Extracellular adenosine oppositely regulates the purinome machinery in glioblastoma and mesenchymal stem cells [0.03%]
细胞外腺苷通过相反调节胶质母细胞瘤和间充质干细胞中的嘌呤能机制发挥作用
Deborah Pietrobono,Lara Russo,Maria Sofia Bertilacchi et al.
Deborah Pietrobono et al.
Glioblastoma (GB) is a lethal brain tumor that rapidly adapts to the dynamic changes of the tumor microenvironment (TME). Mesenchymal stem/stromal cells (MSCs) are one of the stromal components of the TME playing multiple roles in tumor pro...
lncRNAs: New players of cancer drug resistance via targeting ABC transporters [0.03%]
长链非编码RNA通过作用于ABC转运蛋白参与肿瘤耐药性
Mohammad Ebrahimnezhad,Sanaz Hassanzadeh Asl,Maede Rezaie et al.
Mohammad Ebrahimnezhad et al.
Cancer drug resistance poses a significant obstacle to successful chemotherapy, primarily driven by the activity of ATP-binding cassette (ABC) transporters, which actively efflux chemotherapeutic agents from cancer cells, reducing their int...
HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β-catenin pathway in 6-OHDA-induced Parkinson's disease model [0.03%]
人脐带源间充质干细胞外泌体通过上调SATB1激活Wnt/β-catenin信号通路缓解6-羟基多巴诱导的帕金森病小鼠模型作用研究
Ying He,Ruicheng Li,Yuxi Yu et al.
Ying He et al.
Parkinson's disease (PD) is a degenerative disorder of the nervous system characterized by the loss of dopaminergic neurons and damage of neurons in the substantia nigra (SN) and striatum, resulting in impaired motor functions. This study a...
Analyzing the role of ferroptosis in ribosome-related bone marrow failure disorders: From pathophysiology to potential pharmacological exploitation [0.03%]
铁死亡在核糖体相关骨髓衰竭性疾病中的作用分析：从病理生理到潜在的药理学应用
Aliki Papadimitriou-Tsantarliotou,Chrysostomos Avgeros,Maria Konstantinidou et al.
Aliki Papadimitriou-Tsantarliotou et al.
Within the last decade, the scientific community has witnessed the importance of ferroptosis as a novel cascade of molecular events leading to cellular decisions of death distinct from apoptosis and other known forms of cell death. Notably,...
COX-2/PTGS2-targeted herbal-derived oligonucleotide drug HQi-sRNA-2 was effective in spontaneous mouse lung cancer model [0.03%]
特异性靶向小分子HQi-sRNA-2抑制肺肿瘤自发形成和转移
Yexuan Lin,Na Sun,Dengyuan Liu et al.
Yexuan Lin et al.
In 2020, the number of deaths caused by lung cancer worldwide reached 1,796,144, making it the leading cause of cancer-related deaths. Cyclooxygenase-2/prostaglandin endoperoxide synthase 2 (COX-2/PTGS2) is overexpressed in lung cancer, whi...
Optimization of the chromium (Cr+6) reduction from waterways using chemically and bacterially treated agro-waste [0.03%]
化学和细菌处理农业废弃物优化去除水体中六价铬的研究
Jayeshkumar Ruparelia,Rishit A Soni,Hiren K Patel
Jayeshkumar Ruparelia
Heavy metals, a major source of pollution in the environment, pose a substantial threat due to their non-biodegradability and ability to accumulate in living organisms, causing health problems. Recently, researchers have been searching for ...
Enhancing the activation of T cells through anti-CD3/CD28 magnetic beads by adjusting the antibody ratio [0.03%]
通过调整抗体比例利用抗CD3/CD28磁珠活化T细胞的能力增强研究
Yinuo Chen,Rui Zhao,Qi Fan et al.
Yinuo Chen et al.
The utilization of anti-CD3/CD28 magnetic beads for T cell expansion in vitro has been investigated for adoptive cell transfer therapy. However, the impact of the CD3/CD28 antibody ratio on T cell differentiation and function remains incomp...
Microtubule depolymerization induces ferroptosis in neuroblastoma cells [0.03%]
微管解聚可诱导神经母细胞瘤细胞铁死亡发生
Mayuri Bandekar,Dulal Panda
Mayuri Bandekar
Estramustine (EM), a clinically successful hormone-refractory anti-prostate cancer drug, exhibited potent anti-proliferative activity, depolymerized microtubules, blocked cells at mitosis, and induced cell death in different cancer cells. A...
Bencaosome [16:0 Lyso PA+XLGB28-sRNA] improves osteoporosis by simultaneously promoting osteogenesis and inhibiting osteoclastogenesis in mice [0.03%]
苯钙索[16：0 LysoPA+XLGB28-sRNA]通过在小鼠中同时促进成骨和抑制破骨细胞生成来改善骨质疏松症
Xinyi Du,Shaoting Guo,Xuemeng Mu et al.
Xinyi Du et al.
Osteoporosis (OP) is a systemic metabolic bone disease resulting in reduced bone strength and increased susceptibility to fractures, making it a significant public health and economic problem worldwide. The clinical use of anti-osteoporosis...