Indole-Based Curcumin Analogs With Antioxidant and Antitumor Activities: Synthesis, Molecular Docking [0.03%]
Zhipeng Huang,Shuzhao Wang,Rongming Yu et al.
Zhipeng Huang et al.
Curcumin, a natural compound with broad pharmacological effects, suffers from low bioavailability due to its unstable β-diketone structure. To address this, we designed novel indole-based curcumin analogs via molecular hybridization, repla...
Ferroptosis-Driven Anticancer Activity of 1,3,4-Oxadiazole-Benzimidazole/Acetamide Hybrids: Design, Synthesis, and Biological Profiling [0.03%]
Fatma Fouad Hagar,Amer Ali Abd El-Hafeez,Samar H Abbas et al.
Fatma Fouad Hagar et al.
A series of 1,3,4-oxadiazole-benzimidazole/acetamide derivatives (7a-r) was designed, synthesized, and evaluated for their anticancer activity. NCI-screening results at 10 µM against the 60 human tumor cell line panel revealed a broad-spec...
Evaluation of Amikacin Mediated Platelet Aggregate Dissociation in Multi-Anticoagulant-Dependent Pseudothrombocytopenia (PTCP) [0.03%]
Bo Wang,Junwen Liu,Wenying Yao et al.
Bo Wang et al.
Anticoagulant-dependent pseudothrombocytopenia (PTCP) is an in vitro artifact that leads to falsely low platelet counts. To evaluate the efficacy of Amikacin in reversing platelet (PLT) clumping induced by various anticoagulants, including ...
Exploring Novel Nitrofuryl-1,3,4-Thiadiazole-Based Derivatives: Design, Synthesis, and Evaluation of In Vitro Leishmanicidal and Trypanocidal Activity [0.03%]
Alireza Mousavi,Martina Slapničková,Maryam Norouzbahari et al.
Alireza Mousavi et al.
Neglected tropical diseases remain a major global health challenge, highlighting the need for new antiparasitic agents. In this study, a series of substituted 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]piperidine-4-carboxamides was desi...
AXL and c-Met Dual-Targeting in Non-Small Cell Lung Cancer: A Review of Small-Molecule Inhibitors and Their Structure-Activity Relationships [0.03%]
Haifeng Dong,Mengting Yu,Yanyun Hong et al.
Haifeng Dong et al.
AXL and c-Met have been identified as pivotal oncogenic factors in non-small cell lung cancer (NSCLC), their downstream signaling pathways exhibit substantial cross-talk, and the simultaneous inhibition of both factors has demonstrated subs...
Advances in Pyrazolopyrimidine Scaffold: Synthetic Strategies and Biological Applications (2019-Present) [0.03%]
Anshul Bansal,Virender Kumar,Ranjana Aggarwal et al.
Anshul Bansal et al.
The pyrazolopyrimidines are a significant category of heterocyclic fused compounds that have gained growing interest owing to their wide range of biological functions as well as their synthetic all-purpose. The review draws attention to the...
Chromones as Nonclassical Inhibitors of Carbonic Anhydrase IX and XII Isoforms: Probing Chromone-Based Derivatives [0.03%]
色酮作为非经典的碳酸酐酶IX和XII同工酶抑制剂：探究基于色酮的衍生物
Lisa Sequeira,Simona Distinto,Carlos Fernandes et al.
Lisa Sequeira et al.
A small library of differently substituted chromones was successfully synthesized and structurally characterized. All compounds were evaluated for their inhibitory potency and selectivity toward human cancer-associated carbonic anhydrase is...
Developments on BACE 1 Inhibitors as Anti-Alzheimer Agents: A Perspective on Medicinal Chemistry-Based Advances [0.03%]
基于药物化学的β分泌酶1抑制剂抗阿尔茨海默病新药研究进展透视
Nemat Ali,Fahad T Alotaibi,M Arockia Babu et al.
Nemat Ali et al.
Alzheimer's disease (AD) is a progressive and complicated neurodegenerative disorder that mostly affects the elderly and is characterized by memory loss, cognitive dysfunction, accumulation of amyloid beta (Aβ) plaques, neurofibrillary tan...
AI-Based Prediction of PROTAC- and Molecular Glue-Mediated Ternary Complexes: A Comparative Evaluation of AlphaFold 3 and Boltz-2 [0.03%]
基于人工智能的PROTAC和分子胶介导的三元复合物预测：AlphaFold 3与Boltz-2的比较评估
Lino Riepenhausen,Anne-Christin Sarnow,Dina Robaa et al.
Lino Riepenhausen et al.
Proteolysis targeting chimeras (PROTACs) and molecular glues induce ligand-mediated ternary complexes between an E3 ubiquitin ligase and a protein of interest, but their in silico modeling remains challenging due to conformational flexibili...
Comparative Study
Archiv der Pharmazie. 2026 Mar;359(3):e70225. DOI:10.1002/ardp.70225 2026
A Review on Isoniazid and Rifampicin-Associated Hepatotoxicity: From Metabolism to Immunity [0.03%]
异烟肼和利福平肝毒性的代谢与免疫研究进展
Zahra Batool,Qihang Wu,Guobin Weng et al.
Zahra Batool et al.
Isoniazid (INH) and rifampicin (RIF) are cornerstone first-line antituberculosis drugs, yet their clinical utility is often limited by drug-induced liver injury (DILI). Understanding the mechanistic basis of INH and RIF-induced hepatotoxici...