Tissue Factor Driven Coagulation and Inflammation in Lung Injury: Insights From In Vitro and In Vivo Models [0.03%]
组织因子驱动的肺损伤凝血和炎症：来自体外和体内模型的启示
Aleena Varughese,Akarsha Balnadupete,Fathimath Muneesa Moideen et al.
Aleena Varughese et al.
Lung injury and fibrosis involve a complex interplay between inflammation and coagulation, with tissue factor (TF/CF-III/Thromboplastin/CD142) acting as a crucial mediator. Despite its known role in initiating the extrinsic coagulation casc...
17-Oxo-DHA Potentiates Macrophage Efferocytosis via Nrf2/HO-1-Mediated Biosynthesis of Specialized Pro-Resolving Mediators [0.03%]
17-氧代-docosahexaenoic酸通过Nrf2/血红素氧合酶-1介导的特殊性促解决介质生物合成促进巨噬细胞摄取 apoptotic 细胞
Ibrahim Isot,Doga Demir Yangi,Tugce Demirel-Yalciner et al.
Ibrahim Isot et al.
Phagocytic engulfment of apoptotic cells, particularly neutrophils by macrophages, known as efferocytosis, is crucial in preventing secondary necrosis and promoting tissue repair. 17-Oxo-DHA, an electrophilic metabolite of docosahexaenoic a...
DYRK1A Overexpression Drives Muscle Wasting by Impeding Myogenesis via a USP7-Axin1-β-Catenin Regulatory Axis in Mice [0.03%]
DYRK1A过表达通过USP7-Axin1-β-catenin调节轴干扰肌细胞生成驱动肌肉萎缩研究小鼠模型中的相关机制
Mei Lu,Xiaohui Li,Lin Ma et al.
Mei Lu et al.
Muscle wasting, characterized by loss of muscle mass and strength, severely impacts patient quality of life and is associated with numerous chronic diseases and aging. The molecular mechanisms are complex, involving protein synthesis/degrad...
Pan-Cancer Analysis Identifies DIP2B as a Potential Biomarker That Inhibits Kidney Renal Clear Cell Carcinoma Progression [0.03%]
泛癌症分析鉴定出DIP2B是可能抑制肾透明细胞癌发展的生物标志物
Yang Chen,Yao Guo,Ankang Hu et al.
Yang Chen et al.
Disco interacting protein 2 homolog B (DIP2B) is a protein-coding gene implicated in various biological processes, including embryonic development, cell cycle regulation, DNA repair, and transcriptional regulation. While its precise role in...
Unveiling Gamma-Interferon-Inducible Lysosomal Thiol Reductase (IFI30) as a Regulator of Macrophage Polarization and Prognostic Biomarker by Multi-Transcriptome Analysis in Cervical Cancer [0.03%]
多转录组分析揭示γ干扰素诱导的溶酶体硫醇还原酶（IFI30）是宫颈癌巨噬细胞极化调控因子和预后生物标志物
Wei Wang,Yuhua Deng,Yinglin Feng et al.
Wei Wang et al.
Cervical cancer remains a significant challenge to global health, necessitating the development of reliable clinical prognostic models to predict patient survival outcomes with accuracy. This study aims to develop an mRNA signature model ba...
PLEKHF1 Induces Mitochondrial Dysfunction to Inhibit Osteosarcoma Growth and Metastasis [0.03%]
PLEKHF1通过诱导线粒体功能障碍抑制成骨肉瘤生长和转移
Jun Wan,Xinyan Cai,Zhan Liao et al.
Jun Wan et al.
Osteosarcoma (OS) is an uncommon malignancy with stagnant survival rates over the past four decades and early-stage metastasis, predominantly affecting children and adolescents. This study identified significant metabolic differences betwee...
Progress in Nanocarriers-Based Approaches for the Delivery of Tyrosine Kinase Inhibitors in Bone Cancer: Trends and Prospects [0.03%]
基于纳米载体的酪氨酸激酶抑制剂递送在骨癌治疗中的进展：趋势和前景
Dexin Xu,Wenbin Zhang,Yinping Pan et al.
Dexin Xu et al.
Bone cancer remains a life-threatening malignancy predominantly affecting pediatric and adolescent populations, with tyrosine kinase inhibitors (TKIs) emerging as promising therapeutic agents; however, their clinical utility is limited by p...
RETRACTION: Blockade of High Mobility Group Box 1 Involved in the Protective of Curcumin on Myocardial Injury in Diabetes In Vivo and In Vitro [0.03%]
撤稿：体内外姜黄素通过阻断高迁移率族盒蛋白1保护糖尿病心肌损伤研究
X. Yan, P. Xu, L. Zhou, J. Lu, H. Tang, Y. Zheng and H. Cao, "Blockade of High Mobility Group Box 1 Involved in the Protective of Curcumin on Myocardial Injury in Diabetes In Vivo and In Vitro," IUBMB Life 72, no. 5 (2020): 931-941, https:/...
ZEB1 Contributes to Drug Resistance Through Canonical Wnt Signaling in Lung Cancer [0.03%]
ZEB1通过经典Wnt信号转导途径介导肺癌耐药性
Hubo Shi,Min Wang,Qianqian Zhao et al.
Hubo Shi et al.
Lung cancer is a severe malignant disease and causes plenty of deaths each year. The survival and prognosis are disappointing for patients with recurrence or metastasis. This is partially due to the lack of mechanisms underlying lung cancer...
Integrated Analysis of Single-Cell and Bulk RNA Sequencing Data Reveals Cellular Senescence-Related Signatures Predicting New Potential Therapeutic Drugs in Hepatic Ischemia-Reperfusion Injury [0.03%]
单细胞和批量RNA测序数据的综合分析揭示了与肝缺血再灌注损伤相关衰老相关的特征，预测新的潜在治疗药物
Junlin Chen,Huaming Huang,Zhi Lu et al.
Junlin Chen et al.
Three human bulk RNA sequencing (RNA-seq) datasets from the GEO database, comprising liver tissues from 76 patients with hepatic ischemia-reperfusion injury (IRI) and 80 controls, were analyzed to identify differentially expressed genes rel...