Thiouracil and triazole conjugate induces autophagy through the downregulation of Wnt/β-catenin signaling pathway in human breast cancer cells [0.03%]
噻唑黄嘌呤共轭物通过下调Wnt/β-连环蛋白信号通路诱导人乳腺癌细胞的自噬作用
Bada Yoon,Basappa Basappa,Shreeja Basappa et al.
Bada Yoon et al.
Autophagy is vital for maintaining cellular homeostasis by breaking down unnecessary organelles and proteins within cells. Its activity varies abnormally in several diseases, including cancer, making it a potential target for therapeutic st...
AARS Online: A collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases [0.03%]
线性翻译即可，题目中的缩写词AARS需要保留缩写形式： “AARS在线数据库：氨基酸tRNA合成酶的结构、功能及进化”
Jordan Douglas,Haissi Cui,John J Perona et al.
Jordan Douglas et al.
The aminoacyl-tRNA synthetases (aaRS) are a large group of enzymes that implement the genetic code in all known biological systems. They attach amino acids to their cognate tRNAs, moonlight in various translational and non-translational act...
Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function [0.03%]
小胶质细胞与脑glymphatic系统的昼夜节律同步并调节其功能
Ting Yang,Yan Tang,Xinghua Liu et al.
Ting Yang et al.
Microglia, as immune cells in the central nervous system, possess the ability to adapt morphologically and functionally to their environment. Glymphatic system, the principal waste clearance system in the brain, exhibits circadian rhythms. ...
Melatonin effect on breast and ovarian cancers by targeting the PI3K/Akt/mTOR pathway [0.03%]
褪黑素通过靶向PI3K/Akt/mTOR途径影响乳腺癌和卵巢癌的研究进展
Vahid Pourbarkhordar,Sohrab Rahmani,Ali Roohbakhsh et al.
Vahid Pourbarkhordar et al.
Melatonin, the hormone of the pineal gland, possesses a range of physiological functions, and recently, its anticancer effect has become more apparent. A more thorough understanding of molecular alterations in the components of several sign...
Lectins CGL and MTL, representatives of mytilectin family, exhibit different antiproliferative activity in Burkitt's lymphoma cells [0.03%]
代表mytilectin家族的凝集素CGL和MTL在Burkitt淋巴瘤细胞中表现出不同的抗增殖活性
Alexandra S Kuzmich,Alina P Filshtein,Galina N Likhatskaya et al.
Alexandra S Kuzmich et al.
Lectins are carbohydrate-binding proteins, whose biological effects are exerted via binding to glycoconjugates expressed on the surface of cells. Exposure to lectins can lead not only to a change in the structure and properties of cells but...
Neuroprotective effects of resveratrol through modulation of PI3K/Akt/GSK-3β pathway and metalloproteases [0.03%]
通过调节PI3K/Akt/GSK-3β信号通路和金属蛋白酶发挥的白藜芦醇神经保护作用
Lütfiye Ozpak,Bakiye Göker Bağca
Lütfiye Ozpak
To analyze the expressional changes in the PI3K/Akt/GSK-3β pathway and metalloprotease in the cellular Alzheimer's Disease (AD) model with the effect of antioxidant resveratrol. Neuron-like cells were obtained by a two-step method of neuro...
Irisin alleviates the pyroptosis of β cells in T2DM by inhibiting NLRP3 inflammasome through regulating miR-19b-3p/SOCS3/STAT3 axis mediated autophagy [0.03%]
irisin通过调节miR-19b-3p/SOCS3/STAT3轴介导的自噬抑制NLRP3炎性小体以缓解T2DM中β细胞的焦亡作用
Jingjing Yang,Anjun Tan,Tianrong Li et al.
Jingjing Yang et al.
The purpose of this study was to analyze the mechanism by which irisin affects β-cell pyroptosis in type 2 diabetes mellitus (T2DM). The in vivo T2DM model was established by raised with high-fat diet and intraperitoneally injection of str...
Inhibition of transglutaminase 2 inhibits ionizing radiation-induced cellular senescence in skin keratinocytes in vitro [0.03%]
组织移植抗原-3/TGGT2介导的细胞间γ氨基丁酸转移在调节小鼠皮肤免疫稳态中的作用
Juping Chen,Jiang Ma,Dandan Qi et al.
Juping Chen et al.
Senescent cells are typically characterized by a stable proliferation arrested in dividing cells accompanied with a senescence-associated secretory phenotype (SASP). Skin cellular senescence is the primary cause of skin aging, whereas the l...
CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1 [0.03%]
人子宫平滑肌细胞系PHM1中CD38/cADPR介导的钙信号转导
Soner Dogan,Timothy F Walseth,Bilge Guvenc Tuna et al.
Soner Dogan et al.
Cyclic ADP-ribose (cADPR) has emerged as a calcium-regulating second messenger in smooth muscle cells. CD38 protein possesses ADP-ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We have previousl...
The role of the gut microbiome in modulating immunotherapy efficacy in colorectal cancer [0.03%]
肠道菌群在调节结直肠癌免疫治疗疗效中的作用
Siyuan Zuo,Yong Huang,Junwei Zou
Siyuan Zuo
This systematic literature review and meta-analysis provide an overview of the critical role of gut microbiota in modulating the efficacy of immunotherapy for colorectal cancer. Gut microbes influence host immune responses through multiple ...