Complement Gene Variants Define the Conformational Dynamics of C3 Convertase [0.03%]
补体基因变异定义了C3转化酶的构象动力学
Héctor Martín Merinero,Seth J Welsh,Zhen Xu et al.
Héctor Martín Merinero et al.
Current understanding of the structure, function, and molecular dynamics of the alternative pathway C3-convertase has been shaped by the clinical impact of genetic variants in complement genes. Characterizing the functional impact of differ...
High-Salt Diet Links Gut Microbiota, Intestinal Barrier Function, and Macrophage Responses [0.03%]
高盐饮食连接肠道微生物群、肠屏障功能和巨噬细胞反应
Akram Abdulkadyrov,Marie-Louise Diefenbach-Wilke,Elvira Mass et al.
Akram Abdulkadyrov et al.
The Global North is increasingly exposed to a Western diet characterized by high fat, sugar, and salt content. Excess dietary salt has been linked to cardiovascular disease and hypertension and can accumulate in multiple tissues, exerting l...
Pam3CSK4 As a Second Hit in NLRP3-Dependent Activation of Monocytes Primed With Antiphospholipid Antibodies [0.03%]
抗磷脂抗体预处理的单核细胞中 Pam3CSK4 作为NLRP3依赖的激活的二次打击
Anush Martirosyan,Eva Kriegova,Jana Ulehlova et al.
Anush Martirosyan et al.
Antiphospholipid antibodies (aPL) are drivers of inflammation and thrombosis in antiphospholipid syndrome (APS). However, the molecular mechanisms underlying infection-induced exacerbation of APS remain incompletely understood. To identify ...
Fast Generation of F(Ab')2 Fragments From Human IgG Using Fc-Fused IgG-Degrading Enzyme [0.03%]
利用Fc融合型IgG降解酶快速生成人IgG的F(Ab')2片段
Emna Hannachi,Robin V Lacombe,Amélia Trecco et al.
Emna Hannachi et al.
Removal of Fc-fragments from human IgG or Fc-fused proteins. (1) IgG or Fc-fusion proteins are incubated with IdeS-Fc; (2) Fc fragments are retained using protein G agarose beads; and (3) the F(ab')2 fragments or Fc-free proteins are collec...
Nicoline H M Den Hollander,Chelsea Gootjes,Maurits G Staal et al.
Nicoline H M Den Hollander et al.
Type 1 diabetes (T1D) results from T cell-mediated destruction of insulin-producing pancreatic beta-cells. Recently, the immune-provoking role of stress-related neoantigens has become evident. Neoantigens unlikely contribute to central tole...
Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection? [0.03%]
补体抑制的临床应用：我们为预防患者感染做了足够的工作了吗？
Serena Bettoni,Ebba Qviberg,Edward Chaloner et al.
Serena Bettoni et al.
Discovered in the late 19th century as a heat-sensitive plasma factor called "alexin", complement was first identified for its ability to work with antibodies to destroy microorganisms. Over the past two centuries, research advances have fi...
CRISPR/Cas9-Mediated Gene Knockout Reveals a Nonredundant Role for p16INK4A in Controlling TCR-Dependent and Independent CD8 T Cell Expansion [0.03%]
利用CRISPR/Cas9基因敲除技术揭示p16INK4A在控制TCR依赖和非依赖CD8T细胞增殖中的不可或缺的作用
Silvia Fiori,Cecilia Adragna,Emilia Malvicini et al.
Silvia Fiori et al.
The possibility of enhancing T cell function by deleting specific genes represents a long-sought goal in preclinical studies and ultimately for clinical applications. Using CRISPR/Cas9 genome editing, we report that, in human cytotoxic CD8 ...
Induction of Humoral and Cellular Immunity After SARS-CoV-2 JN.1 Vaccination in Individuals With and Without Prior Infection [0.03%]
既往感染个体和未感染个体在接种SARS-CoV-2 JN.1疫苗后的体液免疫和细胞免疫诱导作用
Caroline Diener,Rebecca Urschel,Saskia Bronder et al.
Caroline Diener et al.
The continuous evolution of SARS-CoV-2 raises concerns about immune escape from preexisting immunity. The monovalent JN.1adapted mRNA vaccine was developed to better match circulating variants, yet data on its ability to induce and broaden ...
Complement in Traumatic Brain Injury: Linking Acute Injury to Chronic Neurodegeneration [0.03%]
补体在创伤性脑损伤中的作用：急性损伤与慢性神经退行性变之间的联系
Ariana Chacon,Roy Raheb Khelo,Layth J M Saada et al.
Ariana Chacon et al.
Traumatic brain injury (TBI) is increasingly recognized not only as an acute mechanical insult but as a trigger of sustained neuroimmune activation that contributes to chronic neurodegeneration. The complement system has emerged as a centra...