Iron-Catalyzed Asymmetric [4+2]/Cheletropic Retro-[4+1] Cycloadditions of Thiophene S,S-Dioxides with 3-Substituted Indoles [0.03%]
铁催化硫化物S,S-二氧化物与3-取代吲哚[4+2]/CHELETROTROPIC RETRO-[4+1]环加成反应的不对称合成
Shi-Xiong Feng,Qi-Tao Lu,Yang Lu et al.
Shi-Xiong Feng et al.
The Diels-Alder/cheletropic retro-[4+1] cycloadditions of thiophene S,S-dioxides are a prominent method for synthesizing unsaturated six-membered carbocycles. However, to the best of our knowledge, catalytic asymmetric variations of these r...
Optoregulated mRNA Delivery Controls Pleiotropic Immune Signaling for Tumor-Targeted Therapy [0.03%]
光调控信使核糖核酸递送控制多效免疫信号通路用于肿瘤靶向治疗
Pengwen Chen,Guanghao Hu,Yuki Nakashima et al.
Pengwen Chen et al.
Spatiotemporal control of protein expression remains a critical challenge in messenger RNA (mRNA) therapeutics, particularly for tumor-targeted therapy. Here, we introduce a Light-Induced Transfection System (LITS) leveraging photosensitizi...
TASK2-Inspired pH-Gating Polymeric Nanochannels with Multiple Interconvertible Permeability States by Synergistic Regulation of Conformation and Charge [0.03%]
任务2：通过协同调节构象和电荷调控的多态可转换性pH门控聚合物纳米通道
Shengyang Zhou,Fengyu Ai,Zihe Song et al.
Shengyang Zhou et al.
Biological ion channels can regulate finely the ion transmembrane permeation, with superhigh ion selectivity and on-off ion flux in response to external stimuli, for signal transduction and energy conversion. However, fabricating smart arti...
Quasi-Homogeneous Photocatalytic C─H Functionalization Enabled by Donor-Acceptor Microporous Polymer Aerogels Featuring Ultralong-Lived and Long-Range Excitons [0.03%]
受体给体型微孔聚合物气凝胶促进的长寿命长迁移激子催化自由基C-H功能化反应
Bin Chen,Bo Li,Yan Su et al.
Bin Chen et al.
Simultaneous promotion of charge and mass transportation between catalytic centers and reactants is crucial for photocatalysis but remains a substantial challenge on account of the widespread use of homogeneous or heterogeneous photocatalys...
d-p Orbital Hybridization of Ternary Transition Metal Toward High-Performance Proton Storage [0.03%]
三元过渡金属d-p轨道杂化促进高性能质子存储性能
Wei Tu,Ke Mao,Ying Huang et al.
Wei Tu et al.
Electrochemical proton storage offers grid-scale energy storage system with long lifespan, great safety, and eco-friendliness. However, preparing proton storage materials with balanced conductivity, activity, and stability remains challengi...
Rational Design of an Organotellurium Chalcogen Bonding Catalyst for Azetidine Activation [0.03%]
用于氮杂环丙烷活化的有机碲元素硫醇键催化剂的理性设计
Fei Jiang,Lian-Zheng Zuo,Hao-Wen Zhao et al.
Fei Jiang et al.
The application of chalcogen bonding catalysis has been largely confined to benchmark reactions due to the limited structural diversity and activating ability of the catalysts, especially those derived from tellurium. Herein, we present a g...
Hδ --Hδ + Comproportionation Enables Stable Li-N-H-F Solid Electrolyte [0.03%]
Hδ-和Hδ+共比例化实现稳定的锂-氮-氢-氟固态电解质
Yuepeng Pang,Chao Wei,Xiangyang Ye et al.
Yuepeng Pang et al.
Nitride family compounds are among the earliest explored materials for solid electrolytes (SEs). The main challenge lies in effectively enhancing their electrochemical stability without compromising their excellent Li-ion conductivity and L...
Origin and Suppression of Intragranular Cracks for Long-Cycling High-Ni Co-Free Cathodes [0.03%]
长循环高镍无钴正极材料中晶内裂纹的产生及抑制机制研究
Zhiming Xiao,Xinyou He,Fenghua Zheng et al.
Zhiming Xiao et al.
Intragranular cracks have been identified as a direct reflection of failure in high-energy-density cathodes, especially for high-Ni Co-free cathodes with severe electrochemical-mechanical degradation. Here we show that antiphase boundaries ...
Protein-Protein Complex Stability Controls Substrate Scope in a β-Ketoacyl-ACP Reductase Specific for Medium Chains [0.03%]
蛋白质-蛋白质复合体稳定性控制β-酮酰基-ACP还原酶的底物范围（仅限中链）
Samuel J Andrzejewski,Anika J Friedman,Kathryn Mains et al.
Samuel J Andrzejewski et al.
Assembly-line enzymes carry out multistep synthesis of important metabolites by using acyl carrier proteins (ACPs) to shuttle intermediates along defined sequences of active sites. Despite longstanding interest in reprogramming these system...