Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS-CoV-2 Vaccination [0.03%]
SARS-CoV-2疫苗接种后早期短暂产生的异质活化B细胞区室
Laura Fernandez Blanco,Lisan H Kuijper,Laura Y L Kummer et al.
Laura Fernandez Blanco et al.
In humans, the stages and dynamics of B cell development after antigen encounter remain unclear. Identifying early B cell differentiation stages could reveal biomarkers for humoral immunity and potential targets to prevent unwanted antibody...
Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota [0.03%]
携天然微生物组的小鼠脾脏免疫衰老及慢性应激适应的单细胞图谱分析
Chinna Susan Philip,Igor Filippov,Uku Haljasorg et al.
Chinna Susan Philip et al.
Immune ageing impairs adaptive and innate responses, yet the spleen remains underexplored by cross-cohort single-cell studies. We profiled splenocytes from young, old and chronically stressed old mice with natural microbiota using single-ce...
38-Marker Full-Spectrum Flow Cytometry Panel for the Comprehensive Profiling of γδ T Cells in Human Blood and Lymphoid Tissues [0.03%]
人血液和淋巴组织中γδT细胞综合分析的38联标志全面光谱流式检测面板
Mohamed Hamed,Daniela Moreno-Vicencio,Daniel Arsovski et al.
Mohamed Hamed et al.
This is an update to the Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies (Third Edition), Chapter 12C, by Cossarizza et al. A 38-marker full-spectrum flow cytometry panel enabling high-resolution profiling...
IL-33 Elicits LTC4 Synthesis in Allergic Inflammation via ST2-Mediated Activation of Eosinophils [0.03%]
IL-33通过ST2介导的活化促进嗜酸性粒细胞在过敏炎症中产生LTC4
Vitória F Rosário-Garcia,Ericka Guimaraes-Ferreira,Yasmin Brito-Leite et al.
Vitória F Rosário-Garcia et al.
Like pieces of a puzzle, IL-33, eosinophils, and cysteinyl leukotrienes seem to come together and orchestrate allergic inflammation. While the IL-33/ST2 receptor axis is known to activate some classical eosinophil functions, its ability to ...
Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation [0.03%]
一种靶向CD40-CD40L的新型抗体FAB片段可抑制B细胞活化和分化从而控制自身免疫反应
Kathrine Pedersen,Kenneth Green,Emil L Kristoffersen et al.
Kathrine Pedersen et al.
Dysregulation of the CD40-CD40L axis is implicated in autoimmune diseases. Early clinical trials targeting CD40L with antibodies failed due to Fc-mediated side effects. To address this, we developed an anti-CD40L Fab fragment, Fab20, design...
Type 1 and CD103+ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn's Disease [0.03%]
溃疡性结肠炎患者活动期Ⅰ型和CD103+Ⅱ型常规树突状细胞减少但克罗恩病患者不减少
Elisa Arribas-Rodríguez,Carolina G de Castro,Aida Fiz-López et al.
Elisa Arribas-Rodríguez et al.
This study aimed to characterize human intestinal conventional dendritic cells (cDCs) in health and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD). Three cDC subsets (CD103- cDC2, CD103+ cDC2, a...
Spatial Profiling of Germinal Centers in Mouse Secondary Lymphoid Organs Using MACSima Imaging Cyclic Staining Technology [0.03%]
利用MACSima成像循环染色技术研究小鼠次级淋巴器官中生发中心的空间分布特点
Isabel San Martín Molina,Hanneke Okkenhaug,Simon Walker et al.
Isabel San Martín Molina et al.
We developed a 50-plex imaging protocol using the MACSima platform to characterize the microarchitecture of germinal centers in secondary lymphoid tissues. This workflow combines tissue processing, automated cyclic imaging, image preprocess...
CD4+ T-Cell-Intrinsic IL-6 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell-Mediated Suppression [0.03%]
IL-6对于CD4+T细胞自身生成Th17及抑制对CD8+T细胞介导的应答至关重要
Chakrapani Vemulawada,Kshitija Kale,Michael P Crawford et al.
Chakrapani Vemulawada et al.
This study investigates the role of T-cell-intrinsic IL-6 in Th17 differentiation and effector resistance. Using CRISPR-Cas9-mediated Il6 knockdown in primary human CD4+ T-cells, we demonstrate that T-cell-produced IL-6 is crucial for the o...
Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening [0.03%]
通过化学文库筛选发现Lomitapine是一种新的肥大细胞调节剂
Shiori Mamorita,Atsushi Furukawa,Yuka Nagata et al.
Shiori Mamorita et al.
Allergic diseases are a global health concern, and new molecular insights and therapeutic agents are necessary to support future research and interventions. Mast cells (MCs) play a crucial role in allergic reactions, in which antigen (Ag) c...
Latent, Lytic, and Linked to Multiple Sclerosis-How EBV Drives Autoimmunity [0.03%]
隐形、溶损和与多发性硬化症相关的是如何EB病毒驱动自身免疫反应
Fabienne Läderach,Elena Bremer,Christian Münz
Fabienne Läderach
Epstein-Barr virus (EBV) is a human tumor virus best known for its B cell-transforming capacity and association with lymphomas and carcinomas. Epidemiological studies have suggested that its infection, in addition, is necessary for the deve...