A Molecular Staircase Built from Hydrazide-Linked Pyridines as an Artificial Proton Channel [0.03%]
一个由肼连接的吡啶构建的分子阶梯作为人工质子通道
Jianhe Xu,Yanbin Chen,Jianru Wang et al.
Jianhe Xu et al.
Artificial proton channels exhibiting high selectivity remain largely unexplored, with only two such systems recently reported. Inspired by the DNA duplex's iconic helical structure, we present here a novel strategy for designing a molecula...
Small Molecule Promoters of Endogenous Lipid Droplet Accumulation Drive Lysophagy [0.03%]
促进内源性中性脂滴积累的小分子可诱发lysophagy现象
Sai Kumari Vechalapu,Santhosh Duraisamy,Sathyapriya Senthil et al.
Sai Kumari Vechalapu et al.
Lipid droplets (LDs) are central in regulating metabolism in stress-induced conditions, including one triggered by nutrient deprivation. Genetic manipulation of the lipid metabolic network or supplementation of a high-fat diet/oleic acid (O...
Fan Lin,Ting-Ting Song,Yan Liu et al.
Fan Lin et al.
Naturally occurring dimeric products have attracted considerable attention from both chemists and pharmacologists. The construction of pseudo-dimers often requires elaborate synthetic effort with low efficiency. Dearomatization reactions re...
Chemoenzymatic Synthesis and Protein Engineering Enable Efficient, Scalable Production of Teleocidin Derivatives [0.03%]
化学酶法合成和蛋白质工程实现Teleocidin衍生物的高效、规模化生产
Shuo Zheng,Zixuan Yang,Xiang Long et al.
Shuo Zheng et al.
Monoterpenoid indole alkaloids (MIAs), a class of bioactive natural products, are highly valued in drug development for their unique pharmacological activities. Teleocidins, known for activating protein kinase C (PKC), are particularly prom...
Directional Depolymerization of Poly(ε-caprolactone) with High Monomer Selectivity [0.03%]
高单体选择性合成聚-ε-己内酯的定向降解反应
Rulin Yang,Wei Wei,Guangqiang Xu et al.
Rulin Yang et al.
Chemical recycling to monomer (CRM) is the most attractive method for achieving the closed-loop usage of polymers, in which polymers are recycled back to their starting monomers and then used to produce new polymers without loss of the virg...
Spillover-Mediated H* Redistribution Promotes Electrocatalytic Acetonitrile Hydrogenation in PEM Reactors [0.03%]
溢出效应介导的H*重新分布促进质子交换膜反应器中的电催化氢气加成氮化反应
Shan Huang,Bingying Han,Ye Liu et al.
Shan Huang et al.
Electrocatalytic acetonitrile hydrogenation (EAH) provides a sustainable route for ethylamine synthesis, yet suffers from low productivity, competitive hydrogen evolution reaction (HER), and high energy consumption due to suboptimal catalys...
Preston C Gourville,Jade A Bing,Rashanique D Quarels et al.
Preston C Gourville et al.
The preparation of peptidic molecules is a mainstay of synthesis, creating new tools that advance chemical biology, catalysis, and drug discovery. Despite the wide adoption of methods for amide synthesis based on electrophilic acyl transfer...
Synergistic Light-Ultrasound-Driven Hydrogen Production by Hydrogen Iodide Decomposition Over Dual-Molecular Ferroelectric Heterostructure [0.03%]
用于分解氢碘酸的双分子铁电异质结构的协同光超声波驱动制氢技术
Zi Ning Zhou,Qing Dian Chong,Ya Wen Yang et al.
Zi Ning Zhou et al.
Emerging catalytic systems for hydrogen production via solar and mechanical energy conversion often face critical challenges, including band mismatch, interfacial charge recombination, and insufficient charge migration driving forces. To ad...
Controlled Crystallization Kinetics via Conjugated Organic Spacers Enables Ordered Epitaxial Growth of Two-Step Deposited Tin-based Perovskite Solar Cells [0.03%]
通过共轭有机间隔物控制结晶动力学可使两步沉积的锡基钙钛矿太阳能电池实现有序外延生长
Hongbo Zhou,Huan Rao,Yu Jin et al.
Hongbo Zhou et al.
Tin-based perovskite films typically exhibit random crystal orientations, with significant accumulation of defects acting as charge recombination centers, which severely limit device performance. Furthermore, the disordered two-dimensional ...
Heterointerface Anchored Ir with Localized Strong Orbital Coupling for Durable Proton Exchange Membrane Water Electrolysis [0.03%]
用于耐久型质子交换膜电解水的局域强轨道耦合异界面锚定铱催化剂
Jing Ni,Zhaoping Shi,Jingsen Bai et al.
Jing Ni et al.
The imperative to minimize iridium usage in proton exchange membrane water electrolysis (PEMWE) process presents a pivotal challenge for hydrogen economy deployment, while inherent destabilization of iridium (Ir) active sites under corrosiv...