Nuclear Aggregates of Polyamines-DNA Complexes Imply a Genomic Electronic Circuit [0.03%]
多胺-DNA复合物的核聚集体暗示了基因组电子电路
Giuseppe Iacomino,Gianluca Picariello,Luciano D&#x;Agostino
Giuseppe Iacomino
This review introduces a novel conceptual framework, which suggests that key DNA functions, including rapid gene activation, conformational changes, and chromosomal structuring, could be regulated by an electronic-like circuit. The winding ...
Gastric Cancer Cell-Derived Exosomes Induce Macrophage M2 Polarization by Delivering circSMARCC1 to Promote Gastric Cancer Progression [0.03%]
胃癌细胞来源的外泌体通过递送circSMARCC1诱导M2型巨噬细胞极化促进胃癌进展
Cao Zhang,Jingjing Ye,Qingsong Guan et al.
Cao Zhang et al.
Exosomes, the cargo of circRNA, are crucial in cancer cell-tumor microenvironment communication. circSMARCC1 exerts a pro-tumor effect. However, this role has not been previously reported in gastric cancer (STAD). This study explores the ro...
All-Trans Retinoic Acid as a Predictor and Therapeutic Agent for Vascular Calcification [0.03%]
全反式维甲酸可作为血管钙化的预测和治疗标志物
Jingqing Ma,Jingli Lu,Yanjun Lin et al.
Jingqing Ma et al.
All-trans retinoic acid (ATRA), a bioactive metabolite of vitamin A, is vital for cell development and gene transcription. Coronary artery calcium (CAC) is a risk factor for cardiovascular events but lacks predictive biomarkers and effectiv...
G Breveglieri,M T Altieri,M T Rodia et al.
G Breveglieri et al.
This manuscript is a comprehensive review focused on the role of microRNAs (miRs)-short RNA molecules-in Limb Girdle Muscular Dystrophy (LGMD). LGMD encompasses various and heterogeneous rare genetic neuromuscular diseases, characterized by...
LGMN as a Functionally Significant Prognostic and Immunoregulatory Biomarker in Glioma [0.03%]
LGMN作为胶质瘤中有功能显著的预后和免疫调节生物标志物
Chenyi Nie,Hongsheng Liang,Jiaxin Zhou et al.
Chenyi Nie et al.
Studies have shown that Legumain (LGMN) is a potential protease for immunosuppression in glioblastoma multiforme (GBM). Moreover, the elevated expression of LGMN in different types of cancers is linked to an unfavorable prognosis. However, ...
Troyee Das,Byapti Ghosh,Arijita Sarkar et al.
Troyee Das et al.
PIWI-interacting RNAs (piRNAs) have emerged as key gene regulators in diverse biological processes. Earlier believed to be germline-specific, these endogenous small non-coding RNAs (~26-32 nucleotides) have now been identified to play an ac...
SNORA33 Promotes Clear Cell Renal Cell Carcinoma Development and Resistance to Sunitinib Through Triggering the JAK/STAT Pathway [0.03%]
SNORA33通过激活JAK/STAT途径促进透明细胞肾细胞癌的发生和发展及苏尼替尼耐药性
Jiajia Sun,Shuo Zhao,Xiaochen Ren et al.
Jiajia Sun et al.
Accumulating evidence has confirmed that snoRNAs exert a role in a variety of cancers; however, the role of SNORA33 in clear cell renal cell carcinoma (ccRCC) remains unclear. This study was aimed at elucidating the role and mechanism of SN...
Exploring Macrophage Contribution to Vascular Calcification in Atherosclerosis [0.03%]
动脉粥样硬化血管钙化形成中巨噬细胞的作用机制探讨
Siarhei A Dabravolski,Mikhail A Popov,Olga N Maltseva et al.
Siarhei A Dabravolski et al.
Vascular calcification (VC) is a significant pathological feature of atherosclerosis, contributing to cardiovascular morbidity and mortality, particularly in populations with diabetes and chronic kidney disease (CKD). This review examines t...
Analysis of miRNA Expression Profiles in High Cholesterol Diet-Induced MASH Progression: Potential Effect of α-Tocopherol [0.03%]
高胆固醇饮食诱导的MASH进展中miRNA表达特征分析及α-生育酚的潜在干预效应
Tugce Demirel-Yalciner,Bengu Cetinkaya,Kazim Yalcin Arga et al.
Tugce Demirel-Yalciner et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD), defined by fat accumulation in more than 5% of hepatocytes, is a common metabolic syndrome worldwide. However, 30%-40% of MAFLD cases progress to metabolic dysfunction-associated...