Ccl21a, Rather Than Ccl21b, is Essential for Thymocyte Migration in Mouse [0.03%]
CCL21A而不是CCL21B是小鼠胸腺中胸腺细胞迁移所必需的
Izumi Ohigashi,Hitomi Kyuma,Eri Otsu et al.
Izumi Ohigashi et al.
Self-tolerance in T cells is a vital self-defense strategy for mammals to specifically respond to invading pathogens. During T cell development in the thymus, thymocytes migrate from the cortex to the medulla to sequentially acquire non-sel...
CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein-Coupled Receptors [0.03%]
抗体验证和免疫系统G蛋白偶联受体的表达谱分析及CD分子命名（2025）
Javier Fernández-Calles,Daniela Kužílková,Fanny Hedin et al.
Javier Fernández-Calles et al.
Monoclonal antibodies (mAbs) targeting cell-surface molecules are pivotal in biomedical research, diagnostic applications, and biotechnology. Over the past four decades, the CD nomenclature system, established by the Human Leukocyte Differe...
Klaus Heger,Ali Masjedi,Assa Yeroslaviz et al.
Klaus Heger et al.
Mast cells are evolutionarily ancient immune cells located at strategic entry points for pathogens and allergens. Allergen exposure activates signal transduction pathways resembling those downstream of antigen receptors in T and B lymphocyt...
Optimising Recovery of Hepatic Regulatory T Cells: A Practical Guide Using ARTC2 Blockade [0.03%]
优化肝调节T细胞回收的实用指南：使用ARTC2阻断法
Caitlin Abbott,Violette Mouro,Chiara Perucchini et al.
Caitlin Abbott et al.
This is an update to the Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition), Chapter 3: 12C, by Cossarizza et al. Administration of anti-ARTC2 nanobody(S+16a) prevents cell death during tissue...
Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies [0.03%]
过敏和过敏性休克复杂小鼠模型的见解：IgE和肥大细胞在人类治疗中的中心作用及其展望
Yuka Nagata,Ryo Suzuki
Yuka Nagata
Immunoglobulin E (IgE)-mediated immediate hypersensitivity reactions underlie most allergic responses and are characterized by rapid mast cell (MC) activation and the subsequent release of mediators. These processes have been studied in rod...
FcµR and IgM-Mediated Complement Activation Cooperate to Enhance Humoral Immunity [0.03%]
FcμR和IgM介导的补体激活相互协作以增强体液免疫反应
Zichao Wen,Lulu Dong,Jun Liu et al.
Zichao Wen et al.
Secretory IgM plays a pivotal role in promoting robust antigen-specific IgG responses, yet the mechanisms underlying its immune-enhancing effects remain incompletely understood. IgM functions through two distinct pathways: engagement of the...
Characterization of the SARS-CoV-2-Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID-19 Protection [0.03%]
风湿性关节炎患者接种新型冠状病毒疫苗后SARS-CoV-2特异性T细胞免疫反应的特征分析
Jaeyoon Song,Ricardo da Silva Antunes,Mehrnaz Agili Seyede et al.
Jaeyoon Song et al.
The efficacy of mRNA-based vaccines to prevent COVID-19 in autoimmune patients is controversial due to immunosuppressive therapies. Here, we characterized the T cell responses to SARS-CoV-2 in rheumatoid arthritis (RA) subjects, who receive...
Augmented MHC Class I on Professional Antigen-Presenting Cells and Enhanced Cytokine Production by CD8+ T Cells in Type 2 Diabetes Mellitus [0.03%]
2型糖尿病中专职抗原递呈细胞上MHC-I类分子上调及CD8+t细胞产生细胞因子增强
Shan Liu,Tharushika Jayasinghe,Daria Kamińska et al.
Shan Liu et al.
Effective antigen presentation by major histocompatibility complex (MHC) molecules to T cells is crucial for adaptive immunity. In type 2 diabetes mellitus (T2DM), metabolic dysregulation and chronic inflammation may impair these processes....
Staphylococcal Enterotoxin A Shapes Monocyte Transcription and Macrophage Polarization: Implications for Immune Responses in Infection and Inflammation [0.03%]
金黄色葡萄球菌肠毒素A重塑单核细胞转录及巨噬细胞极化：感染和炎症中免疫反应的含义
Claudia Arasa,Khaleda Rahman Qazi,David Brodin et al.
Claudia Arasa et al.
Staphylococcal enterotoxins (SE) crosslink the MHC-II on antigen-presenting cells (APC) with the T-cell receptor, inducing a polyclonal T-cell response. Although APCs are the initial targets of SE and are critical in shaping subsequent T-ce...
Isabell Naumann,Edward S Ricemeyer,Daniel Elleder et al.
Isabell Naumann et al.
Regulatory T cells (Tregs), defined by the lineage-specific transcription factor FoxP3, are crucial for immune regulation and have been studied extensively in mammals. However, avian Tregs remain poorly characterized, leaving gaps in our un...