Troyee Das,Byapti Ghosh,Arijita Sarkar et al.
Troyee Das et al.
PIWI-interacting RNAs (piRNAs) have emerged as key gene regulators in diverse biological processes. Earlier believed to be germline-specific, these endogenous small non-coding RNAs (~26-32 nucleotides) have now been identified to play an ac...
SNORA33 Promotes Clear Cell Renal Cell Carcinoma Development and Resistance to Sunitinib Through Triggering the JAK/STAT Pathway [0.03%]
SNORA33通过激活JAK/STAT途径促进透明细胞肾细胞癌的发生和发展及苏尼替尼耐药性
Jiajia Sun,Shuo Zhao,Xiaochen Ren et al.
Jiajia Sun et al.
Accumulating evidence has confirmed that snoRNAs exert a role in a variety of cancers; however, the role of SNORA33 in clear cell renal cell carcinoma (ccRCC) remains unclear. This study was aimed at elucidating the role and mechanism of SN...
Exploring Macrophage Contribution to Vascular Calcification in Atherosclerosis [0.03%]
动脉粥样硬化血管钙化形成中巨噬细胞的作用机制探讨
Siarhei A Dabravolski,Mikhail A Popov,Olga N Maltseva et al.
Siarhei A Dabravolski et al.
Vascular calcification (VC) is a significant pathological feature of atherosclerosis, contributing to cardiovascular morbidity and mortality, particularly in populations with diabetes and chronic kidney disease (CKD). This review examines t...
Analysis of miRNA Expression Profiles in High Cholesterol Diet-Induced MASH Progression: Potential Effect of α-Tocopherol [0.03%]
高胆固醇饮食诱导的MASH进展中miRNA表达特征分析及α-生育酚的潜在干预效应
Tugce Demirel-Yalciner,Bengu Cetinkaya,Kazim Yalcin Arga et al.
Tugce Demirel-Yalciner et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD), defined by fat accumulation in more than 5% of hepatocytes, is a common metabolic syndrome worldwide. However, 30%-40% of MAFLD cases progress to metabolic dysfunction-associated...
Tissue Factor Driven Coagulation and Inflammation in Lung Injury: Insights From In Vitro and In Vivo Models [0.03%]
组织因子驱动的肺损伤凝血和炎症：来自体外和体内模型的启示
Aleena Varughese,Akarsha Balnadupete,Fathimath Muneesa Moideen et al.
Aleena Varughese et al.
Lung injury and fibrosis involve a complex interplay between inflammation and coagulation, with tissue factor (TF/CF-III/Thromboplastin/CD142) acting as a crucial mediator. Despite its known role in initiating the extrinsic coagulation casc...
17-Oxo-DHA Potentiates Macrophage Efferocytosis via Nrf2/HO-1-Mediated Biosynthesis of Specialized Pro-Resolving Mediators [0.03%]
17-氧代-docosahexaenoic酸通过Nrf2/血红素氧合酶-1介导的特殊性促解决介质生物合成促进巨噬细胞摄取 apoptotic 细胞
Ibrahim Isot,Doga Demir Yangi,Tugce Demirel-Yalciner et al.
Ibrahim Isot et al.
Phagocytic engulfment of apoptotic cells, particularly neutrophils by macrophages, known as efferocytosis, is crucial in preventing secondary necrosis and promoting tissue repair. 17-Oxo-DHA, an electrophilic metabolite of docosahexaenoic a...
DYRK1A Overexpression Drives Muscle Wasting by Impeding Myogenesis via a USP7-Axin1-β-Catenin Regulatory Axis in Mice [0.03%]
DYRK1A过表达通过USP7-Axin1-β-catenin调节轴干扰肌细胞生成驱动肌肉萎缩研究小鼠模型中的相关机制
Mei Lu,Xiaohui Li,Lin Ma et al.
Mei Lu et al.
Muscle wasting, characterized by loss of muscle mass and strength, severely impacts patient quality of life and is associated with numerous chronic diseases and aging. The molecular mechanisms are complex, involving protein synthesis/degrad...
Pan-Cancer Analysis Identifies DIP2B as a Potential Biomarker That Inhibits Kidney Renal Clear Cell Carcinoma Progression [0.03%]
泛癌症分析鉴定出DIP2B是可能抑制肾透明细胞癌发展的生物标志物
Yang Chen,Yao Guo,Ankang Hu et al.
Yang Chen et al.
Disco interacting protein 2 homolog B (DIP2B) is a protein-coding gene implicated in various biological processes, including embryonic development, cell cycle regulation, DNA repair, and transcriptional regulation. While its precise role in...
Unveiling Gamma-Interferon-Inducible Lysosomal Thiol Reductase (IFI30) as a Regulator of Macrophage Polarization and Prognostic Biomarker by Multi-Transcriptome Analysis in Cervical Cancer [0.03%]
多转录组分析揭示γ干扰素诱导的溶酶体硫醇还原酶（IFI30）是宫颈癌巨噬细胞极化调控因子和预后生物标志物
Wei Wang,Yuhua Deng,Yinglin Feng et al.
Wei Wang et al.
Cervical cancer remains a significant challenge to global health, necessitating the development of reliable clinical prognostic models to predict patient survival outcomes with accuracy. This study aims to develop an mRNA signature model ba...
PLEKHF1 Induces Mitochondrial Dysfunction to Inhibit Osteosarcoma Growth and Metastasis [0.03%]
PLEKHF1通过诱导线粒体功能障碍抑制成骨肉瘤生长和转移
Jun Wan,Xinyan Cai,Zhan Liao et al.
Jun Wan et al.
Osteosarcoma (OS) is an uncommon malignancy with stagnant survival rates over the past four decades and early-stage metastasis, predominantly affecting children and adolescents. This study identified significant metabolic differences betwee...