Structure-Guided Engineering of TIGIT to Modulate Its Interaction With Nectin-4, a Tumour-Specific Antigen for the Development of Therapeutic Strategy [0.03%]
基于结构的TIGIT工程化调控其与肿瘤特异性抗原nectin-4相互作用以开发治疗策略
Namrata Ganguli,Sayantan Shaw,Sohini Sarkar et al.
Namrata Ganguli et al.
Nectin and nectin-like proteins are cell adhesion molecules belonging to the immunoglobulin superfamily that also play a crucial role in the process of immune modulation by interacting with immune receptors like TIGIT, DNAM-1, CD96 and PVRI...
Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Central Memory Th Cells in an α7 Nicotinic Acetylcholine Receptor-Dependent Manner [0.03%]
尼古丁通过依赖α7胆碱能受体的方式抑制人类记忆T辅助细胞亚群及其对中央记忆T辅助细胞的优先作用
Fatemeh Gholizadeh,Mehri Hajiaghayi,Niloufar Rahbari et al.
Fatemeh Gholizadeh et al.
Memory T helper (Th) cells sustain protective recall responses but can also drive chronic inflammation, necessitating precise regulation of their effector programs. Although Th cells produce acetylcholine (ACh) and express nicotinic acetylc...
Multi-Parameter Spectral Flow Cytometry Panel for Immune Phenotyping of Murine B and T Cell Responses [0.03%]
用于小鼠B细胞和T细胞反应免疫表型的多参数光谱流式细胞术面板
Kassandra Hoetzel,Hendrik Feuerstein,Julia Ludwig et al.
Kassandra Hoetzel et al.
To enable the analysis of B cell and T cell immune responses in mouse lymph nodes, spleen, and bone marrow, including different B cell and T cell subsets and their activation status, as well as the antigen-reactivity and isotype of B cells,...
Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903-induced Skin Inflammation [0.03%]
MC903诱导的皮肤炎症反应中朗格汉斯细胞表达胸腺基质淋巴细胞生成素及其受体复合物的动力学研究
Martín I González-Rodríguez,Tanja Salomaa,Carolina Cabalin et al.
Martín I González-Rodríguez et al.
Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclea...
Systemic Type I Interferon Blockade Mitigates Insulin Resistance in a Preclinical Model of Psoriasis [0.03%]
系统性I型干扰素阻断缓解银屑病动物模型中的胰岛素抵抗现象
Bishnu Prasad Sinha,Purbita Bandopadhyay,Md Asmaul Hoque et al.
Bishnu Prasad Sinha et al.
Psoriasis is a cutaneous autoimmune disease with worldwide prevalence. In situ activation of skin-infiltrating plasmacytoid dendritic cells (pDCs) leading to local induction of type I interferons (IFNs) is a crucial innate initiation event ...
Deletion of Lymphatic PD-L1 Protects Mice From Severe Autoimmune Encephalitis [0.03%]
淋巴管PD-L1缺失能够保护小鼠免受自身免疫性脑炎的侵害
Ziyuan Wang,Elèni Meuffels,Christian Ashworth et al.
Ziyuan Wang et al.
Lymphatic endothelial cells at the cribriform plate and in brain-draining cervical lymph nodes express PD-L1 during autoimmune encephalitis. Unexpectedly, deletion of lymphatic PD-L1 expression ameliorates disease symptoms and is associated...
A New Immunofluorescence Assay Allows the Sensitive Detection of Anti-Cytosolic 5'-Nucleotidase 1A Autoantibodies [0.03%]
一种新的免疫荧光检测方法能够敏感地检测抗胞质5'-核苷酸酶1A自身抗体
Fleur N Brinkman,Isa G A Verlangen,Filine Swets et al.
Fleur N Brinkman et al.
Anti-cN1A autoantibodies are helpful for diagnosing inclusion body myositis (IBM). We have developed an immunofluorescence assay based on the perinuclear accumulation of GFP-cN1A. The analysis of patient sera indicated that this assay shows...
Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice [0.03%]
新生儿中性粒细胞耗竭加重大肠杆菌感染新生小鼠的败血症病情
Julian Schwarz,Janine Hebel,Stefanie Dietz-Ziegler et al.
Julian Schwarz et al.
Neonates are particularly susceptible to infections because of a reduced ability to fight bacterial pathogens while simultaneously exhibiting enhanced inflammatory damage. Neonatal neutrophilic cells (NNC) are a heterogeneous population of ...
Irgm1 Restrains CD8+ T Cell Cytokine Production and Apoptosis via Cell-Extrinsic Regulation of Type I Interferon Signaling [0.03%]
IRGM1通过细胞外在调节I型干扰素信号抑制CD8⁺T细胞细胞因子的产生和凋亡
Caitlyn T Molloy,Yazan Alwarawrah,Jonathan A Cohen et al.
Caitlyn T Molloy et al.
Immunity-related GTPases (IRGs) are a family of proteins that maintain cellular homeostasis by promoting autophagy and mitophagy. Mutations in human IRGM and genetic deletion of mouse Irgm1 have been linked to increased severity of inflamma...
Selective Depletion of Autoreactive Plasma Cells as a Novel Strategy to Treat Acetylcholine Receptor Antibody-Positive Myasthenia Gravis [0.03%]
选择性耗竭自身反应性浆细胞治疗乙酰胆碱受体抗体阳性重症肌无力的新型策略
Laleh Khodadadi,Deborah Puppe,Dilara S Cirillo et al.
Laleh Khodadadi et al.
Myasthenia gravis (MG) is a chronic autoimmune disease mediated by autoantibodies targeting the neuromuscular junction and leading to muscle weakness. Although there are autoantibodies of different specificities, most MG patients have autoa...