Integrated Multiomics Analysis and Mendelian Randomization Identify SIRT1 as a Pivotal Aging-Associated Gene in Meningioma [0.03%]
整合多组学分析和孟德尔随机化确定SIRT1是脑膜瘤中的一个关键衰老相关基因
Guangyu Du,Daikang Xu,Jingxian Sun et al.
Guangyu Du et al.
Meningiomas (MGMs) are the most prevalent benign intracranial tumors in adults, with incidence markedly increasing with age, underscoring the need to explore aging-associated molecular mechanisms. In this study, we integrated transcriptomic...
4-Methylumbelliferone Sensitizes Breast Cancer Spheroids to Chemotherapeutic Treatment With Epirubicin: New Perspectives for Pharmacological Repositioning [0.03%]
4-甲基香豆素素使乳腺癌细胞球对表柔比星化疗增敏：药物再定位的新视角
Daiana Luján Vitale,Antonella Icardi,Paolo Rosales et al.
Daiana Luján Vitale et al.
Chemoresistance remains a significant hurdle in breast cancer treatment. To address this, we explored the therapeutic potential of combining epirubicin, an anthracycline commonly associated with the development of resistance in cancer cells...
Critical Contribution of Various Signaling Pathways in the Development of Drug Resistance in Colorectal Cancer: An Update [0.03%]
结直肠癌药物耐药发生发展中多种信号通路的关键作用：进展报告
Mehran Molavand,Maryam Majidinia,Bahman Yousefi
Mehran Molavand
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide, with drug resistance being a major challenge in limiting the available treatment options. This review focuses on the signaling pathways (Hedgehog, Hippo...
CDCA4/SERTAD1/E2F1 Facilitates Lung Adenocarcinoma Progression by Inhibiting PINK1/Parkin-Mediated Mitophagy [0.03%]
CDCA4/SERTAD1/E2F1通过抑制PINK1/Parkin介导的线粒体自噬促进肺腺癌进展
Jianlong Tan,Jufen Wang,Weidong Zhang et al.
Jianlong Tan et al.
Cell division cycle-associated protein 4 (CDCA4) has the potential to indicate lung adenocarcinoma (LUAD) development, but its regulatory role in mitophagy remains unclear. This study aimed to elucidate the mitophagy regulation and therapeu...
Nuclear Aggregates of Polyamines-DNA Complexes Imply a Genomic Electronic Circuit [0.03%]
多胺-DNA复合物的核聚集体暗示了基因组电子电路
Giuseppe Iacomino,Gianluca Picariello,Luciano D&#x;Agostino
Giuseppe Iacomino
This review introduces a novel conceptual framework, which suggests that key DNA functions, including rapid gene activation, conformational changes, and chromosomal structuring, could be regulated by an electronic-like circuit. The winding ...
Gastric Cancer Cell-Derived Exosomes Induce Macrophage M2 Polarization by Delivering circSMARCC1 to Promote Gastric Cancer Progression [0.03%]
胃癌细胞来源的外泌体通过递送circSMARCC1诱导M2型巨噬细胞极化促进胃癌进展
Cao Zhang,Jingjing Ye,Qingsong Guan et al.
Cao Zhang et al.
Exosomes, the cargo of circRNA, are crucial in cancer cell-tumor microenvironment communication. circSMARCC1 exerts a pro-tumor effect. However, this role has not been previously reported in gastric cancer (STAD). This study explores the ro...
All-Trans Retinoic Acid as a Predictor and Therapeutic Agent for Vascular Calcification [0.03%]
全反式维甲酸可作为血管钙化的预测和治疗标志物
Jingqing Ma,Jingli Lu,Yanjun Lin et al.
Jingqing Ma et al.
All-trans retinoic acid (ATRA), a bioactive metabolite of vitamin A, is vital for cell development and gene transcription. Coronary artery calcium (CAC) is a risk factor for cardiovascular events but lacks predictive biomarkers and effectiv...
G Breveglieri,M T Altieri,M T Rodia et al.
G Breveglieri et al.
This manuscript is a comprehensive review focused on the role of microRNAs (miRs)-short RNA molecules-in Limb Girdle Muscular Dystrophy (LGMD). LGMD encompasses various and heterogeneous rare genetic neuromuscular diseases, characterized by...
LGMN as a Functionally Significant Prognostic and Immunoregulatory Biomarker in Glioma [0.03%]
LGMN作为胶质瘤中有功能显著的预后和免疫调节生物标志物
Chenyi Nie,Hongsheng Liang,Jiaxin Zhou et al.
Chenyi Nie et al.
Studies have shown that Legumain (LGMN) is a potential protease for immunosuppression in glioblastoma multiforme (GBM). Moreover, the elevated expression of LGMN in different types of cancers is linked to an unfavorable prognosis. However, ...