Shifting From Systemic to Precision-Targeted Complement Therapies: Opportunities and Hurdles [0.03%]
从系统性补体疗法转向精准靶向补体疗法：机遇与挑战
Marco Mannes,Wioleta M Zelek,Leendert A Trouw
Marco Mannes
The landscape of complement therapeutics has significantly broadened in recent years; systemically acting stoichiometric inhibitors against complement proteins across almost the entire complement cascade are now available. However, despite ...
Methodological Insights Into T-Cell Activation: CD3/CD28 Versus PMA/Ionomycin Stimulation [0.03%]
T细胞活化的研究方法：CD3/CD28与PMA/Iono刺激体系的比较与联系
Nekruz Abdulhaqov,Lady Tatiana Albarracin Melo,Ines Meinert et al.
Nekruz Abdulhaqov et al.
PMA/ionomycin and CD3/CD28 stimulation induce fundamentally distinct signaling programs in primary human T cells. While CD3/CD28 stimulation activates both ERK and IL-2/STAT5 signaling pathways, PMA/ionomycin induces predominantly ERK-depen...
The Memory Inflation Response Against Spread-Defective CMV Requires Priming-Independent CD4+ T Cell Help [0.03%]
针对扩散缺陷型CMV的回忆性免疫反应依赖于不需要初始激活的CD4+T细胞的帮助
Jack Barton,Yeonsu Kim,Matthias T Warkotsch et al.
Jack Barton et al.
Memory inflation (MI) is a distinctive CD8+ T cell response to chronic cytomegalovirus (CMV) infection, characterized by non-contracting, functional populations that are predominantly effector differentiated. Harnessing such responses has r...
Marc Veldhoen,Cristina Ferreira
Marc Veldhoen
T cell exhaustion is now recognised as a structured, antigen-driven differentiation programme rather than a state of cellular fatigue. Under sustained antigen exposure, CD8+ T cells progress through distinct, hierarchically organised differ...
Mesenteric Adipose Tissue as a Modulator of Intestinal Inflammation: Mechanistic Insights and Model Systems in Crohn's Disease [0.03%]
肠系膜脂肪组织在肠道炎症中的调节作用：克罗恩病中的机制见解和模型系统
Toka Omar,Carl Weidinger,Britta Siegmund
Toka Omar
Inflammatory bowel disease, including Crohn's disease (CD) and ulcerative colitis, is becoming increasingly prevalent. Obesity, specifically visceral adiposity, has been identified as a significant risk factor for disease recurrence and com...
Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD [0.03%]
解码补体调节蛋白因子H及相关蛋白：补体系统失调与年龄相关性黄斑变性的联系
Jiaqi Tang,Nathalie Zgoda,Simon J Clark
Jiaqi Tang
Age-related macular degeneration (AMD) is the third most common form of blindness in the Western world, with a predicted 288 million individuals affected worldwide by the year 2040. Both genetic and biochemical evidence point toward complem...
Tuning the Affinity of Chimeric Antigen Receptors Enhances the Function of Human Engineered Regulatory T Cells [0.03%]
调优嵌合抗原受体的亲和力可增强工程调节性T细胞的功能
Ada Sera Kurt,Marwa Elgosbi,Elisavet Kodela et al.
Ada Sera Kurt et al.
Chimeric antigen receptors (CAR) incorporating single-chain variable fragments (scFv) exhibit much higher affinity for their cognate antigens than native T cell receptors (TCR). Reducing the affinity of the CAR has been shown to improve the...
Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions [0.03%]
小鼠肺驻留天然淋巴细胞异质性研究
Sandy Kroh,Anna Pascual-Reguant,Artür Manukyan et al.
Sandy Kroh et al.
As key regulators of mucosal immunity, innate lymphoid cells (ILCs) are involved in tissue homeostasis, inflammation, and repair. Studying ILCs within their native microenvironment remains challenging due to the low abundance of these tissu...
Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation [0.03%]
铁蛋白体外释放与树突状细胞内铁积累分离
Carrie Corkish,Simon O&#x;Shaughnessy,Claire Lin et al.
Carrie Corkish et al.
Plasmacytoid dendritic cells (pDCs) are specialized antiviral sentinels defined by rapid type I interferon (IFN‑I) production, yet their proteomic organization and metabolic requirements remain incompletely understood. We established the s...
Pro- and Anti-Inflammatory Macrophages Adjust UCP2 Protein Levels Based on Their Intrinsic Metabolism and Available Metabolites [0.03%]
促炎和抑炎巨噬细胞根据其固有的代谢和可用的代谢单位调整UCP2蛋白水平
Jila Nasirzade,Felix Sternberg,Andrea Vogel et al.
Jila Nasirzade et al.
The immune and metabolic responses of macrophages are closely linked. Mitochondrial uncoupling protein 2 (UCP2), proposed to facilitate metabolite transport, is involved in regulating inflammation and glucose metabolism in macrophages. Howe...