Identifying Negative Biomarkers of CD4 Cytotoxic T Lymphocytes via Granzyme B Exclusion Analysis [0.03%]
通过颗粒酶B排除分析鉴定CD4细胞毒性T淋巴细胞的阴性生物标志物
Bingsu Wang,Ayibaota Bahabayi,Danyi Huang et al.
Bingsu Wang et al.
CD4 cytotoxic T lymphocytes (CTLs) are a distinct subset of CD4+ T cells that can mediate antigen-specific cytotoxicity. However, their specific surface markers have yet to be defined. In this study, we used gene-plasticity-based mutual exc...
A Unique Intraexonic Splicing Mechanism in the Immunoglobulin Domain of NKp30 Produces a Surface-Expressed Receptor With Altered Ligand Specificity [0.03%]
一种独特的嵌入外显子拼接机制在自然杀伤细胞受体NKp30的免疫球蛋白结构域产生具有改变配体特异性的表面表达受体
Elisabeth G Bjørnsen,Ellen Sofie Pete,Hanna Chan et al.
Elisabeth G Bjørnsen et al.
The activating receptor NKp30 is important in NK cell killing of cancer cells. Here, we demonstrated that a pair of splice signals in the Ig domain exon of human NKp30 is largely conserved among primates and placental mammals and produces a...
D von La Roche,I Naumann,E Szőcs et al.
D von La Roche et al.
Due to fundamental differences in B cell development between birds and mammals, knowledge of avian plasma cells (PCs) remains scarce, and PC-specific markers have been lacking. We isolated leukocytes from the Harderian gland (HG), a lacrima...
Managing Autofluorescence in Spectral Flow Cytometry for Macrophage Identification in the Liver [0.03%]
光谱流式细胞仪在肝脏巨噬细胞鉴定中管理自发荧光
Sabine Daemen,Tuneille I Adelaar,Panos Barlampas et al.
Sabine Daemen et al.
Autofluorescence (AF) in biological tissues arises from the natural emission of light by intra and extracellular molecules upon light absorption. Conventional flow cytometry cannot correct for cellular AF, leading to distorted signals and m...
Stable β2-Microglobulin-HLA Class I Association Reshapes the Antigenic Landscape and TCR Recognition of Cancer-Associated Epitopes [0.03%]
稳定的β2微球蛋白-人类白细胞抗原I类关联重塑了癌症相关表位的抗原景观和TCR识别能力
Ana Barajas Molina,Yehor Horokhovskyi,Nicole Acuti et al.
Ana Barajas Molina et al.
β2-Microglobulin (β2m) is essential for the stability and surface expression of human leukocyte antigen class I (HLA-I) molecules. While β2m's structural role is well established, its influence on the antigenic landscape remains incomple...
STING Activation in Dendritic Cells Enhances Antigen Presentation by Live Tumor Cells [0.03%]
树突细胞中活化STING可增强肿瘤细胞的提呈抗原能力
Adriana Loverre,Bakhos Jneid,Magali Genest et al.
Adriana Loverre et al.
The stimulator of interferon genes (STING) pathway is a key regulator of antitumor immunity. Activation of STING by the natural agonist 2'3'-cyclic GMP-AMP (cGAMP) induces type I interferon and promotes CD8+ T cell responses against tumors....
Vincent Heyer,Sandy Haidar Ahmad,Mira Haddad et al.
Vincent Heyer et al.
Hypoxia has been shown to shape the humoral immune response within germinal centers, where B cells diversify their receptors through somatic hypermutation (SHM) and class switch recombination (CSR). Both processes are initiated by activatio...
The RNA- and DNA-Binding Protein Y-Box Binding Protein 1 (YB-1) Regulates iNKT Cell Development [0.03%]
RNA和DNA结合蛋白Y盒结合蛋白1(YB-1)调节iNKT细胞发育
Silvia Schulze,Laura Knop,Nouria Jantz-Naeem et al.
Silvia Schulze et al.
Y-box binding protein 1 (YB-1) is a multifunctional RNA- and DNA-binding protein with broad regulatory functions in gene expression, particularly at the posttranscriptional level. Here, we demonstrate that conditional deletion of YB-1 at th...
Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site [0.03%]
结直肠癌腹膜转移灶中的岩藻糖转移酶介导的唾液酸化重塑抗肿瘤免疫微环境
Irene van der Haar Àvila,Kristiaan Lenos,Victor Lorrain et al.
Irene van der Haar Àvila et al.
Colorectal cancer (CRC) patients are frequently diagnosed with metastases to the peritoneal cavity. These patients have a dismal prognosis and only limited therapeutical benefits. Solid tumors, including CRC, often display elevated levels o...
Xiaoguang Li,Fedik Rahimov,Rui Wang et al.
Xiaoguang Li et al.
Genome-wide association studies implicate the PTPN2 gene locus (18p11.21) in risk for several autoimmune diseases, including inflammatory bowel disease. Through genetic fine mapping, we identified the single-nucleotide polymorphism rs802624...