Investigation on LASSBio-1971 and LASSBio-1974 Cellular Cytotoxic Mechanism and Their Comparative DMPK Profile [0.03%]
LASSBio-1971和LASSBio-1974细胞毒机制研究及其比较DMPK性质
Manoel Oliveira de Moraes Junior,Gisele Barbosa,Caroline Marques Xavier da Costa et al.
Manoel Oliveira de Moraes Junior et al.
Due to the arising of clinically relevant resistant EGFR-related phenotype through innovative mechanisms, mainly EGFRL858R/T790M, the emergence of novel molecules with dual or multi-target affinity has presented a promising alternative to o...
Comparative Study
Archiv der Pharmazie. 2025 Nov;358(11):e70151. DOI:10.1002/ardp.70151 2025
Hypoglycemic and Analgesic Effects of Benzyloxyphenylpropanoic Derivatives of Isobornylamine as FFAR-1 Agonists [0.03%]
Mariya A Elkina,Mikhail V Khvostov,Sergey O Kuranov et al.
Mariya A Elkina et al.
Type 2 diabetes mellitus (T2DM) is considered the "pandemic of the 21st century." It is a complex multifactorial disease associated with chronic hyperglycemia, causing further complications that result in disability and early mortality. Due...
The Role of PI3K Inhibition in Suppressing Pancreatic Cancer Progression: Mechanistic Insights From Copanlisib Studies [0.03%]
PI3K抑制在胰腺癌进展中的作用：Copanlisib研究的机制见解
Li Yu,Jiayao Wu,Shijie Wan et al.
Li Yu et al.
Accumulating evidence has demonstrated that the overactivation of phosphoinositide 3-kinase (PI3K) is closely linked to the development and progression of pancreatic cancer, establishing it as a potential therapeutic target. Although severa...
Comparative Efficacy of Donepezil and Lamotrigine in Modulating NFκB, PPARγ, and NLRP3 Inflammasome Pathways in Experimental Colitis [0.03%]
多奈哌齐和拉莫三嗪在实验性结肠炎中调节NFκB、PPARγ和NLRP3炎性小体通路的疗效比较
Nourhan S Abdeltwab Desoky,Maha A E Ahmed,Basma Emad Aboulhoda et al.
Nourhan S Abdeltwab Desoky et al.
Ulcerative colitis (UC) is a persistent inflammatory bowel disorder characterized by systemic inflammation and oxidative stress. This study compared the therapeutic potential of lamotrigine and donepezil in an acetic acid (AA)-induced UC ra...
Design, Synthesis, and Pharmacological Evaluation of Prenylated Arylidene-Substituted Thiazolidinedione-Based Pancreatic Lipase Inhibitors as Anti-obesity Agents [0.03%]
设计、合成及药理学评价一系列新双功能化焦谷酸内酯衍生物作为抗肥胖药物的研究
Rakesh Khator,Utkarsh A Jagtap,B Lavanya et al.
Rakesh Khator et al.
In the current study, a series of 22 prenylated arylidene appended thiazolidinedione derivatives were designed, synthesized, and evaluated for pancreatic lipase (PL) inhibitory activity. The study led to the identification of compounds exhi...
Investigating the Hepatoprotective Properties of Entresto in Hepatic Ischemia-Reperfusion Injury in Rats: The Implication of TLR4/MYD88/NF-KB p-65 and PPAR-γ/HO-1/Nrf2 Pathways [0.03%]
评估Entresto在大鼠肝缺血再灌注损伤中保护肝脏的作用及TLR4/MYD88/NF-KB p-65和PPAR-γ/HO-1/Nrf2信号通路的介导作用
Alaa Abouelhamd,Dalia H Abu-Baih,Sara Mohamed Naguib Abdel-Hafez et al.
Alaa Abouelhamd et al.
Hepatic ischemia/reperfusion injury (IRI) is a major complication during liver surgery, transplantation, and trauma. This study investigated the potential hepatoprotective effects of Entresto (sacubitril/valsartan), a dual angiotensin recep...
Decoding Hypoxia-Induced Metabolomic Changes in Breast Cancer EVs and Their Functional Effects on Cancer Cells [0.03%]
乳腺癌EVs中缺氧诱导的代谢组变化的解码及其对癌细胞的功能影响
Ashish Sahu,Vaidehi Bhavsar,Ravindra Taware
Ashish Sahu
This study utilized an untargeted metabolomic approach using LC-MS/MS to analyze the metabolic alterations in extracellular vesicles (EVs) secreted by breast cancer cells under hypoxic conditions. EVs were isolated using an established ultr...
Ergosterol, a Novel RORγt Inverse Agonist, Enhances Skin Barrier Function and Reduces Skin Inflammation in IMQ-Induced Mice With Psoriasis [0.03%]
新型RORγt反向激动剂 Ergosterol 增强皮肤屏障功能并减少IMQ诱导的小鼠银屑病皮肤炎症
Ling Jiang,Jiangming Zhong,Huixiong Chen et al.
Ling Jiang et al.
Retinoic acid receptor-related orphan receptor gamma-t (RORγt) is one of the nuclear receptor transcription factors that plays a key role in the differentiation of pro-inflammatory IL-17+ T helper cells. Recently, RORγt has attracted incr...
Cumambrin B Alleviates Acute Lung Injury In Vivo and Attenuates NF-κB/MAPK-Mediated Inflammation and Oxidative Stress by Regulating the Accumulation of ROS In Vitro [0.03%]
Cumambrin B通过调节ROS积累来缓解急性肺损伤体内炎症和氧化应激NF-κB / MAPK介导的体内体外机制
Qianqian Ren,Yuemei Que,Xiaoran Min et al.
Qianqian Ren et al.
Acute lung injury (ALI) represents a critical medical issue typified by serious respiratory dysfunction, which frequently progresses to acute respiratory distress syndrome (ARDS), a condition linked to elevated rates of morbidity and mortal...
Pregnenolone Carbamate Derivatives as Selective Cholinesterase Inhibitors: Multimodal Evaluation Including DNA and HSA Interactions [0.03%]
作为选择性胆碱酯酶抑制剂的孕烯醇酮碳氢酸衍生物：包括DNA和HSA相互作用在内的多模式评估
Sura Akca,Sevinc Ilkar Erdagi,Duygu Inci Ozbagci
Sura Akca
Pregnenolone-carbamate derivatives were synthesized and evaluated as potential multifunctional agents with cholinesterase inhibitory and neuroprotective properties. Among them, P3, P5, and P9 exhibited the most promising profiles and were s...