Advancing Therapeutic Strategies for Nonsense-Related Diseases: From Small Molecules to Nucleic Acid-Based Innovations [0.03%]
nonsense相关疾病的治疗策略研究从小分子到核酸创新疗法的发展
Davide Ricci,Ilenia Cruciata,Ignazio Fiduccia et al.
Davide Ricci et al.
Nonsense mutations in gene coding regions introduce an in-frame premature termination codon (PTC) in the mRNA transcript, resulting in the early termination of translation and the production of a truncated, nonfunctional protein. The absenc...
Discovery and Validation of a New Biomarker Integrating Ferroptosis and Glycolysis-Related Genes in Bladder Cancer [0.03%]
整合铁死亡和糖酵解相关基因的新的生物标志物在膀胱癌中的发现与验证
Chenyang Wang,Yuncong Shu,Jiaqi Shan et al.
Chenyang Wang et al.
Bladder cancer (BCa) is a highly invasive tumor with few successful therapies, and its unfavorable prognosis mainly stems from late diagnosis and resistance to treatment. Ferroptosis is a type of non-apoptotic cell death characterized by ir...
Proline- and Serine-Rich Coiled-Coil 1 Predicts an Unfavorable Prognosis and Exhibits Oncogenic Activities in Breast Cancer [0.03%]
脯氨酸和丝氨酸丰富型卷曲螺旋蛋白1通过致癌作用预测乳腺癌预后不良
Xin Jin,Qingqing Zhao,Xiaowen Hao et al.
Xin Jin et al.
Proline- and serine-rich coiled-coil 1 (PSRC1) has been implicated in various cancers, yet its role in breast cancer (BRCA) remains incompletely understood. Here, we employed the UALCAN database to explore PSRC1 expression in BRCA and obtai...
Contrast-Induced Acute Kidney Injury is Modulated by Circadian CLOCK/NRF2 Pathway [0.03%]
生物钟CLOCK/NRF2通路调节造影剂引起的急性肾损伤事件
Shuqing Yang,Xinxin Xu,Lulu Wang et al.
Shuqing Yang et al.
Numerous kidney functions exhibit substantial circadian oscillations, such as renal blood flow, glomerular filtration rate, tubular reabsorption function, and erythropoietin production. The onset and the injury of acute kidney injury caused...
Hermansky-Pudlak Syndrome: From Molecular Pathogenesis to Targeted Therapies [0.03%]
赫尔曼斯基-普杜拉综合征：从分子发病机制到靶向治疗
Francesca Tondi,Roberta Annamaria Cirsmaru,Chiara Conti et al.
Francesca Tondi et al.
Hermansky-Pudlak syndrome (HPS) is a rare inherited disorder caused by defects in lysosome-related organelles (LROs) in various tissues, including platelets, melanocytes, and endothelial cells. Key features of HPS include oculocutaneous alb...
The combination of midkine inhibitor with Lenvatinib amplifies the suppression of hepatocellular carcinoma [0.03%]
.midkine抑制剂与仑伐替尼联用可增强对肝细胞癌的抑制作用
Xue Chen,Shujun Guo,Qilin Meng et al.
Xue Chen et al.
Hepatocellular carcinoma (HCC) accounts for 75%-85% of primary liver cancer cases globally. HCC patients have a poor prognosis because of tumor metastasis and medication resistance; thus, novel therapy targets and techniques are needed. By ...
Modulation of Osteogenic Differentiation by CYBB in Osteoporotic Models [0.03%]
CYBB调节骨形成在骨质疏松症模型中的作用
Zhaodong Wang,Chen Xu,Yajun Liu et al.
Zhaodong Wang et al.
Osteoporosis (OP) is a prevalent systemic skeletal disease characterized by increased bone fragility and fracture risk. Identifying factors that influence osteogenic differentiation in OP is crucial. We screened genes associated with OP fro...
Correction to "Upstream Transcription Factor 1 Suppresses Laryngeal Squamous Cell Carcinoma Progression Through Transcriptional Activation of Junctional Adhesion Molecule 3" [0.03%]
“上游 transcription factor 1通过转录激活连接粘附分子 3抑制喉鳞状细胞癌进展”的勘误函
Published Erratum
IUBMB life. 2025 May;77(5):e70021. DOI:10.1002/iub.70021 2025
Therapeutic Potential of Translational Readthrough at Disease-Associated Premature Termination Codons From Tumor Suppressor Genes [0.03%]
肿瘤抑制基因疾病相关提前终止密码子的转录读码-through治疗潜力
Leire Torices,Caroline E Nunes-Xavier,Rafael Pulido
Leire Torices
Tumor suppressor genes are frequently targeted by mutations introducing premature termination codons (PTC) in the protein coding sequence, both in sporadic cancers and in the germline of patients with cancer predisposition syndromes. These ...
Synergistic Effects of Epirubicin-Vorinostat-Pimozide Drug Cocktail on Proliferation, Stemness, Invasiveness, and Fatty Acid Metabolism in Breast Cancer Cells [0.03%]
表柔比星-伏立诺他-匹莫齐德药物联合治疗对乳腺癌细胞增殖、干性、侵袭性和脂肪酸代谢的协同作用
Thirukumaran Kandasamy,Shilpi Sarkar,Azar Zochedh et al.
Thirukumaran Kandasamy et al.
Chemotherapeutic treatments for breast cancer are often associated with severe toxicity due to the requirement of high concentrations of the drugs for efficacy. The combination of chemotherapy drugs along with repurposed drugs offers a prom...