Impact of Glycoclustering on Stiffening of MUC5AC Peptides Revealed by High-Efficiency Synthesis [0.03%]
高效合成揭示甘露糖聚类对MUC5AC肽刚性的影响
Arseniy Galashov,Elisabetta di Gregorio,Polina Ponomareva et al.
Arseniy Galashov et al.
Clustered O-glycosylation of long tandem repeat regions is the hallmark of secreted mucins such as MUC5AC. Glycosylation is thought to play a key role in rigidifying the peptide backbone. The synthesis of peptides containing extended O-glyc...
Partitioning COF Membrane Channels into Ultramicroporous and π-Electron-Rich Compartments for Multicomponent Ion Separations [0.03%]
通过划分COF膜通道实现多组分离子分离中的超微孔隙和π电子富集区的分离
Meidi Wang,Zhuo-Hao Wu,Guan-Zheng Zhou et al.
Meidi Wang et al.
Covalent organic frameworks (COFs) build a versatile platform for constructing separation membranes, affording them disruptive candidates for nanoscale molecule/ion sieving. However, the reported aperture of COFs mainly concentrates on 0.8-...
From Light to Cure: Precision Phototherapies for Antibiotic-Refractory Biofilm Infections [0.03%]
从光照到治疗：抗生素耐药生物膜感染的精准光疗
Qihang Ding,Yuxin Xie,Kexin Xiong et al.
Qihang Ding et al.
Bacterial biofilms serve as formidable barriers in antimicrobial therapy and are central to the emergence and propagation of antimicrobial resistance. Their compact extracellular polymeric matrix, metabolic heterogeneity, and quorum-sensing...
Breaking the Linear Scaling Relations for the Oxygen Reduction Reaction with a Dual-Atom Catalyst Composed of a MnFe-Porphyrrole Aerogel [0.03%]
由锰铁双原子组成的卟啉气凝胶催化剂打破氧还原反应的线性标度关系
Eliana Lebowitz,Prasenjit Das,Łukasz Kielesiński et al.
Eliana Lebowitz et al.
Bimetallic catalysts offer enhanced catalytic performance through synergistic interactions between the two metals, allowing them to break the linear scaling relations and reach high electrocatalytic activity. This study presents bimetallic ...
Multidentate Macrocyclic Salphen-Based 2D Conjugated Metal-Organic Framework [0.03%]
基于多齿大环螯合Salphen的二维共价金属有机框架结构
Pei Chen,Mingxuan Liu,Ruofan Li et al.
Pei Chen et al.
Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) represent an emerging class of crystalline porous materials with promising electrochemical applications. The design of novel organic ligands for constructing 2D c-MOFs remains ...
Atomically Dispersed Rare Earth-Confined High-Entropy Alloy Nanocrystals for Efficient Ammonia Electrosynthesis [0.03%]
原子分散的稀土受限高熵合金纳米晶体高效电合成氨研究
Yong Jiang,Hao Fu,Ziyun Zhong et al.
Yong Jiang et al.
Rare earth (RE) elements with unique lanthanide contraction and electron configuration are promising for many important studies. Alloying RE with typical 3d/5d transition metals generates new or improved properties due to enhanced orbital c...
Catalytic Strategies for Stereoselective Carbohydrate Synthesis: Emerging Concepts for Accessing Challenging Glycosides [0.03%]
立体选择性糖合成的催化策略——获取挑战性的糖苷的新兴概念
Charles C J Loh
Charles C J Loh
The development of innovative catalytic strategies for stereoselective carbohydrate synthesis is rapidly emerging as a theme of general synthetic interest. This research frontier is fuelled by current realization that anomeric and site-sele...
Chloride-Bridged Compact Interfacial Shielding for Practical Seawater Zinc Batteries [0.03%]
用于实际海水锌电池的氯桥接紧缩界面屏蔽
Wenjie Fan,Huicai Wang,Xingjie Wang et al.
Wenjie Fan et al.
Substituting natural seawater (NS) for deionized water significantly reduces the electrolyte manufacturing cost of aqueous zinc (Zn) ion batteries, but it also poses severe corrosion challenges to the Zn metal anode, given the presence of t...
Tan Zhang,Zhikai Che,Yuru Song et al.
Tan Zhang et al.
The electrocatalytic nitrogen reduction reaction (NRR) offers a sustainable pathway for ambient-condition ammonia synthesis, yet its efficiency is fundamentally limited by the low N2 concentration in aqueous systems and the competing strong...
Fully-Functionalized Natural Product Probes to Expand the Chemical Tractability of the Human Proteome [0.03%]
全方位功能化的天然产物探针可扩展人类蛋白质组的化学可修饰性
Christian M Chaheine,Junchen Tang,Louis P Conway et al.
Christian M Chaheine et al.
Photoaffinity (PA)-based chemoproteomic methods have emerged as a powerful means for proteome-wide mapping of ligandable proteins directly in cells, as well as the concatenated discovery of small molecule chemical probes. However, due to th...