DSCC1 as a Novel Biomarker in Hepatocellular Carcinoma: Diagnostic Potential, Prognostic Impact, Correlation With Key Pathways, and Association With the Immune Landscape [0.03%]
DSCC1作为肝细胞癌新型生物标志物的诊断潜能、预后影响、与关键通路的相关性及其免疫图谱关联性研究
Abdul Jamil Khan,Shad Man,Shahid Ullah Khan
Abdul Jamil Khan
Background: DSCC1, a key subunit of the alternative RFC complex, is essential for DNA replication and genome stability. While its role in cancers like breast cancer is documented, its function in LIHC remains largely unex...
DSCC1 as a Novel Biomarker in Hepatocellular Carcinoma: Diagnostic Potential, Prognostic Impact, Correlation With Key Pathways, and Association With the Immune Landscape [0.03%]
DSCC1作为肝细胞癌新型生物标志物的诊断潜能、预后影响、与关键通路的相关性及其免疫图谱关联性研究
Abdul Jamil Khan,Shad Man,Shahid Ullah Khan
Abdul Jamil Khan
Background: DSCC1, a key subunit of the alternative RFC complex, is essential for DNA replication and genome stability. While its role in cancers like breast cancer is documented, its function in LIHC remains largely unex...
Anti-Glutamic Acid Decarboxylase 65 (GAD65) Antibodies and Neurological Syndromes [0.03%]
抗谷氨酸脱羧酶-65自身抗体与神经系统综合征的关系
Omid Mohammadzadeh,Nafise Fahimzadeh,Fateme Elhami et al.
Omid Mohammadzadeh et al.
Various neurological disorders have been linked to the presence of serum antibodies targeting glutamic acid decarboxylase (GAD), a key enzyme in the production of γ-aminobutyric acid (GABA). Associated conditions include stiff-person syndr...
Melike Aliciaslan,Ezgi Erbasan,Fulya Erendor et al.
Melike Aliciaslan et al.
Prime editing (PE) represents a significant advancement in genome editing, offering high precision for diverse genetic modifications without inducing double-strand breaks or requiring exogenous donor DNA templates. This "search-and-replace"...
Tele-Genetic Versus Onsite Counseling for APOE Disclosure: A 6-Month Study of Empowerment, Psychological Distress, and Behavioral Outcomes in Cognitively Diverse Individuals [0.03%]
APOE基因检测远程遗传咨询与现场咨询的效果对比：一项关于认知功能各异个体的赋能、心理困扰及行为结果的6个月研究
Marina Makri,Ioanna Antigoni Angelidou,Despoina Moraitou et al.
Marina Makri et al.
Background: With the increasing demand for clinical genetic services and the lack of clinical geneticists, tele-genetics is utilized in clinical genetics to improve cost efficiency and equitable access to health services....
Randomized Controlled Trial
The journal of gene medicine. 2025 Oct;27(10):e70041. DOI:10.1002/jgm.70041 2025
Exploring Potential Hub Genes and Molecular Mechanisms Linking Cardia Carcinoma With Sjögren's Syndrome Based on Comprehensive Bioinformatics Analysis and Machine Learning [0.03%]
基于全面生物信息学分析和机器学习链接胃癌与舍格伦综合征的潜在枢纽基因和分子机制的研究探索
Meng Qian,Ying Chen,Zhenxiang Wang et al.
Meng Qian et al.
Background: Cardia carcinoma (CC) is a highly heterogeneous cancer with an increasing incidence worldwide. Gastroesophageal reflux disease has been identified as a risk factor for CC, and patients with Sjögren's syndrome...
Multi-Omics Integrated Analysis of the Protective Effect of Tertiary Lymphoid Structures and Associated Key Regulatory Genes in Human Gallbladder Cancer [0.03%]
人类胆囊癌中三级淋巴组织的保护作用及其相关关键调控基因的多组学整合分析
Xiaolong Chen,Yimin Nong,Ming Zhang et al.
Xiaolong Chen et al.
Tertiary lymphoid structures (TLSs) are lymphoid structures found in non-lymphoid tissues, which have been involved in the pathogenesis of multiple chronic diseases including tumors. TLSs are associated with better prognosis and response to...
Exploring the Protein-Metabolite Interplay to Discover Novel Drug Targets for Alzheimer's Disease [0.03%]
探索蛋白质-代谢物相互作用以发现治疗阿尔茨海默病的新药物靶点
Kang-Fu Yin,Xiao-Jing Gu,Zheng Jiang et al.
Kang-Fu Yin et al.
Background: The protein-metabolite interactions play a pivotal role in the pathogenesis of Alzheimer's disease (AD); however, the causal significance of these interactions in AD pathogenesis remains elusive. ...
Marine-Derived Enteromorpha prolifera Polysaccharides Suppress Castration-Resistant Prostate Cancer via Akt1 Inhibition [0.03%]
海洋来源的Enteromorpha prolifera多糖通过抑制Akt1来抑制去势抵抗性前列腺癌
Pingfa Lin,Na Yao,Tingting Lin et al.
Pingfa Lin et al.
Prostate cancer remains a leading cause of cancer-related mortality, with castration-resistant and metastatic forms posing significant therapeutic challenges. Marine-derived polysaccharides from Enteromorpha prolifera (EP) have emerged as p...
Mechanism of Tourette Syndrome Induced by ABGA-Mediated CaMKII-TH Pathway [0.03%]
ABGA介导的CaMKII-TH通路诱导抽动症的机制研究
Xinnan Wu,Juanjuan Hao,Keyu Jiang et al.
Xinnan Wu et al.
Background: In this study, we intend to investigate the mechanism by which anti-basal ganglia antibodies (ABGA) modulate dopamine release through the CaMKII-TH pathway, which leads to the onset of Tourette syndrome (TS). ...