Mechanism of Tourette Syndrome Induced by ABGA-Mediated CaMKII-TH Pathway [0.03%]
ABGA介导的CaMKII-TH通路诱导抽动症的机制研究
Xinnan Wu,Juanjuan Hao,Keyu Jiang et al.
Xinnan Wu et al.
Background: In this study, we intend to investigate the mechanism by which anti-basal ganglia antibodies (ABGA) modulate dopamine release through the CaMKII-TH pathway, which leads to the onset of Tourette syndrome (TS). ...
miRNA-574-5p and miRNA-522 as Potential Biomarkers in Nonalcoholic Fatty Liver Disease [0.03%]
miRNA-574-5p和miRNA-522作为非酒精性脂肪肝病的潜在生物标志物
Reham Fares,Asmaa Mohammed,Mahmoud A F Khalil et al.
Reham Fares et al.
Nonalcoholic fatty liver disease (NAFLD) forms a global health burden with prominent incidence rates exceeding 26%, possessing a versatile spectrum of presentations starting from benign liver steatosis and deteriorating to hepatic fibrosis ...
Liver Enzyme Genetics and Health Conditions in East Asians: Genetic Architecture and Causal Insights [0.03%]
东亚人群肝酶遗传与健康状况：遗传结构和因果关系研究
Ying-Ju Lin,Jai-Sing Yang,Ju-Pi Li et al.
Ying-Ju Lin et al.
Background: Elevated serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are biomarkers of liver dysfunction and predictors of cirrhosis and liver cancer. While European-ancestry GWAS have ...
Claudin-1, a Biomarker of Epithelial-Mesenchymal Transformation, Enhances Lipid Metabolism in Colorectal Cancer Cells to Promote Tumor Metastasis [0.03%]
Claudin-1通过促进结直肠癌细胞脂质代谢增强上皮间质转化以促进肿瘤转移
Yaqi Qu,Zeyu Li,Lifei Tian et al.
Yaqi Qu et al.
Claudin-1 (CLDN1), a vital tight junction protein, is linked to epithelial-mesenchymal transition (EMT) of tumor cells. In this study, multi-omics including expression profiles of colorectal cancer (CRC) from The Cancer Genome Atlas (TCGA) ...
TRIM34-Mediated Ubiquitination and Degradation of HIF-1A Regulates Glycolysis in Endothelial Cells, Inhibits Angiogenesis, and Relieves the Progression of Lung Fibrosis [0.03%]
TRIM34介导的HIF-1A泛素化及降解调节内皮细胞糖酵解、抑制新生血管生成并缓解肺纤维化进程
Chunyan Yang,Qing Liu,Bing Chen et al.
Chunyan Yang et al.
Idiopathic interstitial pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by interstitial fibrosis, with poor prognosis and high mortality. TRIM34 is involved in the intracellular ubiquitination process, but its me...
Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells in Patients With Single Ventricle/Hypoplastic Left Heart Syndrome [0.03%]
单心室/左心发育不全综合征患者外周血单个核细胞的单细胞RNA测序
Hui-Qi Qu,Kayleigh Ostberg,Diana J Slater et al.
Hui-Qi Qu et al.
Background: Single ventricle and hypoplastic left heart syndrome (SV/HLHS) has detrimental effects on multiple organ systems, including peripheral blood mononuclear cells (PBMCs), and can weaken the immune system, exacerb...
Insights Into the Dysfunctional Communication Switches Targeting Osteocyte Mechanotransduction and Lacunar-Canalicular Gene Network in Pathogenesis of Osteoarthritis [0.03%]
骨关节炎发病机制中靶向破骨细胞机械转导和腔穴-小管基因网络的功能性通讯开关的见解
Shahneela Nusrat,Rahman Ud Din,Muhammad Akram Tariq et al.
Shahneela Nusrat et al.
Osteoarthritis (OA) is a degenerative condition of bone characterized by loss of cartilage, subchondral bone sclerosis, osteophyte growth, synovial inflammation, and influenced by biomechanical loading. The loss of articular cartilage is th...
The Role of MiRNAs in Moyamoya Disease: Vascular Remodeling and Stroke Risk [0.03%]
缺血性脑卒中患者外周血miR-15a和miR-16表达及临床意义
Heba Ibrahim Abd El-Moaty,Ahmed S Doghish,Reda M Mansour et al.
Heba Ibrahim Abd El-Moaty et al.
Moyamoya disease (MMD) is a rare degenerative stenosis and occlusive cerebrovascular illness. It is characterized by cerebral ischemia and/or cerebral hemorrhage as the two main clinical signs. It is a common cause of stroke in both childre...
Hypoxia-Inducible Factor HIF1α Regulates the Expression of SLC7A1 to Mediate Erastin-Induced Ferroptosis in Cervical Cancer Cells [0.03%]
缺氧诱导因子HIF1α通过调控SLC7A1介导宫颈癌细胞中erasin诱导的铁死亡现象
Yanqing Huang,Yan Lei,Yanling Li
Yanqing Huang
Objective: This study aims to investigate the regulation of hypoxia-inducible factor 1α (HIF1α) on cationic amino acid transporter 1 (SLC7A1) expression and its potential mechanism YTH N6-methyladenosine RNA binding pro...