USP4 expression independently predicts favorable survival in lung adenocarcinoma [0.03%]
USP4表达在肺腺癌患者中独立预后生存期的良好指标
Ming Zhong,Qi Jiang,Ronghui Jin
Ming Zhong
Ubiquitin specific protease 4 (USP4) is a member of the USPs family, which catalyzes the cleavage of ubiquitin from a series of protein substrates, thereby modulating a number of cellular signaling pathways. In this study, we aimed to explo...
The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle [0.03%]
谷胱甘肽循环：超越γ-谷氨酰胺循环的谷胱甘肽代谢
Anand Kumar Bachhawat,Shambhu Yadav
Anand Kumar Bachhawat
Glutathione was discovered in 1888, over 125 years ago. Since then, our understanding of various functions and metabolism of this important molecule has grown over these years. But it is only now, in the last decade, that a somewhat complet...
MicroRNA-21 drives the switch to a synthetic phenotype in human saphenous vein smooth muscle cells [0.03%]
microRNA-21通过促进人的大隐静脉平滑肌细胞向合成表型转化来诱导内膜增生性疾病的发展
Aliah R Alshanwani,Kirsten Riches-Suman,David J O&#x;Regan et al.
Aliah R Alshanwani et al.
Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and ...
L-rhamnose induces browning in 3T3-L1 white adipocytes and activates HIB1B brown adipocytes [0.03%]
D-核糖诱导3T3-L1白色脂肪细胞褐变并激活HIB1B棕色脂肪细胞
Minji Choi,Sulagna Mukherjee,Nam Hyeon Kang et al.
Minji Choi et al.
Induction of the brown adipocyte-like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due to the ability of brown adipocytes to increase energy expenditure. Here, we report that L-rhamnose induced...
Effect of resveratrol on doxorubicin resistance in breast neoplasm cells by modulating PI3K/Akt signaling pathway [0.03%]
茋通过调节PI3K/Akt信号通路影响其对乳腺肿瘤细胞多柔比星耐药性的作用研究
Ju-Min Chen,Jun-Yun Bai,Kun-Xian Yang
Ju-Min Chen
In the study, we probed into the effect of Resveratrol (RES) on Doxorubicin (DOX)-resistant breast neoplasm cell line MCF-7/DOX as well as the mechanism of RES underlying the DOX-resistant breast cancer. CCK-8 assay was utilized to assess t...
Nordihydroguaiaretic acid can suppress progression of experimental autoimmune encephalomyelitis [0.03%]
Nordihydroguaiaretic酸可以抑制实验性自身免疫性脑脊髓炎的发展
Liang Wang,Lin Li,Mo-Yuan Quan et al.
Liang Wang et al.
Multiple sclerosis (MS) is a poorly understood disease mechanistically. MOG35-55 peptide induced experimental autoimmune encephalomyelitis (EAE) is a broadly used model to study MS. Using this model we have earlier shown that the antioxidan...
Discriminating gastric cancer and gastric ulcer using human plasma amino acid metabolic profile [0.03%]
基于人血浆氨基酸代谢谱的胃癌与胃溃疡鉴别诊断研究
Fangyu Jing,Xin Hu,Yunfeng Cao et al.
Fangyu Jing et al.
Patients with gastric ulcer (GU) have a significantly higher risk of developing gastric cancer (GC), especially within 2 years after diagnosis. The main way to improve the prognosis of GC is to predict the tumorigenesis and metastasis in th...
Impact of wedelolactone in the anti-glycation and anti-diabetic activity in experimental diabetic animals [0.03%]
Wedelolactone对实验性糖尿病动物抗糖基化和抗糖尿病活性的影响
Uzma Shahab,Mohammad Faisal,Abdulrahman A Alatar et al.
Uzma Shahab et al.
The glycation reaction is the addition of free carbonyl group of reducing sugar to the free amino groups of proteins, lipoproteins and nucleic acids which results in the formation of an Amadori product which may ultimately lead to the gener...
Caffeic acid phenethyl ester guards against benign prostate hypertrophy in rats: Role of IGF-1R/protein kinase-B (Akt)/β-catenin signaling [0.03%]
咖啡酸苯乙酯通过调节IGF-1R/蛋白激酶-B( Akt)/ β-连环素信号通路预防良性前列腺肥大
Hany A Omar,Mai F Tolba
Hany A Omar
Benign prostate hypertrophy (BPH) is among the most common diseases with a huge impact on the quality of life of elderly men. There is a current need for the development of well-tolerated and effective preventive strategies to improve the c...
Svetlana E Soboleva,Tat&#x;yana A Guschina,Georgy A Nevinsky
Svetlana E Soboleva
It is known that that human serum albumin (HSA) and alpha-lactalbumin (LA) possess DNA-binding sites. Electrophoretically homogeneous HSA and LA containing no canonical enzymes were isolated from human sera and milk. Here we have analyzed f...