Microwave-Enhanced Synthesis of 2-Styrylquinoline-4-Carboxamides With Promising Anti-Lymphoma Activity [0.03%]
微波促进合成具有抗淋巴癌活性的2-苯并烯基喹啉-4-甲酰胺类化合物
Ignazio Sardo,Lorenzo Manfreda,Giulia Maria Titone et al.
Ignazio Sardo et al.
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, characterized by significant clinical and molecular heterogeneity. Here, we report the design and synthesis of a novel series of 2-styrylquinoline-4-c...
Erratum: Investigating the Hepatoprotective Properties of Entresto in Hepatic Ischemia-Reperfusion Injury in Rats: The Implication of TLR4/MYD88/NF-KB p-65 and PPAR-γ/Ho-1/Nrf2 Pathways [0.03%]
他图特：探究Entresto在大鼠肝缺血再灌注损伤中的肝保护作用及其TLR4/MYD88/NF-KB p-65和PPAR-γ/Ho-1/Nrf2通路的介导效应论文的勘误表
Published Erratum
Archiv der Pharmazie. 2025 Nov;358(11):e70160. DOI:10.1002/ardp.70160 2025
Identification of Novel β-Lactam Derivatives as Proteasome Inhibitors for Antitumor Therapy [0.03%]
用于抗肿瘤治疗的新型β-内酰胺衍生物作为蛋白酶体抑制剂的鉴定
Yu Cao,Gaoya Xu,Lixin Gao et al.
Yu Cao et al.
A series of dipeptidic proteasome inhibitors with β-lactam as the C-terminus was designed and synthesized. Biochemical evaluations of their effects on chymotrypsin-like (CT-L) activity revealed that some of them had inhibitory activity aga...
Design, Synthesis, Biological Evaluation, and In Silico Studies of Novel Furo[2,3-d]pyrimidine Derivatives as EGFR Inhibitors With Potential Antitumor Activity [0.03%]
新型呋喃并[2,3-d]嘧啶衍生物作为EGFR抑制剂的抗肿瘤活性的设计、合成、生物学评价及计算机模拟研究
Samar I Faggal,Walid E Elgammal,Amr Sonousi et al.
Samar I Faggal et al.
In the pursuit of developing targeted therapies, novel furo[2,3-d]pyrimidine compounds were synthesized, incorporating the characteristic structural features of EGFR tyrosine kinase inhibitors. These compounds were screened for antiprolifer...
Investigation on LASSBio-1971 and LASSBio-1974 Cellular Cytotoxic Mechanism and Their Comparative DMPK Profile [0.03%]
LASSBio-1971和LASSBio-1974细胞毒机制研究及其比较DMPK性质
Manoel Oliveira de Moraes Junior,Gisele Barbosa,Caroline Marques Xavier da Costa et al.
Manoel Oliveira de Moraes Junior et al.
Due to the arising of clinically relevant resistant EGFR-related phenotype through innovative mechanisms, mainly EGFRL858R/T790M, the emergence of novel molecules with dual or multi-target affinity has presented a promising alternative to o...
Comparative Study
Archiv der Pharmazie. 2025 Nov;358(11):e70151. DOI:10.1002/ardp.70151 2025
Hypoglycemic and Analgesic Effects of Benzyloxyphenylpropanoic Derivatives of Isobornylamine as FFAR-1 Agonists [0.03%]
Mariya A Elkina,Mikhail V Khvostov,Sergey O Kuranov et al.
Mariya A Elkina et al.
Type 2 diabetes mellitus (T2DM) is considered the "pandemic of the 21st century." It is a complex multifactorial disease associated with chronic hyperglycemia, causing further complications that result in disability and early mortality. Due...
The Role of PI3K Inhibition in Suppressing Pancreatic Cancer Progression: Mechanistic Insights From Copanlisib Studies [0.03%]
PI3K抑制在胰腺癌进展中的作用：Copanlisib研究的机制见解
Li Yu,Jiayao Wu,Shijie Wan et al.
Li Yu et al.
Accumulating evidence has demonstrated that the overactivation of phosphoinositide 3-kinase (PI3K) is closely linked to the development and progression of pancreatic cancer, establishing it as a potential therapeutic target. Although severa...
Comparative Efficacy of Donepezil and Lamotrigine in Modulating NFκB, PPARγ, and NLRP3 Inflammasome Pathways in Experimental Colitis [0.03%]
多奈哌齐和拉莫三嗪在实验性结肠炎中调节NFκB、PPARγ和NLRP3炎性小体通路的疗效比较
Nourhan S Abdeltwab Desoky,Maha A E Ahmed,Basma Emad Aboulhoda et al.
Nourhan S Abdeltwab Desoky et al.
Ulcerative colitis (UC) is a persistent inflammatory bowel disorder characterized by systemic inflammation and oxidative stress. This study compared the therapeutic potential of lamotrigine and donepezil in an acetic acid (AA)-induced UC ra...
Design, Synthesis, and Pharmacological Evaluation of Prenylated Arylidene-Substituted Thiazolidinedione-Based Pancreatic Lipase Inhibitors as Anti-obesity Agents [0.03%]
设计、合成及药理学评价一系列新双功能化焦谷酸内酯衍生物作为抗肥胖药物的研究
Rakesh Khator,Utkarsh A Jagtap,B Lavanya et al.
Rakesh Khator et al.
In the current study, a series of 22 prenylated arylidene appended thiazolidinedione derivatives were designed, synthesized, and evaluated for pancreatic lipase (PL) inhibitory activity. The study led to the identification of compounds exhi...
Investigating the Hepatoprotective Properties of Entresto in Hepatic Ischemia-Reperfusion Injury in Rats: The Implication of TLR4/MYD88/NF-KB p-65 and PPAR-γ/HO-1/Nrf2 Pathways [0.03%]
评估Entresto在大鼠肝缺血再灌注损伤中保护肝脏的作用及TLR4/MYD88/NF-KB p-65和PPAR-γ/HO-1/Nrf2信号通路的介导作用
Alaa Abouelhamd,Dalia H Abu-Baih,Sara Mohamed Naguib Abdel-Hafez et al.
Alaa Abouelhamd et al.
Hepatic ischemia/reperfusion injury (IRI) is a major complication during liver surgery, transplantation, and trauma. This study investigated the potential hepatoprotective effects of Entresto (sacubitril/valsartan), a dual angiotensin recep...