Genetic Relationship Between Menarche and Height in East Asians: Functional Role of LIN28B in Pubertal Timing and Growth [0.03%]
东亚人月经与身高的遗传关系：LIN28B在青春期时间和生长中的功能作用
Ying-Ju Lin,Ju-Pi Li,Hou-Ren Chen et al.
Ying-Ju Lin et al.
Background: Observational and genetic studies associate later menarche with greater height, but their causal relationship, shared genomic regions, and LIN28B's role in puberty and growth remain unclear. ...
De Novo Missense Variant in TP63 Gene: Insights on Clinical and Molecular Investigations [0.03%]
TP63基因新发错义突变的临床及分子特征研究初报
Jilong Chen,Xufeng Xi,Xiaoman Xu et al.
Jilong Chen et al.
Objective: This study aims to investigate the phenotypes, mutation types, and loci associated with TP63-related syndrome by focusing on an affected proband. ...
Natural Products and LncRNAs in Non-Small Cell Lung Cancer: Emerging Therapeutic Approaches [0.03%]
天然产物和长链非编码RNA在非小细胞肺癌治疗中的新思路
Ahmed S Doghish,Mai A Abd-Elmawla,Heba R Ghaiad et al.
Ahmed S Doghish et al.
Non-small cell lung cancer (NSCLC) is considered a major contributor to cancer-related death rates worldwide, chiefly owing to late diagnosis, occurrence of metastasis, and treatment resistance. Growing evidence underscores the impact of lo...
KDM1A Facilitates Oncogenic Potential in Colorectal Cancer Progression Through the Activation of AXIN/GSK3β/β-Catenin Signaling Pathways: Evidence From Integrated Transcriptomics and In Vitro Studies [0.03%]
KDM1A通过激活AXIN/GSK3β/β-连环蛋白信号通路促进结直肠癌进展的致癌潜能：来自整合转录组学和体外研究的证据
Sathan Raj Natarajan,Rajapandiyan Krishnamoorthy,Mohammad A Alshuniaber et al.
Sathan Raj Natarajan et al.
Background: Colorectal cancer (CRC) is a major cause of cancer-related death and is driven by epigenetic alterations. KDM1A, a key histone demethylase, has a poorly defined role in CRC. This study investigates its molecul...
Identification of the Role of Transient Receptor Potential Channels in Acute Pancreatitis [0.03%]
瞬时受体电位通道在急性胰腺炎中作用的探讨
Shuangjun Shen,Xiaowan Wu,Zhiyuan Cheng et al.
Shuangjun Shen et al.
Background: Acute pancreatitis (AP) is a severe inflammatory disease. Transient receptor potential (TRP) channels have been reported to participate in various pathophysiological processes. However, the role of TRP channel...
MicroRNA Profile Predicts Tumor Spread Through Air Spaces in Resected Lung Adenocarcinomas: A Pilot Study [0.03%]
微小核糖核酸谱系可预测肺腺癌手术切除标本中肿瘤通过空气间隙扩散的情况：一项初步研究
Chihiro Yoshida,Kyuichi Kadota,Futoshi Suizu et al.
Chihiro Yoshida et al.
Background: Spread through air spaces (STAS), a mode of lung cancer progression, is recognized as a poor prognostic factor, although its pathogenesis remains unclear. This study aimed to identify microRNAs (miRNAs) associ...
Molecular Crosstalk Between Osteoporosis and Osteosarcoma: Identification of Common Diagnostic Markers and Therapeutic Targets [0.03%]
骨质疏松和骨肉瘤之间的分子相互作用：共同诊断标志物和治疗靶点的鉴定
Yong Zhou,Jianxin Huang
Yong Zhou
Background: Osteoporosis and osteosarcoma share certain molecular pathways, and identifying common hub genes could provide new insights into their pathogenesis. This study aimed to identify and validate hub genes involved...
Targeting Circular RNAs (circRNAs) in Atherosclerosis Using CRISPR Technology [0.03%]
使用CRISPR技术靶向环形RNA（circRNA）治疗动脉粥样硬化
Areej Nazarudeen,V A Aswathy,Arun A Rauf et al.
Areej Nazarudeen et al.
Atherosclerosis is a chronic inflammatory condition that remains a major global cause of cardiovascular morbidity and death. Circular RNAs (circRNAs), emerging as key regulators of biological processes, have been linked to atherosclerosis b...
Milen Velinov
Milen Velinov
Fragile X syndrome (FXS) is the most common single gene cause of inherited intellectual disability and autism spectrum disorder (ASD). FMR1, the gene associated with FXS, is located on chromosome X. Accordingly, males with loss-of-function ...
Yiming Chen,Mengting Wang,Xiaoliang Cao et al.
Yiming Chen et al.
Diabetes mellitus (DM) is a chronic metabolic disease, and some diabetic patients develop diabetic foot ulcers (DFU), which are one of the most prevalent and serious complications among diabetic patients. These ulcers can lead to neuropathy...