Exercise as a Programmable Regulator of Mitophagy Sensitivity in Aging Muscle and Age-Related Disease [0.03%]
运动通过调节线粒体自噬敏感性可编程改善与衰老相关的肌肉功能下降
Peng Ran,Lifang Yang
Peng Ran
Aging is increasingly recognized as a systems-level process marked by progressive deterioration of mitochondrial performance in tissues with high energetic demand, placing skeletal muscle at the center of systemic metabolic and functional d...
LncRNA-ATB Orchestrates Tumor Growth and Immune Responses Through the Modulation of IGF2BP2 in Non-Small-Cell Lung Cancer [0.03%]
长链非编码RNA-ATB通过调控IGF2BP2在非小细胞肺癌中协同调控肿瘤生长和免疫应答
Shifang Sun,Hailin Chen,Shanshan Rong et al.
Shifang Sun et al.
Long non-coding RNAs (lncRNAs) are known to play a vital role in regulating tumorigenesis. Previous studies have shown that long non-coding RNA modulated by transforming growth factor-beta (lncRNA-ATB) is overexpressed in non-small-cell lun...
Non-Telomeric Role of RAP1 in Facilitating NF-κB Activation and Driving Hepatocellular Carcinoma Progression [0.03%]
RAP1通过促进NF-κB活化并驱动肝癌进展发挥端粒外功能
Rui Liu,Nannan Fu,Shuang Li et al.
Rui Liu et al.
RAP1 (TERF2IP) is a component of the shelterin complex that protects telomeric DNA and preserves chromosome stability. In addition to its telomeric function, accumulating evidence indicates that mammalian RAP1 also exerts multiple extra-tel...
Half-Life as a Therapeutic Design Axis: Targeting Short-Lived lncRNAs With Antisense Oligonucleotides [0.03%]
寿命作为治疗性设计轴：使用反义寡核苷酸靶向短寿命lncRNA
Hidenori Tani
Hidenori Tani
Engineering RNA stability has become a cornerstone of modern therapeutics, almost entirely in one direction: mRNA vaccines established stabilisation of exogenous transcripts as a powerful design axis. The symmetric operation-exploitation of...
ALKBH4 Promotes Osteogenesis via Epigenetic Regulation of BMP2-Wnt/β-Catenin Signaling in Cervical Spine OPLL [0.03%]
ALKBH4通过表观遗传调控BMP2-Wnt/β-catenin信号通路促进颈椎骨桥病的成骨作用
Haiyan Qiu,Yanze Lin,Xun Wang et al.
Haiyan Qiu et al.
DNA N6-methyladenine (6 mA) has recently been recognized as a novel epigenetic modification, with ALKBH4 identified as a specific demethylase. However, the role of ALKBH4 and DNA 6 mA in the pathogenesis of ossification of the posterior lon...
Single-Sequence Deep Learning Delivers Crystal-Quality Models of Covalent K-Ras G12 Hotspot Complexes [0.03%]
单序列深度学习提供共价K-Ras G12热点复合物的晶体质量模型
Sungwon Jung,Qinheng Zheng,Kevan M Shokat
Sungwon Jung
Structure-based design of covalent drugs has achieved tremendous success by understanding and leveraging the three-dimensional interactions between small-molecule drug candidates and their protein targets. However, this approach traditional...
Mechanism of PCSK9-Mediated Macrophage Activation via the CAP1/NF-κB Pathway in CAWS-Induced Kawasaki Disease Vasculitis [0.03%]
CAP1 / NF- κ B信号通路介导的PCSK9在CAWS诱导的川崎病血管炎巨噬细胞活化中的机制研究
Hao Zhang,Dujuan Shuai,Miaohua Ruan et al.
Hao Zhang et al.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) acts as a pleiotropic modulator of inflammation. This study aimed to investigate the role and underlying mechanism of PCSK9 in Kawasaki disease (KD)-associated vasculitis. A Candida albi...
Hormesis and the Golden Ratio: Toward a Universal Estimator of Adaptive Capacity [0.03%]
hormesis与黄金比例：走向适应能力的通用估计量
Evgenios Agathokleous
Evgenios Agathokleous
Hormesis represents a universal feature of biological plasticity across species and environmental contaminants. Here I propose that the maximum stimulatory peak converges upon the golden ratio (φ = 1.618), representing a 61.8% increase abo...
MicroRNAs in HPV-Associated Carcinogenesis: Potential Biomarkers in Oropharyngeal and Cervical Cancers [0.03%]
人乳头瘤病毒相关致癌过程中微小核糖核酸的作用及在口咽癌和宫颈癌中的潜在生物标志物功能
Rabab S Hamad,Ahmed S Doghish,Sherif S Abdel Mageed et al.
Rabab S Hamad et al.
High-risk human papillomavirus (HPV) infection is a key etiological factor in cervical cancer (CC) and oropharyngeal squamous cell carcinoma (OPSCC). Increasing evidence indicates that host microRNAs (miRNAs) are central regulators in HPV-i...
PGAM1 Orchestrates Cell Cycle Progression, Glycolytic Reprogramming, and Immunosuppressive Microenvironment in Triple-Negative Breast Cancer [0.03%]
PGAM1在三阴性乳腺癌中的作用：调控细胞周期进展、糖酵解重组和免疫抑制微环境
Shunshun Zhang,Xuewei Zheng,Siya Tang et al.
Shunshun Zhang et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by uncontrolled cell cycle progression, profound metabolic reprogramming, and immune evasion, yet effective therapeutic targets remain limited. In ...