A New Treatment Strategy for Lung Cancer With HDAC and Wnt/β-Catenin Pathway Inhibitors [0.03%]
用于肺癌的新治疗策略——组蛋白去乙酰化酶和Wnt/β-catenin通路抑制剂
Elif Erturk,Oguzhan Akgun,Yaren Yildiz et al.
Elif Erturk et al.
Lung cancer is a type of cancer with high morbidity and mortality rates worldwide. The overall survival rate of lung cancer patients is low due to a lack of therapeutic options. Recently, the combination of histone deacetylase (HDAC) inhibi...
Underlining the Molecular Mechanism of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease in Lipid Metabolism by Combining Multiple Sets of Data Sets [0.03%]
通过联合多种数据集阐释脂代谢在非酒精性脂肪肝与冠心病分子机制中的作用
Wei Zheng,Shouhao Wang,Huafang Wang et al.
Wei Zheng et al.
Nonalcoholic fatty liver disease (NAFLD) is closely associated with coronary artery disease (CAD); however, their shared genetic traits and molecular mechanisms in lipid metabolism remain unclear. In this study, we identified that the diffe...
SPP1 Regulates SASP via the p53 Signaling Pathway to Affect ALI Progression [0.03%]
SPP1通过p53信号通路调节衰老相关分泌表型以影响ALI进程
Congcong Yuan,Shilong Zhao,Wentao Ma et al.
Congcong Yuan et al.
Acute lung injury (ALI) is a condition with acute respiratory failure caused by various factors, characterized by severe hypoxemia and diffuse alveolar damage, involving multiple cytokines and signaling pathways. This study investigates the...
Fungi and Myxomycetes of the Tehuacán-Cuicatlán Biosphere Reserve, Mexico: A Comprehensive Review and Future Perspectives [0.03%]
墨西哥特瓦坎-库里亚坦生物圈保护区地衣和黏菌的研究综述及未来展望
Julio Mena-Portales,Yordanis Pérez-Llano,Marco Antonio Vásquez-Dávila et al.
Julio Mena-Portales et al.
The Tehuacán-Cuicatlán Biosphere Reserve in Mexico, spanning approximately 10,000 km2, is crucial for conserving arid and semi-arid ecosystems, as it hosts unique endemic species and complex ecological interactions. Despite their environm...
Single-Cell Profiling of the Microenvironment in High-Risk Neuroblastoma [0.03%]
高危神经母细胞瘤微环境的单细胞测序分析
Yuxuan Xu,Jinsheng Ding,Zhenyu Shi et al.
Yuxuan Xu et al.
Although tumor biology and treatment of neuroblastoma (NB) have substantially advanced, the clinical outcomes of patients with high-risk NB (HR-NB) still remain unsatisfactory. Increasing evidence suggests that targeting the tumor microenvi...
Modulation of PPAR-α and PPAR-γ Influences Cardiomyocyte Growth and Cardiac Remodeling [0.03%]
PPAR-α和PPAR-γ的调节影响心肌细胞增殖及心脏重塑
Qinkao Xuan,Jin Li,Zexiong Feng et al.
Qinkao Xuan et al.
Peroxisome proliferator-activated receptors (PPARs), particularly PPAR-α and PPAR-γ, are key regulators of cardiac energy metabolism and have been implicated in cardiac remodeling. However, their roles in cardiomyocyte proliferation and h...
Euryhaline Black Yeasts From the Arabian Gulf: Descriptions of Salinomyces qatarensis sp. nov. and Hortaea werneckii Genotypic Variations [0.03%]
来自阿拉伯湾的广盐性黑酵母菌：Salinomyces qatarensis 新型种和Hortaea werneckii 代表新基因型的分类描述
Rashmi Fotedar,Polona Zalar,Amina Al Malaki et al.
Rashmi Fotedar et al.
The Arabian Gulf surrounding Qatar is an oligotrophic marine environment characterized by extreme conditions, such as increased water temperatures and high salinity compared to other semi-enclosed seas, such as the Mediterranean Sea. Thirty...
Squalene: A High-Value Compound for COVID-19 Vaccine Adjuvants and Beyond Pathways, Production Strategies, and Market Potential [0.03%]
角鲨烯：新冠疫苗佐剂的高附加值化合物及市场前景：路径、生产策略与潜力分析
Dileep Dasari,Reeta Rani Singhania,Shashi Kant Bhatia et al.
Dileep Dasari et al.
Squalene, a naturally occurring triterpene, has gained significant attention due to its critical role as an adjuvant in COVID-19 vaccines and its broad applications in pharmaceuticals, cosmetics, and nutraceuticals. This review explores the...
Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS/YARS1 Depletion [0.03%]
酪氨酸和苯丙氨酸激活神经元DNA修复，但对全局转录产生相反影响，并且成年雌性小鼠能够抵抗TyrRS / YARS1耗尽的影响
Megha Jhanji,Ashita Bhan,Colin Arrowood et al.
Megha Jhanji et al.
Serum tyrosine and phenylalanine levels increase during aging and age-associated disorders. We previously showed that tyrosyl-tRNA synthetase (TyrRS/YARS1) is reduced in Alzheimer's Disease (AD) brains, and tyrosine and phenylalanine decrea...
Emanuele Vitale,Davide Ricci,Federica Corrao et al.
Emanuele Vitale et al.
Over 7000 rare diseases have been described, collectively affecting 350 million people worldwide. Most of these conditions result from nonsense mutations, representing approximately 10% of all genetic mutations associated with human inherit...