The activation of asparagine synthetase by the transcription factor FOXM1 plays a pivotal role in the initiation and progression of ESCC [0.03%]
FOXM1转录因子激活天冬酰胺合成酶在食管鳞癌发生发展中的关键作用
Jing-Jing Lian,Zhao-Xing Li,Hui-Ling Lin et al.
Jing-Jing Lian et al.
This study explores the role of the transcription factor FOXM1 in the initiation and progression of oesophageal squamous cell carcinoma (ESCC). Our findings reveal that FOXM1 is highly expressed in ESCC and correlates with the prognosis of ...
Dipeptidyl peptidase 4: A predictor of ferroptosis in ulcerative colitis [0.03%]
二肽基肽酶4：预测溃疡性结肠炎铁死亡的标志物
Fuyun Zhu,Dezeng Zou,Ping Shi et al.
Fuyun Zhu et al.
Background: With its rapidly increasing incidence and prevalence, ulcerative colitis (UC) has become a major global health challenge. Recent evidence suggests that ferroptosis plays a significant role in the development o...
Causal effects of female reproductive features on nonalcoholic fatty liver disease: A mendelian randomization study [0.03%]
女性生殖特征对非酒精性脂肪肝疾病因果效应的孟德尔随机化研究
Haoshuang Fu,Shuying Song,Bingying Du et al.
Haoshuang Fu et al.
Background and aims: Epidemiological evidence on the associations between female reproductive features and nonalcoholic fatty liver disease (NAFLD) is conflicting. To explore their causalities, we conducted a Mendelian ra...
Single-cell RNA sequencing reveals microenvironmental infiltration in non-small cell lung cancer with different responses to immunotherapy [0.03%]
单细胞RNA测序揭示非小细胞肺癌不同的免疫治疗反应与肿瘤微环境浸润之间的关系
Xinnan Hu,Yonghui Wu,Lixin Wang et al.
Xinnan Hu et al.
Background: Immunotherapy represents a groundbreaking and monumental achievement in the field of cancer therapy, marking a significant advancement in fighting against this devastating disease. Lung cancer has showed consi...
Exploring the interplay between bisphenol A exposure, the immune microenvironment and hepatocellular carcinoma progression [0.03%]
探索双酚A暴露、免疫微环境与肝癌进展之间的相互作用
Qi Liu,Ruishu Niu,Yi Ye et al.
Qi Liu et al.
Background: Hepatocellular carcinoma (HCC) remains a formidable challenge in oncology, with its pathogenesis and progression influenced by myriad factors. Among them, the pervasive organic synthetic compound, bisphenol A ...
Oncogenic tRNA-derived fragment tRF-Leu-CAG promotes tumorigenesis of lung cancer via targeting TCEA3 and increasing autophagy [0.03%]
癌基因tRF-tRF-Leu-CAG通过靶向TCEA3并增加自噬促进肺癌肿瘤发生发展
Fan Wu,Binshu Chai,Pengfei Qi et al.
Fan Wu et al.
Background: Lung cancer is a prevalent and severe form of malignant tumors worldwide. tRF-Leu-CAG, a recently discovered non-coding single-stranded small RNA derived from transfer RNA, has sparked interest in exploring it...
Integrative in silico approaches to analyse microRNA-mediated responses in human diseases [0.03%]
整合的计算机方法分析人类疾病中的微小核糖核酸介导的反应
Meghna Agrawal,Ashutosh Mani
Meghna Agrawal
Advancements in sequencing technologies have facilitated omics level information generation for various diseases in human. High-throughput technologies have become a powerful tool to understand differential expression studies and transcript...
Leveraging SEER data through machine learning to predict distant lymph node metastasis and prognosticate outcomes in hepatocellular carcinoma patients [0.03%]
利用机器学习挖掘SEER数据库预测肝细胞癌患者远处淋巴结转移及预后
Jiaxuan Sun,Lei Huang,Yahui Liu
Jiaxuan Sun
Objectives: This study aims to develop and validate machine learning-based diagnostic and prognostic models to predict the risk of distant lymph node metastases (DLNM) in patients with hepatocellular carcinoma (HCC) and t...
Strategic deactivation of mRNA COVID-19 vaccines: New applications for siRNA therapy and RIBOTACs [0.03%]
策略性停用mRNA新冠疫苗：siRNA治疗和RIBOTAC的新应用
Nicolas Hulscher,Peter A McCullough,Diane E Marotta
Nicolas Hulscher
The rapid development and authorization of messenger ribonucleic acid (mRNA) vaccines by Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1273) in 2020 marked a significant milestone in human mRNA product application, overcoming previous obstac...
mRNA expression insights: Unraveling the relationship between COPD and lung cancer [0.03%]
从mRNA表达角度揭示慢性阻塞性肺疾病与肺癌之间的关系
Zhan Gu,Jijia Sun,Lixin Wang
Zhan Gu
Background: Lung cancer is a prevalent form of cancer worldwide. A possible link between lung cancer and chronic obstructive pulmonary disease (COPD) has been suggested by recent studies. The objective of our research was...