Current Landscape and Therapeutic Prospects of Indole Hybrids for Colorectal Cancer Treatment [0.03%]
吲哚杂化衍生物在结直肠癌治疗领域的研究进展与前景展望
Zhendong Xu,Juntao Song,Fuhui Zhang et al.
Zhendong Xu et al.
Colorectal cancer (CRC), a malignant tumor originating from the colon or rectum epithelium, is one of the most prevalent and lethal gastrointestinal cancers globally, with its pathogenesis closely linked to genetic mutations and dysregulate...
A Proteochemometric Model for Ligands of the SLC5 Transporter Family [0.03%]
SLC5家族转运蛋白配体的,protochemometric模型
Martin Juhás,Gerhard Ecker
Martin Juhás
The SLC5 family of solute carriers is of significant interest for drug development due to its role in many disease processes. Building on the recent elucidation of SGLT2's structure, we developed a proteochemometric model for SLC5 inhibitor...
Deciphering Anticoagulant Active Substances and Mechanisms in Guanxinjing Formula Through Phenotype-Anchored Hierarchical Strategy and Topological Network Analysis [0.03%]
基于表型导向的多层次策略和拓扑网络分析解读冠心静颗粒抗凝活性成分及机制研究
Yuanlin Luo,Xiaozhuan Jia,Hai Ren et al.
Yuanlin Luo et al.
Anticoagulation is the cornerstone for preventing thrombosis in coronary heart disease patients with atrial fibrillation or a mechanical heart valve. Guanxinjing formula (GXJF) demonstrates anticoagulant effects, while its anticoagulant sub...
New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti-Tumor Activity Against Ewing Sarcoma [0.03%]
一类新型具有良好NAK激酶选择性的喹啉类激酶抑制剂及其抗尤因肉瘤活性研究
Caroline de Bem Gentz,Thais Helena Maciel Fernandes,Marcela Silva Lopes et al.
Caroline de Bem Gentz et al.
In the past few years, several novel anticancer agents targeting protein kinases have been discovered expanding the available therapeutic arsenal. However, few new therapeutic approaches have been developed for the treatment of childhood ca...
Exploring Sulfonamides: Biological Activities and Structure-Activity Relationships [0.03%]
磺胺类药物的生物活性及构效关系研究
Souad Zerbib,Natália Cruz-Martins,Latifa Bouissane
Souad Zerbib
Sulfonamides (SNs) are a well-known class of antibiotics that have been explored in many areas of medicinal chemistry. Their broad spectrum of biological and medicinal properties, which includes antibacterial, anticancer, antifungal, anti-i...
Erratum: Support Vector Machine Identification of Small Molecule Binders to an Understudied Allosteric Site of SARS-CoV-2 Mpro for Next-Generation PROTAC-Based Therapeutics [0.03%]
Correction: 利用支持向量机在SARS-CoV-2 Mpro 的未被充分研究的别构位点中鉴定小分子配体以研发下一代靶向蛋白降解剂（PROTAC）疗法
Published Erratum
Archiv der Pharmazie. 2026 Jan;359(1):e70182. DOI:10.1002/ardp.70182 2026
Targeting TXNIP With Saroglitazar Mitigates Acute Hepatic Injury in Rats Challenged With Thioacetamide: A Multistep Computational and Experimental Approach [0.03%]
靶向TXNIP的萨罗格利扎然可减轻噻唑烷酮诱导的大鼠急性肝损伤：一种多步计算和实验方法
Fatma Elnaghy,Sameh Saber,Eman M Abd El-Kader et al.
Fatma Elnaghy et al.
Acute hepatic injury (AHI) is a sudden onset of hepatic inflammation, a key contributor to the progression of diabetes and other disorders. Diabetes mellitus also increases the risk of liver illnesses associated with inflammatory disorders....
Current Scenario of Hydroxamic Acid Derivatives With In Vivo Antitumor Therapeutic Potential [0.03%]
具有体内抗肿瘤治疗潜力的水杨酸衍生物的当前情况
Zhi Xu,Junna Liu
Zhi Xu
Cancer, as a fatal metastatic disease, exerts a deep-seated and extensive influence on human health, impacting not just the physical condition of patients but also their psychological state and social lives. Hydroxamic acid derivatives, as ...
Carboline Hybrids as Potential Multitarget-Directed Anti-Alzheimer's Disease Agents: A Comprehensive Analysis of Design Strategies and Structure-Activity Relationships [0.03%]
卡ボ琳杂化物作为潜在的多靶向抗阿尔茨海默病制剂：设计策略和构效关系的全面分析
Sandipan Dash,Arghya Kusum Dhar
Sandipan Dash
The β-carboline hybrids represent innovative therapeutics for Alzheimer's disease (AD) as multitarget-directed ligands (MTDLs), addressing cholinergic deficits through AChE/BuChE inhibition, amyloid-β (Aβ) aggregation, tau hyperphosphory...
Tetrazole Derivatives as Multiclass Inhibitors of Bacterial Carbonic Anhydrases [0.03%]
四氮唑衍生物作为细菌碳酸酐酶多靶标抑制剂
Andrea Ammara,Simone Giovannuzzi,Viviana De Luca et al.
Andrea Ammara et al.
This study investigates derivatives including a tetrazole zinc-binding group as inhibitors of the α-, β-, and γ-class carbonic anhydrase (CA) isoforms from pathogenic bacteria such as Vibrio cholerae, Escherichia coli, and Streptococcus ...