FPPS Downregulation Attenuates Endoplasmic Reticulum Stress in Pulmonary Epithelial Cells [0.03%]
FPPS下调减轻肺上皮细胞内质网应激
Defeng Ye,Chengcheng Zhang,Wencheng Shao et al.
Defeng Ye et al.
The airway epithelium is the primary target of the trachea in lung transplant rejection and epithelial cell injury are frequently observed in lung transplants. Farnesyl pyrophosphate synthase (FPPS), a pivotal enzyme in the mevalonate pathw...
Natural Products and lncRNAs in Renal Cell Carcinoma: Emerging Therapeutic Approaches [0.03%]
天然产物和长链非编码RNA在肾细胞癌中的治疗作用
Ahmed S Doghish,Mai A Abd-Elmawla,Nora M Aborehab et al.
Ahmed S Doghish et al.
Renal cell carcinoma (RCC) is a malignant neoplasm arising from the renal epithelium and constitutes approximately 2% of global cancer diagnoses and mortalities. With increasing prevalence, RCC remains a pressing clinical challenge, particu...
Genome-Wide Study of Diabetes Mellitus (Type 2)-Associated Genes in Homo sapiens (Human) [0.03%]
genome wide 糖尿病(2型)相关基因的全基因组研究(人类)
Rizwan Shaukat,Amjad Hussain,Muhammad Sajid Hamid Akash et al.
Rizwan Shaukat et al.
Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and impaired secretion, necessitating the identification of new markers to target its development and complications. ...
In Silico Analysis of Novel circRNA-miRNA-mRNA Axis in BRAFV600E Melanoma: Implications for Primary to Metastasis Transformation and TIME Modulation [0.03%]
BRAFV600E黑色素瘤中新型circRNA-miRNA-mRNA轴的计算机分析：原发到转移转化和TIME调节的意义
Hemangini Naik,Rajat Choudhary,V Badireenath Konkimalla
Hemangini Naik
Background: The BRAFV600E mutation drives metastatic transition by altering the tumor immune microenvironment (TIME) through transcriptional and post-transcriptional regulation. Recent studies identify circular RNA (circR...
Sp2 Transcription Factor Alleviates Chondrocyte Loss in Osteoarthritis by Repressing the DVL1-Dependent Wnt/β-Catenin Signaling Pathway [0.03%]
SP2转录因子通过抑制DVL1依赖的Wnt/β-catenin信号通路缓解骨关节炎软骨细胞丢失
Yuan Lin,Xinpeng Zheng,Xiaolei Chen et al.
Yuan Lin et al.
Background: Osteoarthritis (OA) ranks as the most prevalent condition affecting the musculoskeletal system, where chondrocyte loss or dysfunction plays a crucial pathogenic role. This study is aimed at investigating key m...
Exploring the Links Between Micronutrients and Cardiac Traits: Roles of Vitamins A1, B9, and D [0.03%]
微营养素与心脏特征之间的关系探究：维生素A1、B9和D的作用
Lingwei Liu,Yongxi Cheng,Shujun Yan et al.
Lingwei Liu et al.
Objective: Micronutrients, such as vitamins and minerals, are essential for cardiac health, but their effects on cardiac structure and function remain unclear. This study aimed to investigate the causal impact of micronut...
Identifying GAP43, NMU, and TEX29 as Potential Prognostic Biomarkers for COPD Combined With Lung Cancer Patients Using Machine Learning [0.03%]
利用机器学习识别GAP43、NMU和TEX29作为慢性阻塞性肺疾病合并肺癌患者的潜在预后生物标志物
Zhilong Xu,Kaiyao Zhang,Ao Zeng et al.
Zhilong Xu et al.
Chronic obstructive pulmonary disease (COPD) and lung cancer, frequently comorbid conditions intricately linked through smoking, represent significant global health challenges. COPD is a common comorbidity in nonsmall cell lung cancer (NSCL...
Natural Products as Modulators of miRNA in Hepatocellular Carcinoma: A Therapeutic Perspective [0.03%]
天然产物作为肝细胞癌中miRNA调制剂的治疗视角
Shahzada Khalid Sohail
Shahzada Khalid Sohail
Hepatocellular carcinoma (HCC) continues to pose a substantial worldwide health concern, marked by elevated mortality rates and restricted therapeutic alternatives. Recent studies have highlighted the potential of natural compounds as thera...
Adoptive Transfer of T Cells as a Potential Therapeutic Approach in the Bleomycin-Injured Mouse Lung [0.03%]
在抗坏血酸损伤的小鼠肺中采用转移T细胞作为潜在的治疗手段
Seyran Mutlu,Kleanthis Fytianos,Céline Ferrié et al.
Seyran Mutlu et al.
Background: Idiopathic pulmonary fibrosis (IPF) is a lethal disease with an unknown etiology and complex pathophysiology that are not fully understood. The disease involves intricate cellular interplay, particularly among...
USF2-Mediated Transcription of BZW2 Contributes to CRC Malignant Progression by Affecting LAMP3 [0.03%]
USF2介导的BZW2转录通过影响LAMP3促进CRC恶性进展
Xintao Li,Yizhi Liu,Shuang Liu et al.
Xintao Li et al.
Background: Colorectal cancer (CRC) is one of the most frequent causes of cancer death in China, and its occurrence, development, and prognosis are closely related to the living state of patients. Basic leucine zipper and...