Deletion of the polyketide synthase-encoding gene pks1 prevents melanization in the extremophilic fungus Cryomyces antarcticus [0.03%]
极端嗜极真菌Cryptosporiopsis.antarctica中PKS1基因的缺失阻止了黑色素的形成
Ilaria Catanzaro,Ruben Gerrits,Ines Feldmann et al.
Ilaria Catanzaro et al.
Cryomyces antarcticus, a melanized cryptoendolithic fungus endemic to Antarctica, can tolerate environmental conditions as severe as those in space. Particularly, its ability to withstand ionizing radiation has been attributed to the presen...
Utilizing adeno-associated virus as a vector in treating genetic disorders or human cancers [0.03%]
利用腺相关病毒作为载体治疗遗传病或人类癌症
Fu-Hsuan Shih,Hsiung-Hao Chang,Yi-Ching Wang
Fu-Hsuan Shih
Clinical data from over two decades, involving more than 3000 treated patients, demonstrate that adeno-associated virus (AAV) gene therapy is a safe, effective, and well-tolerated therapeutic method. Clinical trials using AAV-mediated gene ...
Review
IUBMB life. 2024 Jul 6. DOI:10.1002/iub.2896 2024
Pore-forming aegerolysin and MACPF proteins in extremotolerant or extremophilic fungi [0.03%]
耐极端环境真菌中的成孔蛋白aegerolysin和MACPF蛋白
Nada Kraševec
Nada Kraševec
Aegerolysin proteins are involved in various interactions by recognising a molecular receptor in the target organism. The formation of pores in combination with larger, non-aegerolysin-like protein partners (such as membrane attack complex/...
Comparative proteomics uncovers low asparagine content in Plasmodium tRip-KO proteins [0.03%]
比较蛋白质组学发现裂殖体减缓 knockout 疟原虫蛋白天冬酰胺含量较低
Martina Pitolli,Marta Cela,Delphine Kapps et al.
Martina Pitolli et al.
tRNAs are not only essential for decoding the genetic code, but their abundance also has a strong impact on the rate of protein production, folding, and on the stability of the translated messenger RNAs. Plasmodium expresses a unique surfac...
Apurinic/apyrimidinic endonuclease 1 has major impact in prevention of suicidal covalent DNA-protein crosslink with apurinic/apyrimidinic site in cellular extracts [0.03%]
无嘌呤/嘧啶内切酶1可防止细胞提取物中的自杀性共价DNA-蛋白质交联在无嘌呤/嘧啶位点形成
Natalia A Lebedeva,Nadezhda S Dyrkheeva,Nadejda I Rechkunova et al.
Natalia A Lebedeva et al.
DNA-protein crosslinks (DPC) are common DNA lesions induced by various external and endogenous agents. One of the sources of DPC is the apurinic/apyrimidinic site (AP site) and proteins interacting with it. Some proteins possessing AP lyase...
Oral administration of herbal oligonucleotide drug JGL-sRNA-h7 ameliorates hyperglycemia in db/db mice and beagle dogs [0.03%]
口服中草药寡核苷酸药物JGL-sRNA-h7可改善小鼠和猎肠梗阻犬的高血糖症状
Kegong Tang,Xiaona Wang,Zhenyu Jiang et al.
Kegong Tang et al.
Type 2 diabetes mellitus is a prevalent metabolic disease, posing a considerable threat to public health. Oligonucleotide drugs have proven to be a promising field of therapy for the diseases. In this study, we reported that a herbal small ...
Potential COVID-19 remedies from repurposed drugs and herbal small RNAs [0.03%]
来源于药物再利用和草药小RNA的潜在冠状病毒疗法
Yang Yang,Fengming Huang,Xiangyu Qiao et al.
Yang Yang et al.
To date, SARS-CoV-2 has caused millions of deaths, but the choice of treatment is limited. We previously established a platform for identifying Food and Drug Administration (FDA)-approved repurposed drugs for avian influenza A virus infecti...
Parecoxib inhibits tumorigenesis and angiogenesis in hepatocellular carcinoma through ERK-VEGF/MMPs signaling pathway [0.03%]
选择性环氧合酶-2抑制剂帕瑞昔布通过ERK-VEGF/MMP信号途径抑制肝癌的生长和新生血管形成
Li Tian,YuQi Huang,Yan Liu et al.
Li Tian et al.
Parecoxib, a well-recognized nonsteroidal anti-inflammatory drug, has been reported to possess anticancer properties in various tumor types. In this work, we aimed to investigate the potential anticancer effects of parecoxib on hepatocellul...
Hederagenol improves multiple sclerosis by modulating Th17 cell differentiation [0.03%]
鹤虱醇通过调节Th17细胞分化治疗多发性硬化病
Dongsheng Guan,Yingxia Li,Xu Zhao et al.
Dongsheng Guan et al.
Multiple sclerosis (MS) is a common autoimmune illness that is difficult to treat. The upregulation of Th17 cells is critical in the pathological process of MS. Hederagenol (Hed) has been shown to lower IL-17 levels, although its role in MS...
Neuroprotection and mechanisms of ginsenosides in nervous system diseases: Progress and perspectives [0.03%]
人参皂苷的神经保护作用及其在神经系统疾病中的机制研究：进展与展望
Li Zhou,Feilong Tan,Xue Zhang et al.
Li Zhou et al.
Ginsenosides are the primary component discernible from ginseng, including Rb1, Rb2, Rd, Rg1, Rg2, and compound K, and so forth. They have been shown to have multiple pharmacological activities. In recent years, more and more studies have b...
Review
IUBMB life. 2024 Jun 1. DOI:10.1002/iub.2862 2024