Capturing the Variations in Mutant p53-Driven Regulatory Networks in Breast Cancer Subtypes, Its Clinical Relevance and a Novel Association With Androgen Receptor and EMT [0.03%]
捕获乳腺癌亚型中突变型p53驱动的调节网络的差异、其临床相关性及其与雄激素受体和上皮间质转化的新关联
Aastha Singh,Rahul Gupta,Ritu Kulshreshtha
Aastha Singh
The tumour suppressor TP53 is frequently mutated in breast cancer and drives poor outcomes. The impact of mutant p53 (mutp53) on subtype-specific gene and non-coding RNA networks, and their clinical significance, remains largely underexplor...
Multi-Omics Analysis Reveals That the MAZ/HDGF Regulatory Axis Drives High-Grade Serous Ovarian Cancer Progression by Modulating Glycolysis and M2 Macrophage Polarization [0.03%]
多组学分析揭示MAZ/HDGF调节轴通过调控糖酵解和M2型巨噬细胞极化驱动高级别浆液性卵巢癌进展
Ji Liu,Yong-Hong Luo,Su Wan et al.
Ji Liu et al.
Super-enhancers (SEs) are large clusters of enhancers that drive high-level expression of genes critical for normal development and tumorigenesis. However, their precise roles in high-grade serous ovarian carcinoma (HGSOC) remain unclear. T...
Effects of Methylglyoxal on Intestinal Cells: Insights on Epigenetic Regulatory Enzymes [0.03%]
甲基甘油醛对肠细胞的影响：表观遗传调控酶的新见解
Camilla Morresi,Giulia Feliziani,Luisa Bellachioma et al.
Camilla Morresi et al.
Methylglyoxal (MGO) is endogenously produced under physiological conditions as a by-product of glycolysis and by autooxidation of glucose and lipid peroxidation. The digestive system can also take up MGO from exogenous sources, especially f...
A Macrophage-Derived 7-Gene Signature Predicts Prognosis and Therapeutic Response in Hepatocellular Carcinoma [0.03%]
肝细胞癌中一种巨噬细胞来源的7基因标志物可预测预后和治疗反应
Xiaomin Li,Zhilong Li,Jinfang Zhai et al.
Xiaomin Li et al.
This study aimed to identify a novel prognostic signature derived from an EGFR Tyrosine kinase inhibitors (TKI-resistant) macrophage subpopulation and to evaluate its clinical and therapeutic relevance in HCC. We utilized single-cell RNA se...
Oncogenic Role of PTPN14 in Pancreatic Cancer Through β-Catenin/NF-κB Pathway Activation [0.03%]
PTPN14通过β-catenin/NF-κB途径激活在胰腺癌中的致癌作用
Danni Luo,Xiaopan Luo,Shaojie Qian et al.
Danni Luo et al.
Pancreatic cancer (PC) is one of the deadliest malignancies due to early metastasis, therapy resistance, and a highly immunosuppressive microenvironment. Although oncogenic mutations such as KRAS and TP53 are well characterized, the role of...
Silent Guardians Gone Rogue: The Role of PIWI and piRNA in Malignant Transformation [0.03%]
由PIWI和piRNA诱导的恶性转化：寂静的守护者变身叛逆者？
Anthony Lalruatfela,Priyajit Biswal,Subham Kumar Behera et al.
Anthony Lalruatfela et al.
Malignant transformation is not merely the consequence of stochastic genetic mutations but rather a convergence of complex interplay between genetic, epigenetic, and environmental factors that collectively reprogram normal cells into cancer...
G-Patch Domain-Containing Protein 2, Transcriptionally Activated by YY1, Facilitates the Progression of Hepatocellular Carcinoma by Boosting SNAI2 Expression [0.03%]
转录因子YY1通过激活G-Patch域含蛋白2促进SNAI2表达从而推动肝癌进展
Beibei Bie,Hong Bai,Yingnan Li et al.
Beibei Bie et al.
G-patch domain-containing protein 2 (GPATCH2), a member of the G-patch domain-containing family, has been implicated in tumor cell growth, but the link between GPATCH2 and hepatocellular carcinoma (HCC) remains uncertain. In the current stu...
MTFR1 Promotes Proliferation and Metastasis of Triple-Negative Breast Cancer by Regulating Mitochondrial Metabolism [0.03%]
MTFR1通过调节线粒体代谢促进三阴性乳腺癌的增殖和转移
Zhengzhi Zhu,Jing Wang,Jianjun Liu et al.
Zhengzhi Zhu et al.
Mitochondria, as the center of cellular energy metabolism, play multiple key roles in the progression of triple-negative breast cancer (TNBC). Mitochondrial fission regulator 1 (MTFR1) is a mitochondrial regulatory factor that plays a part ...
MIA3 in Coronary Artery Disease (CAD): An In-Depth Review of Its Role in Vascular Smooth Muscle Cell (VSMC) Homeostasis, Pathogenesis, and Its Therapeutic Potential [0.03%]
MIA3在冠心病（CAD）中的作用：其在血管平滑肌细胞稳态、发病机制及治疗潜力的深入综述
Yousuf Tahir Ali,Aarthi Ravindran,Luis Eichelmann et al.
Yousuf Tahir Ali et al.
A significant portion of fatalities from coronary artery disease (CAD) has been attributed to be primarily triggered by atherosclerosis. The melanoma inhibitory activity protein-3 (MIA3) gene has been found to be a key regulator for plaque ...
Next-Generation Nanomaterials in Biology: From Tissue Regeneration to Targeted Cancer Therapy [0.03%]
下一代纳米材料在生物学中的应用：从组织再生至靶向癌症治疗
Debyashreeta Barik,V Badireenath Konkimalla
Debyashreeta Barik
The rapid advancement of nanotechnology has ushered in a new era of biomedical innovation, where nanomaterials serve as powerful tools at the interface of tissue regeneration and targeted cancer therapy. This review explores the dual roles ...