Methodological Insights Into T-Cell Activation: CD3/CD28 Versus PMA/Ionomycin Stimulation
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PMA/ionomycin and CD3/CD28 stimulation induce fundamentally distinct signaling programs in primary human T cells. While CD3/CD28 stimulation activates both ERK and IL-2/STAT5 signaling pathways, PMA/ionomycin induces predominantly ERK-dependent proliferation d... ...
