Different effects of dexmedetomidine and midazolam on the expression of NR2B and GABAA-α1 following peripheral nerve injury in rats [0.03%]
右美托咪啶和咪达唑仑对坐骨神经损伤大鼠NR2B和GABAA-α1表达的差异效应研究
Jiayu Chen,Hanjun Li,Grewo Lim et al.
Jiayu Chen et al.
Neuropathic pain is a complex, chronic pain condition and the treatment is a major clinical challenge. Recent studies have shown that two FDA approved drugs dexmedetomidine (DEX) and midazolam (MZL), may be useful in treating neuropathic pa...
Hydrolysis by catalytic IgGs of microRNA specific for patients with schizophrenia [0.03%]
精神分裂症患者特异性microRNA的催化型IgG水解作用研究
Evgeny A Ermakov,Svetlana A Ivanova,Valentina N Buneva et al.
Evgeny A Ermakov et al.
Significant importance of autoimmune changes in the pathogenesis of schizophrenia (SCZ) is not established. Here, we present the first evidence that autoantibodies of 100% SCZ patients possess RNase activity: сCMP > poly(C) > poly(A) > yea...
Titli Nargis,Partha Chakrabarti
Titli Nargis
Dipeptidyl peptidase 4 (DPP4), also known as CD26 is a type II transmembrane protein that is released from the cell membrane in a nonclassical secretory mechanism. This exopeptidase selectively degrades varieties of substrates including inc...
Heme oxygenase-1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells [0.03%]
血红素氧化酶-1影响诱导多能干细胞的生成及心脏细胞自发分化
Jacek Stepniewski,Tomasz Pacholczak,Aniela Skrzypczyk et al.
Jacek Stepniewski et al.
Cellular stress can influence efficiency of iPSCs generation and their differentiation. However, the role of intracellular cytoprotective factors in these processes is still not well known. Therefore, we investigated the effect of HO-1 (Hmo...
Regulators of spindle microtubules and their mechanisms: Living together matters [0.03%]
纺锤体微管调控及其机制：共存才有竞争力
R Bhagya Lakshmi,Vishnu M Nair,Tapas K Manna
R Bhagya Lakshmi
Development and survival of all eukaryotic organisms depend on equal partitioning of their chromosomes between the two newly formed daughter cells during mitosis. The mitotic spindle performs the task of physically segregating the chromosom...
Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level [0.03%]
STRAP下调通过降低PTEN水平促进肝癌生长和转移
Qiong Wu,Shijun Yu,Jingde Chen et al.
Qiong Wu et al.
The serine-threonine kinase receptor-associated protein (STRAP) has been implicated in multiple human cancers. However, its expression and function are currently unclear and controversial in different tissue types. In the present study, we ...
MicroRNA-204 deregulation in lung adenocarcinoma controls the biological behaviors of endothelial cells potentially by modulating Janus kinase 2-signal transducer and activator of transcription 3 pathway [0.03%]
微小核糖核酸-204功能异常通过调控janus激酶2-信号转导及转录激活蛋白3通路影响肺腺癌生物学行为
Xiangdong Liu,Xiang Gao,Wentao Zhang et al.
Xiangdong Liu et al.
MicroRNAs (miRNAs) have been implicated in a wide range of biological processes including angiogenesis. MiR-204 was identified as a tumor suppressor in multiple cancer types, including lung adenocarcinoma. However, the function of miR-204 i...
Geetika Sharma,Harsha Raheja,Saumitra Das
Geetika Sharma
Hepatitis C virus (HCV) has infected over 170 million people world-wide. This infection causes severe liver damage that can progress to hepatocellular carcinoma leading to death of the infected patients. Development of a cell culture model ...
Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia [0.03%]
川芎嗪通过Bax/Bcl-2和caspase-3信号通路抑制PC12细胞及血管性痴呆大鼠神经元凋亡
Tengfei Zhao,Yingxue Fu,Hao Sun et al.
Tengfei Zhao et al.
The aim of this study was to examine the comprehensive neuroprotective mechanism of ligustrazine, which is extracted from Ligusticum Chuanxiong Hort., against vascular dementia (VD) in rats and apoptosis in oxygen and glucose deprivation (O...
miR-191/DAB2 axis regulates the tumorigenicity of estrogen receptor-positive breast cancer [0.03%]
miR-191/DAB2轴调节雌激素受体阳性乳腺癌的致癌性
Xinxin Tian,Zhiqian Zhang
Xinxin Tian
Disabled-2 (DAB2) has been shown to be downregulated in a variety of human cancer types including breast tumors. However, the role of DAB2 in estrogen receptor positive (ER+) breast cancer cells has not been reported. In this context, we de...