PYCR1 Promotes Esophageal Squamous Cell Carcinoma by Interacting With EGFR to Affecting the PI3K/Akt/mTOR Signaling Pathway [0.03%]
通过与EGFR相互作用影响PI3K/Akt/mTOR信号通路 PYCR1促进食管鳞状细胞癌的发展
Yu-Qi Meng,Hai-Ming Feng,Bin Li et al.
Yu-Qi Meng et al.
Background: The expression and functional role of pyrroline-5-carboxylate reductase 1 (PYCR1) in esophageal squamous cell carcinoma (ESCC) remain poorly understood. This study aimed to elucidate the role and underlying me...
Integrated Single-Cell Transcriptome and eQTL Analyses Reveal the Role of PZP in Aging and Chronic Kidney Disease [0.03%]
整合单细胞转录组和eQTL分析揭示了PZP在衰老及慢性肾病中的作用
Xinhui Huang,Cheng Zhu,Shiqi Lv et al.
Xinhui Huang et al.
Background: Aging is a known driver of chronic kidney disease (CKD), yet the genetic mechanisms linking these two conditions remain unclear. This study aims to explore the role of CD8+ central memory T (TCM) cells and the...
Characterization of Immune Landscape Based on Homologous Recombination Deficiency Associated Signatures and Identification of Knockdown of ERCC6L to Promote Radiosensitivity in Breast Cancer [0.03%]
基于同源重组缺陷相关特征刻画免疫图谱及识别敲低ERCC6L促进乳腺癌放疗敏感性的研究
Jiahao Li,Chen Gong,Haiting Zhou et al.
Jiahao Li et al.
Background: Homologous recombination deficiency (HRD) exhibits significant associations with the occurrence, progression, and prognosis of breast cancer. However, the primary breast cancer HRD positivity rate is merely 24...
The Mechanisms, Research Status, and Future Prospects of m6A Modification in Breast Cancer [0.03%]
m6A修饰在乳腺癌中的机制、研究进展与未来展望
Xiu Xue-Mei,Chen Yang,Ju Wen-Ting et al.
Xiu Xue-Mei et al.
N6-methyladenosine (m6A) modification is a significant methylation alteration frequently observed in eukaryotic RNAs, garnering considerable attention in the field of breast cancer research in recent years. The m6A modification profoundly i...
RNA Interference Targeting Small Heat Shock Protein B8 Failed to Improve Distal Hereditary Motor Neuropathy in the Mouse Model [0.03%]
针对Small Heat Shock Protein B8的RNA干扰未能改善小鼠远端遗传性运动神经病模型的症状
Leen Vendredy,Vicky De Winter,Jonas Van Lent et al.
Leen Vendredy et al.
Background: Missense mutations in the HSPB8 gene, encoding the small heat shock protein B8, cause distal hereditary motor neuropathy (dHMN) or an axonal form of Charcot-Marie-Tooth disease (CMT subtype 2L). Mice expressin...
FOXA3: A Novel Tumor Suppressor in Esophageal Squamous Cell Carcinoma [0.03%]
FOXA3：食管鳞状细胞癌的一种新型肿瘤抑制因子
Siang Zhang,Yuxiang Jin,Qianyu Han et al.
Siang Zhang et al.
Background: The forkhead box A (FOXA) family has been extensively studied in cancer research; however, the role of FOXA3 in malignant tumors, particularly esophageal squamous cell carcinoma (ESCC), is not well understood....
Betulinic Acid Inhibits Glioma Progression by Inducing Ferroptosis Through the PI3K/Akt and NRF2/HO-1 Pathways [0.03%]
白桦酸通过PI3K/AKT和NRF2/HO-1途径诱导铁死亡从而抑制胶质瘤进展
Jinxiang Huang,Qixuan Li,Hongxiang Wang et al.
Jinxiang Huang et al.
Background: Gliomas currently have a poor prognosis and limited therapy options. Betulinic acid (BA) has demonstrated antitumor activity in various cancers. This study is aimed at clarifying the underlying mechanisms by w...
Revealing the Complex Interaction of Noncoding RNAs, Sirtuin Family, and Mitochondrial Function [0.03%]
揭示非编码RNA、Sirtuin家族及线粒体功能之间的复杂相互作用
Ludong Yuan,Leijing Yin,Xiaofang Lin et al.
Ludong Yuan et al.
Mitochondria are key organelles that perform and coordinate various metabolic processes in the cell, and their homeostasis is essential for the maintenance of eukaryotic life. To maintain mitochondrial homeostasis and cellular health, close...
Icariin Facilitates Osteogenic Differentiation and Suppresses Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Enhancing SOST Methylation in Postmenopausal Osteoporosis [0.03%]
淫羊藿苷通过增强SOST甲基化促进骨髓间充质干细胞成骨分化并抑制脂质分化以治疗绝经后妇女的骨质疏松症
Xu Chen,Xizhe Liu,Junming Wan et al.
Xu Chen et al.
Purpose: Postmenopausal osteoporosis (PMO) is mainly concerned with the imbalance of bone resorption and bone formation. Icariin (ICA) plays a vital role in bone protection. This study investigated the mechanism of ICA in...
Idiopathic Pulmonary Fibrosis Is Associated With Type 1 Diabetes: A Two-Sample Mendelian Randomization Study [0.03%]
特发性肺纤维化与1型糖尿病相关性研究：两样本孟德尔随机化研究
Leyan Chen,Tianzhichao Hou,Feifan Ge et al.
Leyan Chen et al.
Background: The pathogenesis of idiopathic pulmonary fibrosis (IPF) remains unclear; previous studies revealed the underlying connection between IPF and diabetes, but there is no consensual opinion. This study is aimed at...