Facilitating Precision Medicine in HCC Patients by Deep Learning-Directed lncRNAs Classification and Ascertaining Causal Markers [0.03%]
基于深度学习的长链非编码RNA分类及精准医学中因果标志物鉴定促进肝癌患者诊疗研究
Rashi Jain,Sathish Kumar Mungamuri,Prabha Garg
Rashi Jain
Background: Hepatocellular carcinoma (HCC) is a deadly disease, ranking as the fifth most prevalent type of cancer worldwide. To advance precision medicine for HCC, it is imperative to identify novel biomarkers that can f...
Synovial Mesenchymal Stem Cell-Derived Exosomal miR-3614-5p Regulates Macrophage Polarization by Targeting ANXA2 to Relieve Knee Osteoarthritis [0.03%]
滑膜间充质干细胞源外泌体miR-3614-5p通过靶向ANXA2调节巨噬细胞极化缓解膝骨关节炎
Jianli Xue,Jintao Ye,Pei Han et al.
Jianli Xue et al.
Background: Synovial mesenchymal stem cell-derived exosomes (SMSC-Exos) can regulate macrophage polarization and alleviate knee osteoarthritis (KOA). However, the underlying mechanisms remain unclear. This study explored ...
Artificial Intelligence for Predictive Modeling in CRISPR/Cas9 Gene Editing: a Survey of Methods and Design Strategies [0.03%]
基于CRISPR/Cas9基因编辑的预测建模的人工智能方法及设计策略综述
Jay Patel,Dhruvi Patel,Aanal Raval
Jay Patel
Ongoing developments in genome editing most notably the continued evolution of CRISPR-Cas systems and their orthogonal or modified counterparts have substantively altered both experimental and applied practices in biomedicine, agriculture, ...
miRNAs in Erdheim-Chester Disease: A Paradigm of Multisystem Histiocytosis [0.03%]
Erdheim-Chester病中的miRNA：多系统组织细胞增生症的典范
Mohamed Hemdan,Reda M Mansour,Hebatallah Ahmed Mohamed Moustafa et al.
Mohamed Hemdan et al.
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis identified in the early 20th century. ECD primarily affects adults and is characterized by systemic infiltration of foamy macrophages. ECD can infiltrate the bones, s...
Ferroptosis-Related Gene SAT1 Contributes to Immune Responses in Acute Pancreatitis [0.03%]
铁死亡相关基因SAT1在急性胰腺炎中参与免疫反应
Kena Zhou,Congbo Cai,Rong Wan et al.
Kena Zhou et al.
Background: Ferroptosis and immune responses are catching more and more attention in inflammatory diseases. However, the specific function and mechanism of the popular ferroptosis-related gene SAT1 in acute pancreatitis (...
THBS1 Contributes to Chemoresistance in Ovarian Clear Cell Carcinoma via Promoting Epithelial-Mesenchymal Transition [0.03%]
THBS1通过促进上皮间质转化介导卵巢透明细胞癌化疗耐药性
Dongdong Ye,Yunyun Liu,Aoshuang Cheng et al.
Dongdong Ye et al.
Objective: Ovarian clear cell carcinoma (OCCC) is prone to primary platinum resistance and has a poor prognosis in advanced stages. Understanding the mechanisms underlying chemoresistance is essential to improving treatme...
A-to-I RNA Edited miR-605-3p Has a Heightened Anti-Tumor Effect in Colorectal Cancer Through Modulating Immune Infiltration Mediated by CDK6 [0.03%]
A至I的RNA编辑miR-605-3p通过CDK6介导的免疫浸润调节 colorectal cancer肿瘤抑制作用增强
Xi-Zhong Cai,Dan-Yang Li,Kuang Gou et al.
Xi-Zhong Cai et al.
Background: Adenosine-to-inosine (A-to-I) RNA editing represents a prevalent post-transcriptional modification with profound implications for human diseases, particularly cancer. In colorectal cancer (CRC), the specific r...
The Role of the CLIC/GEEC Endocytic Pathway for Mechanophysical Transfection of DNA [0.03%]
CLIC/GEEC内吞途径在DNA力学转染中的作用
Sean Weaver,Emran O Lallow,Kelly Kyker-Snowman et al.
Sean Weaver et al.
The clathrin-independent carriers/glycosylphosphatidylinositol-attached protein-enriched endosomal compartments (CLIC/GEEC) pathway is a clarithin- and dynamin-independent endocytic pathway. CLIC/GEEC-mediated endocytosis is a large-capacit...
YTHDF3 Promotes N6-Methyladenosine Modification of SOCS1 to Inhibit JAK1/STAT3 Pathway in the Pathogenesis of Preeclampsia [0.03%]
YTHDF3通过促进SOCS1的N6-甲基腺苷修饰抑制JAK1/STAT3信号通路以参与子痫前期发病机制
Shuang Sui,Xinchun Wang,Yanmei Zhang et al.
Shuang Sui et al.
Preeclampsia (PE) is a common complication during pregnancy. Trophoblast cells are the main cell type of the placenta, and abnormalities in proliferation and differentiation cause anterior placental accretion and lead to the development of ...
A Pan-Cancer Analysis of the Oncogenic Role of YES Proto-Oncogene 1 (YES1) in Human Tumors [0.03%]
泛癌症分析YES原癌基因1（YES1）在人类肿瘤中的致癌作用
Ruohan Dou,Ling Han,Guanya Liu et al.
Ruohan Dou et al.
Background: Numerous studies have underscored the oncogenic function of YES Proto-Oncogene 1 (YES1) in various tumors. However, the relationship between YES1 and different tumors in pan-cancer patients, based on extensive...