Low SFXN1 Expression Predicts Poor Clinical Outcomes and Promotes Tumor Aggressiveness in Colon Adenocarcinoma [0.03%]
低SFXN1表达预测结肠腺癌不良临床结局并促进肿瘤侵袭性
Jie Zhu,Yuchen Huang,Xiaoqin Wu et al.
Jie Zhu et al.
Sideroflexin 1 (SFXN1), predominantly localized in the inner mitochondrial membrane, exhibits differential expression across various tumor types. However, its specific role in colon adenocarcinoma (COAD) remains unclear. This study aimed to...
Single-Cell Dissection of Malignant Cell Heterogeneity Reveals Functional Programs and Clinically Relevant Subtypes in Head and Neck Squamous Cell Carcinoma [0.03%]
单细胞解析恶性肿瘤异质性揭示头颈鳞癌功能亚型及临床分型
Ahmed Osman Mohamed,Yin He,Xiaosheng Wang
Ahmed Osman Mohamed
Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with poor prognosis and limited predictive biomarkers for therapy response. Characterizing malignant cell heterogeneity may improve prognostic and therapeuti...
Integration of Single-Cell and Spatial Transcriptomics With Experimental Validation Uncovers Macrophage Diversity and Spatial Landscape in Carotid Atherosclerosis [0.03%]
单细胞和空间转录组学的整合及实验验证揭示了颈动脉粥样硬化中巨噬细胞的多样性和空间图谱
Rongxing Qin,Caiqi Li,Hongyu Xu et al.
Rongxing Qin et al.
The core pathogenesis of carotid atherosclerosis (CAS) lies in the rupture of vulnerable plaques, with macrophages (MC) playing a critical role in plaque progression and destabilization. However, the functional characteristics of MC subpopu...
HIF Signalling Modulates p53/miR-145-5p Axis in Hypoxia-Driven Tumorigenesis of HepG2 Tumourspheres [0.03%]
缺氧驱动的HIF信号调节肝癌细胞球体发生过程中的p53/miR-145-5p轴
Sakunie Sawai,Pooi-Fong Wong,Thamil Selvee Ramasamy
Sakunie Sawai
Hypoxia is associated with increased tumour aggressiveness and relapses in hepatocellular carcinoma (HCC) through HIF signalling. Tumour suppressor p53, its deacetylase SIRT1 and liver-specific miRNAs are deregulated in hypoxia, further dri...
Hypoxia-Inducible Factors as Guardians of Cancer Stem Cell Fate: Implications for Novel Therapies [0.03%]
缺氧诱导因子在癌症干细胞命运中的作用及其对新型疗法的意义
Qamar Abuhassan,Hamzeh J Al-Ameer,Hani Moslem Ahmed et al.
Qamar Abuhassan et al.
Cancer stem cells (CSCs) represent a dynamic, therapy-refractory subpopulation that fuels tumor initiation, metastasis, and relapse through remarkable self-renewal capacity and phenotypic plasticity. Extensive evidence has established that ...
Nanocurcumin in Oral Disease Therapy: A Review of Innovations and Future Prospects [0.03%]
纳米姜黄素在口腔疾病治疗中的研究进展与未来展望
Quanbing Wang,Ke Jiang,Xiaofei Lan et al.
Quanbing Wang et al.
Curcumin exhibits strong anti-inflammatory, antioxidant, and anticancer activities. However, its clinical use is limited due to poor solubility, low gastrointestinal absorption, and rapid systemic metabolism. Nanocurcumin offers enhanced so...
Self-Assembled Nanovaccines: A Promising Strategy for Overcoming Influenza Variability and Advancing Universal Vaccine Development [0.03%]
自我组装纳米疫苗：克服流感变异和推进通用型疫苗发展的前景策略
Chou-Yi Hsu,Ihab M Abdelrahim,Ahmed Hjazi et al.
Chou-Yi Hsu et al.
Influenza viruses present an ongoing global health risk because they are always changing, which in turn results in the ineffectiveness of current strain-specific vaccines and leaves the world vulnerable to potential pandemics. The need for ...
Lipo-Glc-1,6-P2: A Bioprecursor Prodrug for Phosphomannomutase-2 Congenital Disorder of Glycosylation [0.03%]
Lipo-Glc-1,6-P2：磷甘露糖 mutase-2糖基化障碍的生物前体药物
Federica Sodano,Maria Monticelli,Bruno Hay Mele et al.
Federica Sodano et al.
Phosphomannomutase-2 (PMM2) deficiency leads to the prominent Congenital Disorder of Glycosylation (CDG), a rare disease currently lacking effective treatment options. The complete absence of PMM2 activity is incompatible with life, and all...
Deciphering the Angiogenic Switch: The Role of miRNAs in Breast Cancer [0.03%]
解读生理性新生血管形成与恶化性病理性新生血管形成的开关：微小核糖核酸在乳腺癌中的作用
Heba Ibrahim Abd El-Moaty,Ahmed S Doghish,Shaza H Aly et al.
Heba Ibrahim Abd El-Moaty et al.
Angiogenesis, which is the formation of new blood vessels from existing vasculature, exhibits a pivotal role in breast cancer progression and promotes metastasis. This complex biological process is influenced by the dynamic balance of pro- ...
CYP17A1 Locus: Regulatory Mechanisms and Clinical Associations With Cardiovascular Disease and Metabolic Syndrome [0.03%]
CYP17A1 位点：调控机制及其与心血管疾病和代谢综合征的临床关联
Yasmine Chakkor,Redouane Aherrahrou
Yasmine Chakkor
The CYP17A1 gene encodes the P450 17α-hydroxylase/17,20-lyase protein, a key enzyme in steroidogenesis. In the past, it was associated with disorders such as congenital adrenal hyperplasia, disorders of sex development, and castration resi...