Navigating the p53-MDM2 Landscape: Molecular Insights and Therapeutic Strategies [0.03%]
p53-MDM2信号通路的调控机制与肿瘤治疗策略研究
Mai A Mansour,Ghaneya S Hassan,Khaled A M Abouzid
Mai A Mansour
MDM2 is categorised as a critical oncogenic regulator that negatively controls the tumour suppressor p53, making it an important target for cancer therapy. With the aim of restoring the p53 activity through disrupting MDM2-p53 interaction, ...
Recent Advances on the Molecular Mechanisms of Apoptosis Induced by Natural Product Oridonin and Its Derivatives [0.03%]
青蒿素及其衍生物诱导凋亡的分子机制研究进展
Tian Gao,Yi Mei,Jinyi Xu et al.
Tian Gao et al.
Oridonin, a bioactive ent-kaurane diterpenoid derived from Rabdosia rubescens, has attracted considerable attention as a promising anti-cancer candidate. Its diverse functional groups and favorable physicochemical properties provide multipl...
Inhibition of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1): A Medicinal Chemistry Approach at the Crossroad of Immunotherapy and Metabolic Modulation [0.03%]
免疫疗法和代谢调节交叉口的ectonucleotide pyrophosphatase/phosphodiesterase 1（enpp1）抑制：药物化学方法
Abdur Rauf,Md Rezaul Islam,Alessandra Gianoncelli et al.
Abdur Rauf et al.
The ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) family regulates critical processes, including nucleotide signaling, bone mineralization, and tumor immune infiltration. Consequently, ENPP1 is recently being re-discovered as a no...
Covalent Molecular Glues: Mechanisms, Design Principles, and Emerging Therapeutic Opportunities in Targeted Protein Degradation [0.03%]
共价分子胶：靶向蛋白降解中的作用机制、设计原则和新兴治疗机会
Ahmed A Al-Karmalawy,Mohamed Ibrahim Attia,Tarek A Yousef et al.
Ahmed A Al-Karmalawy et al.
Targeted protein degradation (TPD) has revolutionized modern drug discovery by enabling the catalytic and selective removal of disease-driving proteins that are beyond the reach of traditional inhibition. Among emerging TPD modalities, cova...
Protein-Protein Interaction as an Efficient Target to Inhibit HIV-1 Integrase [0.03%]
以蛋白质相互作用作为高效抑制HIV-1整合酶的靶点
Afshin Zarghi,Zahra Hajimahdi
Afshin Zarghi
Human immunodeficiency virus (HIV) infection remains a major global health concern, affecting nearly 40 million people worldwide. Therefore, discovering new therapeutic targets against HIV is still a continued demand. HIV integrase, an esse...
Wanqing Zheng,Kuan Zhang,Xianghui Fan et al.
Wanqing Zheng et al.
Cancer poses a devastating global threat, inflicting immense physical suffering, high mortality rates, severe psychological distress, and substantial economic burdens on individuals, families, and healthcare systems worldwide while gravely ...
Tamoxifen-Based Dimers: Design, Synthesis, Cell Viability Evaluation on Breast Cancer Cells, and Computational Insights [0.03%]
基于他莫昔芬的二聚体：设计、合成、乳腺癌细胞活性评价及计算化学研究
Berrak Ertugrul,Abdulmelik Aytatli,Omer Faruk Karatas et al.
Berrak Ertugrul et al.
Tamoxifen (TMX) resistance presents a significant challenge in the treatment of ER+ breast cancer. In this study, four novel tamoxifen-based dimers were synthesized and evaluated for their antitumor activities. Among these, (Z,Z)-1 exhibite...
Design and Synthesis of Novel Pyridazinone Derivatives as Cardiac Myosin Activator for the Systolic Heart Failure [0.03%]
新型吡啶并咪唑衍生物作为心脏肌球蛋白激活剂治疗收缩性心力衰竭的研究及合成
Meng Sun,Qiming Li,Ke Chen et al.
Meng Sun et al.
Reduced cardiac contractility characterizes systolic heart failure. Current drugs elevate cAMP or calcium but increase myocardial oxygen consumption, cause arrhythmias, and have poor long-term outcomes. To overcome these limitations, in thi...
Lycorine: From Extraction and Synthesis to Formulation Development-Research Challenges and Advances in Pharmacological Mechanisms and Clinical Translation [0.03%]
石蒜碱：从提取和合成到制剂开发——药理机制与临床转化研究挑战及进展
Cong Zhang,Chenchen Yu,Chungang Zhang et al.
Cong Zhang et al.
Lycorine, a natural alkaloid derived from plants of the lycoris genus, has attracted considerable attention in antiviral, antitumor, and anti-inflammatory research due to its distinctive chemical architecture and broad-spectrum bioactivitie...
Identification of Ferroptosis as a Novel Mechanism for Antitumor Activity of 2-phenylphthalazin-2-iums in Breast Cancer [0.03%]
识别2-苯基菲拉嗪作为乳腺癌抗肿瘤活性的新机制铁死亡
Fang-Jun Cao,Hui Zhang,Tie-Zhi Jin et al.
Fang-Jun Cao et al.
Quaternary benzo[c]phenanthridine alkaloids (QBAs), an important class of natural isoquinoline alkaloids, possess potential multiple anti-cancer activities. By structural simulation, 29 2-phenylphthalazin-2-iums with anti-cancer effects wer...