Chronic Granulomatous Disease: Clinical and Molecular Characterization of Brazilian Patients [0.03%]
巴西慢性肉芽肿病患者的临床和分子特征分析
Leonardo Martinello da Rosa,Martha Braun da Rosa,Mariana de Sampaio Leite Jobim Wilson et al.
Leonardo Martinello da Rosa et al.
Chronic granulomatous disease (CGD) is a rare inborn error of immunity caused by defects in components of the NADPH oxidase that impair the elimination of infectious microorganisms. Individuals affected by CGD become more susceptible to rec...
Single-Cell RNA Sequencing and Network Pharmacology Reveal the Potential Role of Oxidative Phosphorylation Inactivation in Diagnosing and Treating Chronic Tendon Injuries [0.03%]
单细胞RNA测序和网络药理学揭示氧化磷酸化的失活在慢性肌腱损伤诊断和治疗中的潜在作用
Jie-Jie Niu,Long Wang,Jia-Chen Qi et al.
Jie-Jie Niu et al.
Background: Chronic tendon injuries, characterized by persistent pain, reduced flexibility, and impaired function, pose a significant clinical challenge. Current therapeutic strategies for these injuries are limited. This...
CXCL14 Promotes Ovarian Cancer Progression and Autophagy Through the IKBKE/NF-κB Pathway [0.03%]
CXCL14通过IKBKE/NF-κB途径促进卵巢癌进展和自噬
Yan Lingling,Rao Yanqiu,Zhu Xuchao et al.
Yan Lingling et al.
Ovarian cancer remains a leading cause of gynecological malignancy-related deaths, necessitating the identification of novel molecular pathways driving tumor progression. Utilizing a data-driven approach, we conducted bioinformatic analyses...
miRNA-Directed Anticancer Strategies: The Emerging Role of Natural Products in Ovarian Cancer [0.03%]
微小核糖核酸在抗癌策略中的作用：天然产物在卵巢癌治疗中的新角色
Rasha Abu-Khudir,Shaza H Aly,Nehal I Rizk et al.
Rasha Abu-Khudir et al.
Ovarian cancer (OC) is still one of the most serious gynecologic malignancies in the world. It is characterized by a significant likelihood of recurrence and resistance to conventional therapies and a lack of efficient screening techniques....
(-)-Epicatechin Regulates Radioresistance in Lung Adenocarcinoma Through ALKBH5 Downregulation of FOXM1 [0.03%]
表没食子儿茶素通过ALKBH5下调FOXM1调节非小细胞肺癌的放射抵抗作用
Hongying Xu,Jie Xia,Anao Wu et al.
Hongying Xu et al.
Lung adenocarcinoma (LUAD), a major subtype of non-small-cell lung cancer, exhibits high incidence and mortality rates. Radiotherapy is a critical treatment modality for LUAD, yet its efficacy is often compromised by radiotherapy resistance...
Anisomycin Induces Senescence and Death of Ovarian Cancer Stem Cells Through the MicroRNA-340/SENP6/SUMOylation Pathway [0.03%]
阿尼西霉素通过MicroRNA-340/SENP6/SUMO化途径诱导卵巢癌干细胞衰老和死亡
Lian Yang,Ye Xia,Zeyu Cui et al.
Lian Yang et al.
Ovarian cancer remains a leading cause of gynecologic cancer mortality, in part due to the persistence of ovarian cancer stem cells (OCSCs) that drive tumor recurrence, metastasis, and drug resistance. Anisomycin, a natural antibiotic deriv...
Multi-Omics Analysis Reveals the Molecular Subtypes and Confirmed the GREM1 as the Core Gene [0.03%]
多组学分析揭示了分子亚型并确认GREM1为核心基因
Zhen-Qing Li,Hui-Rong Huang,Ke-Rong Zhai et al.
Zhen-Qing Li et al.
Research on molecular classification of lung cancer based on transcriptomic features has achieved remarkable progress. The complementary information provided by distinct molecular profiles has motivated the integration of multi-omics datase...
Tumor Immune Contexture Model Predicts Prognosis and Immunotherapy Response in Gastric Cancer [0.03%]
肿瘤免疫构型模型预测胃癌预后及免疫治疗反应
Jiexuan Wang,Xin Yang,Xuan Dai et al.
Jiexuan Wang et al.
Background: Gastric cancer (GC) is highly heterogeneous, and current prognostic models fail to fully capture tumor immune characteristics, limiting personalized treatment. This study introduces the Tumor Immune Environmen...
Facilitating Precision Medicine in HCC Patients by Deep Learning-Directed lncRNAs Classification and Ascertaining Causal Markers [0.03%]
基于深度学习的长链非编码RNA分类及精准医学中因果标志物鉴定促进肝癌患者诊疗研究
Rashi Jain,Sathish Kumar Mungamuri,Prabha Garg
Rashi Jain
Background: Hepatocellular carcinoma (HCC) is a deadly disease, ranking as the fifth most prevalent type of cancer worldwide. To advance precision medicine for HCC, it is imperative to identify novel biomarkers that can f...
Synovial Mesenchymal Stem Cell-Derived Exosomal miR-3614-5p Regulates Macrophage Polarization by Targeting ANXA2 to Relieve Knee Osteoarthritis [0.03%]
滑膜间充质干细胞源外泌体miR-3614-5p通过靶向ANXA2调节巨噬细胞极化缓解膝骨关节炎
Jianli Xue,Jintao Ye,Pei Han et al.
Jianli Xue et al.
Background: Synovial mesenchymal stem cell-derived exosomes (SMSC-Exos) can regulate macrophage polarization and alleviate knee osteoarthritis (KOA). However, the underlying mechanisms remain unclear. This study explored ...