In Vivo Assessment of dbDNA GNEwt/bi-shRNA-GNEM743T Lipoplex for GNE Myopathy: Improved Potency and Safety [0.03%]
体内评估用于治疗GNE肌病的dbDNA GNEwt / bi-shRNA-GNEM743T脂质plex：更有效的效力和安全性
Christopher M Jay,Fabienne Kerneis,Donald Rao et al.
Christopher M Jay et al.
GNE myopathy is an autosomal recessive disease, associated with skeletal muscle deterioration, which afflicts young adults. GNE plays a pivotal role in sialic acid production. Sialic acid acts as a buffer against reactive oxygen species gen...
F2R Promotes Prostate Cancer Progression via COL8A1-Dependent Activation of the FAK/PI3K/AKT Signaling Axis [0.03%]
F2R通过依赖COL8A1的FAK/PI3K/AKT信号轴活化促进前列腺癌进展
Xianfan Ding,Jinrun Wang,Jinzhuo Ning et al.
Xianfan Ding et al.
Background: In males, prostate cancer (PCa) is one of the frequently diagnosed forms of cancer, with high clinical variability and limited treatment options for advanced cases. This receptor, which goes by the names Coagu...
Rational Design and Optimisation of CRISPR-Cas9 Delivery Systems for Targeted Genomic Transformation [0.03%]
合理设计和优化CRISPR-Cas9递送系统以实现靶向基因组转化
Kalpana Pandya,Likshit S Jaisinghani,Avanish Tripathi et al.
Kalpana Pandya et al.
The CRISPR-Cas9 genome-editing technique offers a promising therapeutic strategy for genetic disorders, including neurodegenerative diseases like Alzheimer's disease (AD), characterised by inherited susceptibility and progressive cognitive ...
CD74 Affects Ferroptosis in Traumatic Brain Injury by Modulating the Nrf2/HO-1 Signaling Pathway [0.03%]
CD74通过调节Nrf2/HO-1信号通路影响创伤性脑损伤中的铁死亡
GuangWei Sun,Jie Li,Meng Wang et al.
GuangWei Sun et al.
Objective: This study aimed to explore whether CD74 participates in regulating ferroptosis and to clarify the related mechanisms in traumatic brain injury (TBI). ...
Empagliflozin Ameliorates Angiotensin II-Induced Left Ventricular Diastolic Dysfunction by Suppressing EndoMT via PI3K/AKT/eNOS Signaling [0.03%]
恩格列净通过PI3K/AKT/eNOS信号通路抑制内皮-间质转化改善血管紧张素Ⅱ诱导的左心室舒张功能障碍
Dong-Li Shen,Zi-Mu Wang,Yan-Yan Wang et al.
Dong-Li Shen et al.
Background: The SGLT2 inhibitor empagliflozin (EMPA) has been found to reduce the combined risk of cardiovascular death or hospitalization for heart failure in patients with or without reduced left ventricular ejection fr...
Vitamin D Mitigates Klebsiella pneumoniae-Induced Pneumonia by Regulating Macrophage Polarization Through miR-223/ACSL3 Axis-Mediated Lipid Metabolism Reprogramming [0.03%]
维生素D通过miR-223/ACSL3轴介导的脂质代谢重编程调节巨噬细胞极化来缓解肺炎克雷伯菌诱导的肺炎
Jiajia Hu,Yushen Lin,Wanrong Guo et al.
Jiajia Hu et al.
Background: Pneumonia caused by Klebsiella pneumonia (Kp) poses a significant risk to global public health. Vitamin D may reduce Kp infection risk and improve prognosis through immunomodulation. This study aimed to valida...
CRISPR-Cas Systems in Human Disease Therapy: Advances, Clinical Applications, Limitations, and Future Directions [0.03%]
人类疾病治疗中的CRISPR-Cas系统：进展、临床应用、局限性及未来方向
Gedion Mengistu
Gedion Mengistu
CRISPR-Cas systems have emerged as versatile platforms for targeted genome and transcriptome engineering, enabling precise manipulation of disease-associated genetic pathways. Continued advances in CRISPR technologies including base editing...
Further Evidence for LRRC7 Gene Involvement in Neurodevelopmental Disorder: A Novel Variant [0.03%]
进一步证明LRRC7基因参与神经发育性疾病：一个新的变异体
Shazia Khan,Muhammad Bilal,Hammal Khan et al.
Shazia Khan et al.
Background: Neurodevelopmental disorders (NDDs) are clinically heterogeneous conditions with complex etiologies and limited therapeutic options. Here, we investigated a proband presenting global developmental delay (GDD),...