Victoria Keller,Anjuli Calchera,Jürgen Otte et al.
Victoria Keller et al.
Lichens are mutualistic associations consisting of a primary fungal host, and one to few primary phototrophic symbiont(s), usually a green alga and/or a cyanobacterium. They form complex thallus structures, which provide unique and stable h...
Human disease-causing missense genetic variants are enriched in the evolutionarily ancient domains of the cytosolic aminoacyl-tRNA synthetase proteins [0.03%]
人类致病的错义基因突变在细胞质氨基酰-tRNA合成酶蛋白的进化古Domains富集
Alexandra K Turvey,André R O Cavalcanti
Alexandra K Turvey
All life depends on accurate and efficient protein synthesis. The aminoacyl-tRNA synthetases (aaRSs) are a family of proteins that play an essential role in protein translation, as they catalyze the esterification reaction that charges a tr...
Integrated multi-omics and machine learning reveal a gefitinib resistance signature for prognosis and treatment response in lung adenocarcinoma [0.03%]
整合多组学和机器学习揭示了肺腺癌吉非替尼耐药预后及治疗反应的标志物签名
Dong Zhou,Zhi Zheng,Yanqi Li et al.
Dong Zhou et al.
Gefitinib resistance (GR) presents a significant challenge in treating lung adenocarcinoma (LUAD), highlighting the need for alternative therapies. This study explores the genetic basis of GR to improve prediction, prevention, and treatment...
Role of the initiation factor 3 in the fidelity of initiator tRNA selection on ribosome [0.03%]
initiation因子3在起始tRNA选择准确性中的作用
Jitendra Singh,Umesh Varshney
Jitendra Singh
Initiation factors play critical roles in fine-tuning translation initiation, which is the first and the rate-limiting step in protein synthesis. In bacteria, initiation factors, IF1, IF2 and IF3 work in concert to accurately position the i...
YTHDF3 rs7464 A > G polymorphism increases Chinese neuroblastoma risk: A multiple-center case-control study [0.03%]
中国多中心队列研究发现YTHDF3基因rs7464A>G多态性增加神经母细胞瘤发病风险
Huiran Lin,Yongping Chen,Liping Chen et al.
Huiran Lin et al.
Neuroblastoma (NB), a rare childhood cancer originating in nerve tissue. YTHDF3, a member of the YTH domain protein family, is involved in RNA m6A modification and cancer progression. Polymorphisms in YTHDF3 may influence its expression and...
Multicenter Study
IUBMB life. 2025 Jan;77(1):e2923. DOI:10.1002/iub.2923 2025
KRT80 in hepatocellular carcinoma plays oncogenic role via epithelial-mesenchymal transition and PI3K/AKT pathway [0.03%]
KRT80通过上皮间质转化和PI3K/AKT途径在肝细胞癌中发挥致癌作用
Ruheng Hua,Xiyue Yan,Jun He et al.
Ruheng Hua et al.
Hepatocellular carcinoma (HCC), a globally prevalent form of cancer, is featured by aggressive growth and early metastasis. Elucidating the underlying mechanism and identifying the effective therapy are critical for advanced HCC patients. I...
Depletion of macrophages and osteoclast precursors mitigates iron overload-mediated bone loss [0.03%]
巨噬细胞和破骨前体细胞的耗竭缓解了铁过载介导的骨质流失
Vanessa Passin,Maria G Ledesma-Colunga,Sandro Altamura et al.
Vanessa Passin et al.
Iron is an essential element for physiological cellular processes, but is toxic in excess. Iron overload diseases are commonly associated with low bone mass. Increased bone resorption by osteoclasts as well as decreased bone formation by os...
KGF secreted from HSCs activates PAK4/BMI1, promotes HCC stemness through PI3K/AKT pathway [0.03%]
肝窦内皮细胞分泌的KGF通过PI3K/AKT途径激活PAK4/BMI1促进HCC干细胞特性的发展
Qinghua Li,Qiuyang Chen,Wenchao Wang et al.
Qinghua Li et al.
In our present study, we investigated the interaction between HSCs and HCC, also explored the molecular mechanism. Clinical samples were collected from HCC and adjacent tissue with different degree of liver fibrosis. HCC cells were co-cultu...
RETRACTION: Nutritional Flavonoids Modulate Estrogen Receptor α Signaling [0.03%]
撤稿：营养类黄酮调节雌激素受体α信号通路
F. Virgili , F. Acconcia , R. Ambra , A. Rinna , P. Totta , and M. Marino , "Nutritional Flavonoids Modulate Estrogen Receptor α Signaling," IUBMB Life 56, no. 3 (2004): 145-151, https://doi.org/10.1080/15216540410001685083. The above arti...
Retraction of Publication
IUBMB life. 2025 Jan;77(1):e2926. DOI:10.1002/iub.2926 2025
Hong Zhang,Jiqiang Ling
Hong Zhang
Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes to support protein synthesis in all organisms. Recent studies, empowered by advancements in genome sequencing, have uncovered an increasing number of disease-causing mutations in aaRS...