CD4+ T-Cell-Intrinsic IL-6 Is Critical for Th17 Differentiation and Dampened Responsiveness to CD8+ T Cell-Mediated Suppression
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This study investigates the role of T-cell-intrinsic IL-6 in Th17 differentiation and effector resistance. Using CRISPR-Cas9-mediated Il6 knockdown in primary human CD4+ T-cells, we demonstrate that T-cell-produced IL-6 is crucial for the optimal development o... ...
