Novel Kojic Acid-Thiadiazole-Urea Hybrids: Potent Tyrosinase Inhibitors With Enhanced Anti-Melanogenic Activity [0.03%]
新型曲酸-噻二唑-脲衍生物：一种高效抑制酪氨酸酶的抗黑素活性化合物研究
Ayyub Mojaddami,Mojtaba Hamzi,Mehdi Khoshneviszadeh et al.
Ayyub Mojaddami et al.
A new class of kojic acid-derived tyrosinase inhibitors was rationally designed through the incorporation of a thiadiazole-urea framework. Accordingly, a series of 1-(aryl)-3-(5-{[(5-hydroxy-4-oxo-4H-pyran-2-yl)methyl]thio}-1,3,4-thiadiazol...
Exploring Nirmatrelvir Derivatives Through P2 Substituent Modifications and Warhead Innovations Targeting the Main Protease of SARS-CoV-2 [0.03%]
通过P2位取代基变化和战头创新探索SARS-CoV-2主要蛋白酶的奈玛特韦衍生物研究
Felipe Cardoso Prado Martins,Johannes Lang,Fernanda Dos Reis Rocho et al.
Felipe Cardoso Prado Martins et al.
The COVID-19 pandemic underscored the urgent need for effective antiviral agents, particularly against coronaviruses, which pose a continuing threat of future outbreaks. Targeting the main protease (Mpro), a key enzyme in viral replication,...
Synthesis of Promising Biguanide Derivatives Bearing Urea/Thiourea as Type II Antidiabetic Agents [0.03%]
一类新型含脲和硫脲结构的双胍衍生物抗糖尿病药物的设计、合成与活性研究
Wahid M Basyouni,Samir Y Abbas,Eman A Younis et al.
Wahid M Basyouni et al.
Novel biguanide hydrochloride salts were synthesized through the reaction of N-substituted-semi(thiosemi)carbazides with cyanoguanidine in an acidic medium. Antidiabetic properties of the synthesized biguanides were evaluated for their anti...
Comparative Study
Archiv der Pharmazie. 2025 Nov;358(11):e70150. DOI:10.1002/ardp.70150 2025
Bruceantin and Brusatol: Molecular Insights and Therapeutic Promise of Quassinoids in Cancer Drug Discovery [0.03%]
Brucea江南风格的分隔符jin抗肿瘤活性成分研究及抗癌药物发现分子机制探究
Shumaila Ijaz,Javed Iqbal,Banzeer Ahsan Abbasi et al.
Shumaila Ijaz et al.
Cancer remains a leading cause of mortality worldwide, with treatment resistance posing a major obstacle to effective therapies. Natural compounds, including quassinoids such as bruceantin and brusatol, derived from Brucea javanica (L.) Mer...
Indole Hybrids With Therapeutic Potential Against Drug-Resistant Cancers: An Update (2021-2025) [0.03%]
具有治疗耐药癌症潜力的吲哚杂化物（2021-2025）最新研究进展
Xiaoyu Li,Feng Wang,Lin Xie
Xiaoyu Li
Drug-resistant cancer is a major obstacle to effective treatment, causing poor clinical outcomes, financial pressure, and healthcare burdens, highlighting the urgent need for new chemotherapeutics. Indole derivatives are valuable anticancer...
Identification and Validation of Novel Lactylation-Related Gene Signature in Dilated Cardiomyopathy [0.03%]
鉴定并验证扩张型心肌病中新的乳酰化相关基因特征标志物
Jia Liu,Chong Liu,Jingjia Yu et al.
Jia Liu et al.
Dilated cardiomyopathy (DCM) is a progressive myocardial disorder with limited therapeutic options. Recent studies suggest that metabolic reprogramming, including lactate accumulation and protein lactylation, contributes to heart failure pa...
Microwave-Enhanced Synthesis of 2-Styrylquinoline-4-Carboxamides With Promising Anti-Lymphoma Activity [0.03%]
微波促进合成具有抗淋巴癌活性的2-苯并烯基喹啉-4-甲酰胺类化合物
Ignazio Sardo,Lorenzo Manfreda,Giulia Maria Titone et al.
Ignazio Sardo et al.
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, characterized by significant clinical and molecular heterogeneity. Here, we report the design and synthesis of a novel series of 2-styrylquinoline-4-c...
Erratum: Investigating the Hepatoprotective Properties of Entresto in Hepatic Ischemia-Reperfusion Injury in Rats: The Implication of TLR4/MYD88/NF-KB p-65 and PPAR-γ/Ho-1/Nrf2 Pathways [0.03%]
他图特：探究Entresto在大鼠肝缺血再灌注损伤中的肝保护作用及其TLR4/MYD88/NF-KB p-65和PPAR-γ/Ho-1/Nrf2通路的介导效应论文的勘误表
Published Erratum
Archiv der Pharmazie. 2025 Nov;358(11):e70160. DOI:10.1002/ardp.70160 2025
Identification of Novel β-Lactam Derivatives as Proteasome Inhibitors for Antitumor Therapy [0.03%]
用于抗肿瘤治疗的新型β-内酰胺衍生物作为蛋白酶体抑制剂的鉴定
Yu Cao,Gaoya Xu,Lixin Gao et al.
Yu Cao et al.
A series of dipeptidic proteasome inhibitors with β-lactam as the C-terminus was designed and synthesized. Biochemical evaluations of their effects on chymotrypsin-like (CT-L) activity revealed that some of them had inhibitory activity aga...
Design, Synthesis, Biological Evaluation, and In Silico Studies of Novel Furo[2,3-d]pyrimidine Derivatives as EGFR Inhibitors With Potential Antitumor Activity [0.03%]
新型呋喃并[2,3-d]嘧啶衍生物作为EGFR抑制剂的抗肿瘤活性的设计、合成、生物学评价及计算机模拟研究
Samar I Faggal,Walid E Elgammal,Amr Sonousi et al.
Samar I Faggal et al.
In the pursuit of developing targeted therapies, novel furo[2,3-d]pyrimidine compounds were synthesized, incorporating the characteristic structural features of EGFR tyrosine kinase inhibitors. These compounds were screened for antiprolifer...