Pericarpium Trichosanthis Inhibits TGF-β1-Smad3 Pathway-Induced Cardiac Fibrosis in Heart Failure Rats via Upregulation of microRNA-29b [0.03%]
瓜蒌皮通过上调微小RNA-29b抑制转化生长因子-β1-Smad3信号通路诱导的心力衰竭大鼠心脏纤维化作用研究
Yue He,Meng-Shi Dai,Li-Yu Tao et al.
Yue He et al.
Cardiac dysfunction and adverse consequences induced by cardiac fibrosis have been well documented. However, the cardiac fibrosis pathway in chronic heart failure (CHF) remains unclear, and it is therefore necessary to conduct further resea...
Interaction Between YTH Domain-Containing Family Protein 2 and SET Domain-Containing Lysine Methyltransferase 7 Suppresses Autophagy in Osteoarthritis Chondrocytes, Exacerbating Cartilage Damage [0.03%]
YTH域结合家族蛋白2与SET结构域赖氨酸甲基转移酶7的相互作用通过抑制骨关节炎软骨细胞自噬而加重软骨损伤
Lexiang Li,Jun Zhu,Yi Chen et al.
Lexiang Li et al.
Background and objective: Osteoarthritis (OA) is characterized by progressive cartilage degeneration mediated by various molecular pathways, including inflammatory and autophagic processes. SET domain-containing lysine me...
Silencing N29 Regulated miR-193b-5p/TGFBR2 Axis to Mitigate the Progression of Cardiac Hypertrophy [0.03%]
沉默N29调控的miR-193b-5p/TGFBR2轴以缓解心脏肥厚进展
Hao Wu,Xinshuang Wang,Jing Yu et al.
Hao Wu et al.
The study aimed to analyze differentially expressed lncRNAs in a model of cardiac hypertrophy, specially focusing on the molecular mechanisms of lncRNA NONMMUT023529 (lncRNA N29) in myocardial hypertrophy. Based on gene microarray results, ...
YAP1 Overexpression Enhances the Aerobic Glycolysis Process via Suppression of EGLN2 in Pancreatic Ductal Adenocarcinoma [0.03%]
YAP1过表达通过抑制EGLN2增强胰腺导管腺癌的糖酵解过程
Pengfei Hu,Ruohan Dou,Zihao Qi et al.
Pengfei Hu et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases and has remarkably high mortality rates. In recent years, altered metabolism has been shown to contribute to the maintenance of pa...
Integrative Analysis Identifies NSUN2 as an Essential Coordinator for Glioma Malignancy and Glucose Metabolism [0.03%]
整合分析鉴定出NSUN2是胶质瘤恶性程度和糖代谢的关键调节因子
Yuze He,Yunbo Yuan,Linzi Ji et al.
Yuze He et al.
Background: Glioma, particularly glioblastoma, is the most common and aggressive primary brain tumor, with poor prognosis due to its metabolic heterogeneity. NSUN2, an m5C RNA methyltransferase and direct glucose sensor, ...
Christian Geils,Katie L Kathrein
Christian Geils
Immunotherapy describes a class of therapies in which the immune system is manipulated for therapeutic benefit. These treatments include immune checkpoint inhibitors, adoptive cell therapy, and vaccines. For many hematological malignancies,...
WES and Transcriptome Analysis Identifies FN1 as a Candidate Gene for Anterior Segment Dysgenesis [0.03%]
WES和转录组分析鉴定出FN1是前段发育不良的候选基因
Qinghong Lin,Xuejun Wang,Xiaosong Han et al.
Qinghong Lin et al.
Background: Anterior segment dysgenesis (ASD) disorders are phenotypically diverse and have multiple associated genes. This study reports on a Chinese family of three generations with ASD disorders and identifies several ...
Integrative analyses of genetic mechanisms responsible for bone-fat imbalance in osteoporosis [0.03%]
整合分析骨质疏松症骨骼-脂肪失衡的遗传机制
Zheng Zhang,Zhengbo Tao,Yuhe Zhang et al.
Zheng Zhang et al.
Osteoporosis manifests through adipocyte accrual and osteoblast diminution within bone marrow. However, the precise mechanisms driving the shift from osteogenesis to adipogenesis in bone marrow mesenchymal stem cells (BMSCs) remain largely ...
ANGPTL4-A protein involved in glucose metabolism, lipid metabolism, and tumor development [0.03%]
ANGPTL4：参与葡萄糖代谢、脂质代谢和肿瘤发生的相关蛋白
Zhilong Xu,Gening Jiang
Zhilong Xu
Since ANGPTL4 was discovered to be involved in lipid metabolism in 2000 for the first time, Angptl4 has attracted the attention of researchers. With the further research, it was found that angptl4 was also involved in many biological activi...
The suppression of OTUD7B by miR-491-5p enhances the ubiquitination of VEGFA to suppress vascular mimicry in non-small cell lung cancer [0.03%]
miR-491-5p通过抑制OTUD7B促进VEGFA泛素化以抑制非小细胞肺癌血管模似作用
Xiaofei Chen,Lijun He,Hai Zhong et al.
Xiaofei Chen et al.
Background: Non-small cell lung cancer (NSCLC) is the main type of lung cancer with high morbidity and mortality. Vascular mimicry (VM), a distinct microcirculation model in tumors that differs from classical angiogenesis...