Therapeutic Drugs in Hepatic Ischemia-Reperfusion Injury [0.03%]
单细胞和批量RNA测序数据的综合分析揭示了与肝缺血再灌注损伤相关衰老相关的特征，预测新的潜在治疗药物
Junlin Chen,Huaming Huang,Zhi Lu et al.
Junlin Chen et al.
Three human bulk RNA sequencing (RNA-seq) datasets from the GEO database, comprising liver tissues from 76 patients with hepatic ischemia-reperfusion injury (IRI) and 80 controls, were analyzed to identify differentially expressed genes rel...
Bioinformatics-Based Exploration of LMO4-Regulated Hippo Pathway to Reverse Adriamycin Resistance in Breast Cancer [0.03%]
基于生物信息学的LMO4调控Hippo通路逆转乳腺癌阿霉素耐药性研究
Yue Wu,Jiahui Gao,Zejie Su et al.
Yue Wu et al.
The development of acquired drug resistance in breast cancer (BC) significantly compromises treatment efficacy and patient survival, yet the underlying molecular mechanisms remain completely understood. In this study, we investigated the ro...
CircZNF418 Prevents Intervertebral Disc Degeneration by Targeting the HuR/SIRT6 Axis to Protect Against Oxidative Stress-Induced Ferroptosis and Senescence [0.03%]
环状RNA CircZNF418 通过靶向调控 HuR/SIRT6 轴抵抗氧化应激诱导的铁死亡和衰老从而防止椎间盘退变
Ke Wei,Daming Feng,Dongdong Fan et al.
Ke Wei et al.
Intervertebral disc degeneration (IVDD) is a common degenerative disorder affecting the spine. Ferroptosis and cellular senescence are key pathological features driving IVDD progression, but the mechanisms involved in their regulation remai...
Cannabidiol Suppresses EMT in Pancreatic Cancer via Inhibition of MALAT1 lncRNA and PI3K/Akt/mTOR Signaling Pathway [0.03%]
大麻二酚通过抑制MALAT1长链非编码RNA和PI3K/Akt/mTOR信号通路抑制胰腺癌的上皮间质转化
Na Young Kim,Young Yun Jung,Jae-Young Um et al.
Na Young Kim et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive metastasis and poor response to chemotherapy, largely driven by epithelial-mesenchymal transition (EMT) and chemokine signaling. Cannabidiol (CBD), a non-psychoactive ph...
RING Finger Protein 4 (RNF4) Reduces Nonalcoholic Fatty Liver Disease Accumulation by Promoting the SUMOylation of HIF-2α and Regulating the PPARα Signaling Pathway [0.03%]
RING指蛋白4通过促进HIF-2α的SUMO化和调节PPARα信号通路减少非酒精性脂肪肝病的积累
Li Yang,Qing Ni,Yan He et al.
Li Yang et al.
RING finger protein 4 (RNF4) acts as a SUMO-targeted ubiquitin ligase, principally regulating protein stability and playing a crucial role in liver injury, inflammatory, and cholestatic diseases. In spite of this, it is unclear how it contr...
The Synergic Inhibition of Wilforlide A With Cisplatin in Lung Cancer Is Mediated Through Caspase-3 and NFκB Signaling [0.03%]
萎-forllide A与顺铂在肺癌中的协同抑制作用通过caspase-3和NFκB信号通路介导
Zhonglu Peng,Xiang Xiao,Xinyi Lu et al.
Zhonglu Peng et al.
Lung cancer is a malignant disease in the respiratory system and accounts for hundreds of thousands of deaths each year. Cisplatin is the first-line drug in the clinic for lung cancer. However, drug resistance and side effects are becoming ...
CircROBO2 Orchestrates Osimertinib Resistance Through miR-625-5p/PDGFB-Mediated MAPK Activation in Non-Small Cell Lung Cancer [0.03%]
Circular RNA CircROBO2通过miR-625-5p/PDGFB介导的MAPK活化调控非小细胞肺癌中奥希替尼耐药性
Miao He,Jiang-Ying Cai,Ying-Ying Wang et al.
Miao He et al.
The emergence of acquired resistance to osimertinib represents a formidable therapeutic challenge in the management of non-small cell lung cancer (NSCLC). While circular RNAs (circRNAs) have been increasingly recognized as crucial modulator...