Bioinformatics-Based Exploration of LMO4-Regulated Hippo Pathway to Reverse Adriamycin Resistance in Breast Cancer [0.03%]
基于生物信息学的LMO4调控Hippo通路逆转乳腺癌阿霉素耐药性研究
Yue Wu,Jiahui Gao,Zejie Su et al.
Yue Wu et al.
The development of acquired drug resistance in breast cancer (BC) significantly compromises treatment efficacy and patient survival, yet the underlying molecular mechanisms remain completely understood. In this study, we investigated the ro...
CircZNF418 Prevents Intervertebral Disc Degeneration by Targeting the HuR/SIRT6 Axis to Protect Against Oxidative Stress-Induced Ferroptosis and Senescence [0.03%]
环状RNA CircZNF418 通过靶向调控 HuR/SIRT6 轴抵抗氧化应激诱导的铁死亡和衰老从而防止椎间盘退变
Ke Wei,Daming Feng,Dongdong Fan et al.
Ke Wei et al.
Intervertebral disc degeneration (IVDD) is a common degenerative disorder affecting the spine. Ferroptosis and cellular senescence are key pathological features driving IVDD progression, but the mechanisms involved in their regulation remai...
Cannabidiol Suppresses EMT in Pancreatic Cancer via Inhibition of MALAT1 lncRNA and PI3K/Akt/mTOR Signaling Pathway [0.03%]
大麻二酚通过抑制MALAT1长链非编码RNA和PI3K/Akt/mTOR信号通路抑制胰腺癌的上皮间质转化
Na Young Kim,Young Yun Jung,Jae-Young Um et al.
Na Young Kim et al.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive metastasis and poor response to chemotherapy, largely driven by epithelial-mesenchymal transition (EMT) and chemokine signaling. Cannabidiol (CBD), a non-psychoactive ph...
RING Finger Protein 4 (RNF4) Reduces Nonalcoholic Fatty Liver Disease Accumulation by Promoting the SUMOylation of HIF-2α and Regulating the PPARα Signaling Pathway [0.03%]
RING指蛋白4通过促进HIF-2α的SUMO化和调节PPARα信号通路减少非酒精性脂肪肝病的积累
Li Yang,Qing Ni,Yan He et al.
Li Yang et al.
RING finger protein 4 (RNF4) acts as a SUMO-targeted ubiquitin ligase, principally regulating protein stability and playing a crucial role in liver injury, inflammatory, and cholestatic diseases. In spite of this, it is unclear how it contr...
The Synergic Inhibition of Wilforlide A With Cisplatin in Lung Cancer Is Mediated Through Caspase-3 and NFκB Signaling [0.03%]
萎-forllide A与顺铂在肺癌中的协同抑制作用通过caspase-3和NFκB信号通路介导
Zhonglu Peng,Xiang Xiao,Xinyi Lu et al.
Zhonglu Peng et al.
Lung cancer is a malignant disease in the respiratory system and accounts for hundreds of thousands of deaths each year. Cisplatin is the first-line drug in the clinic for lung cancer. However, drug resistance and side effects are becoming ...
CircROBO2 Orchestrates Osimertinib Resistance Through miR-625-5p/PDGFB-Mediated MAPK Activation in Non-Small Cell Lung Cancer [0.03%]
Circular RNA CircROBO2通过miR-625-5p/PDGFB介导的MAPK活化调控非小细胞肺癌中奥希替尼耐药性
Miao He,Jiang-Ying Cai,Ying-Ying Wang et al.
Miao He et al.
The emergence of acquired resistance to osimertinib represents a formidable therapeutic challenge in the management of non-small cell lung cancer (NSCLC). While circular RNAs (circRNAs) have been increasingly recognized as crucial modulator...
The IUBMB Focused Meeting on Aminoacyl-tRNA Synthetases 2023 [0.03%]
2023年国际酶与代谢生物化学学会（IUBMB）氨酰-tRNA合成酶专题会议
Patrick O&#x;Donoghue,Ilka U Heinemann
Patrick O&#x;Donoghue
By ligating amino acids to their cognate transfer RNAs (tRNAs), the aminoacyl-tRNA synthetases (AARSs) establish the genetic code in all living cells. This special issue of IUBMB Life is dedicated to the IUBMB Focused Meeting on AARSs in 20...
Editorial
IUBMB life. 2025 Jul;77(7):e70041. DOI:10.1002/iub.70041 2025
MYC-Mediated Osseous Regeneration via BMSCs/PRP/β-TCP/PCL Bioprinted Constructs: Rapid Defect Rehabilitation and Preliminary Clinical Efficacy Evaluation [0.03%]
MYC介导的骨再生：基于BMSCs/PRP/β-TCP/PCL生物打印构建体的快速缺陷修复及初步临床疗效评估研究
Dinghao Luo,Zhaoyang Ran,Junxiang Wu et al.
Dinghao Luo et al.
Bone defects present significant clinical challenges due to their morphological heterogeneity and structural complexity, necessitating regenerative strategies that integrate structural adaptability, biomechanical stability, and osteogenic p...
Deacetylase Inhibitor Trichostatin A Promotes the Proliferation of Epithelial Cells and Suppresses Glycolytic Activity of Fibroblasts in the Kidney [0.03%]
去乙酰化酶抑制剂曲古抑菌素A促进肾上皮细胞增殖并抑制成纤维细胞糖酵解活性
Marina I Buyan,Irina B Pevzner,Andrey I Buyan et al.
Marina I Buyan et al.
Undesirable tissue fibroblast activation after injury is still an unresolved problem for many organs, including the kidney. Kidney fibroblasts and tubular epithelial cells demonstrate significant differences in gene expression profiles, inc...
Establishment of Initiated Cell Line Derived From NIH3T3 Fibroblasts [0.03%]
由NIH3T3成纤维细胞诱导而来的细胞系的建立
Myeong-Han Ro,Taehyun Park,SungHee Hwang et al.
Myeong-Han Ro et al.
Autophagy plays contrasting roles depending on the stage of cellular transformation. However, although advanced tumor cell models are abundant, cell lines at the initiation stage of transformation are very limited. Therefore, the developmen...