Oncogenic Role of PTPN14 in Pancreatic Cancer Through β-Catenin/NF-κB Pathway Activation [0.03%]
PTPN14通过β-catenin/NF-κB途径激活在胰腺癌中的致癌作用
Danni Luo,Xiaopan Luo,Shaojie Qian et al.
Danni Luo et al.
Pancreatic cancer (PC) is one of the deadliest malignancies due to early metastasis, therapy resistance, and a highly immunosuppressive microenvironment. Although oncogenic mutations such as KRAS and TP53 are well characterized, the role of...
Silent Guardians Gone Rogue: The Role of PIWI and piRNA in Malignant Transformation [0.03%]
由PIWI和piRNA诱导的恶性转化：寂静的守护者变身叛逆者？
Anthony Lalruatfela,Priyajit Biswal,Subham Kumar Behera et al.
Anthony Lalruatfela et al.
Malignant transformation is not merely the consequence of stochastic genetic mutations but rather a convergence of complex interplay between genetic, epigenetic, and environmental factors that collectively reprogram normal cells into cancer...
G-Patch Domain-Containing Protein 2, Transcriptionally Activated by YY1, Facilitates the Progression of Hepatocellular Carcinoma by Boosting SNAI2 Expression [0.03%]
转录因子YY1通过激活G-Patch域含蛋白2促进SNAI2表达从而推动肝癌进展
Beibei Bie,Hong Bai,Yingnan Li et al.
Beibei Bie et al.
G-patch domain-containing protein 2 (GPATCH2), a member of the G-patch domain-containing family, has been implicated in tumor cell growth, but the link between GPATCH2 and hepatocellular carcinoma (HCC) remains uncertain. In the current stu...
MTFR1 Promotes Proliferation and Metastasis of Triple-Negative Breast Cancer by Regulating Mitochondrial Metabolism [0.03%]
MTFR1通过调节线粒体代谢促进三阴性乳腺癌的增殖和转移
Zhengzhi Zhu,Jing Wang,Jianjun Liu et al.
Zhengzhi Zhu et al.
Mitochondria, as the center of cellular energy metabolism, play multiple key roles in the progression of triple-negative breast cancer (TNBC). Mitochondrial fission regulator 1 (MTFR1) is a mitochondrial regulatory factor that plays a part ...
MIA3 in Coronary Artery Disease (CAD): An In-Depth Review of Its Role in Vascular Smooth Muscle Cell (VSMC) Homeostasis, Pathogenesis, and Its Therapeutic Potential [0.03%]
MIA3在冠心病（CAD）中的作用：其在血管平滑肌细胞稳态、发病机制及治疗潜力的深入综述
Yousuf Tahir Ali,Aarthi Ravindran,Luis Eichelmann et al.
Yousuf Tahir Ali et al.
A significant portion of fatalities from coronary artery disease (CAD) has been attributed to be primarily triggered by atherosclerosis. The melanoma inhibitory activity protein-3 (MIA3) gene has been found to be a key regulator for plaque ...
Next-Generation Nanomaterials in Biology: From Tissue Regeneration to Targeted Cancer Therapy [0.03%]
下一代纳米材料在生物学中的应用：从组织再生至靶向癌症治疗
Debyashreeta Barik,V Badireenath Konkimalla
Debyashreeta Barik
The rapid advancement of nanotechnology has ushered in a new era of biomedical innovation, where nanomaterials serve as powerful tools at the interface of tissue regeneration and targeted cancer therapy. This review explores the dual roles ...
Integrated Multiomics Analysis and Mendelian Randomization Identify SIRT1 as a Pivotal Aging-Associated Gene in Meningioma [0.03%]
整合多组学分析和孟德尔随机化确定SIRT1是脑膜瘤中的一个关键衰老相关基因
Guangyu Du,Daikang Xu,Jingxian Sun et al.
Guangyu Du et al.
Meningiomas (MGMs) are the most prevalent benign intracranial tumors in adults, with incidence markedly increasing with age, underscoring the need to explore aging-associated molecular mechanisms. In this study, we integrated transcriptomic...
4-Methylumbelliferone Sensitizes Breast Cancer Spheroids to Chemotherapeutic Treatment With Epirubicin: New Perspectives for Pharmacological Repositioning [0.03%]
4-甲基香豆素素使乳腺癌细胞球对表柔比星化疗增敏：药物再定位的新视角
Daiana Luján Vitale,Antonella Icardi,Paolo Rosales et al.
Daiana Luján Vitale et al.
Chemoresistance remains a significant hurdle in breast cancer treatment. To address this, we explored the therapeutic potential of combining epirubicin, an anthracycline commonly associated with the development of resistance in cancer cells...
Critical Contribution of Various Signaling Pathways in the Development of Drug Resistance in Colorectal Cancer: An Update [0.03%]
结直肠癌药物耐药发生发展中多种信号通路的关键作用：进展报告
Mehran Molavand,Maryam Majidinia,Bahman Yousefi
Mehran Molavand
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide, with drug resistance being a major challenge in limiting the available treatment options. This review focuses on the signaling pathways (Hedgehog, Hippo...
CDCA4/SERTAD1/E2F1 Facilitates Lung Adenocarcinoma Progression by Inhibiting PINK1/Parkin-Mediated Mitophagy [0.03%]
CDCA4/SERTAD1/E2F1通过抑制PINK1/Parkin介导的线粒体自噬促进肺腺癌进展
Jianlong Tan,Jufen Wang,Weidong Zhang et al.
Jianlong Tan et al.
Cell division cycle-associated protein 4 (CDCA4) has the potential to indicate lung adenocarcinoma (LUAD) development, but its regulatory role in mitophagy remains unclear. This study aimed to elucidate the mitophagy regulation and therapeu...