Antoine Hocher,Angela Taddei
Antoine Hocher
Specificities associated with chromosomal linearity are not restricted to telomeres. Here, recent results obtained on fission and budding yeast are summarized and an attempt is made to define subtelomeres using chromatin features extending ...
Commensal Rats and Humans: Integrating Rodent Phylogeography and Zooarchaeology to Highlight Connections between Human Societies [0.03%]
共栖老鼠与人类：整合啮齿动物谱系地理学和动物园考古学以突出人类社会之间的联系
Emily E Puckett,David Orton,Jason Munshi-South
Emily E Puckett
Phylogeography and zooarchaeology are largely separate disciplines, yet each interrogates relationships between humans and commensal species. Knowledge gained about human history from studies of four commensal rats (Rattus rattus, R. tanezu...
Did Acidic Stress Resistance in Vertebrates Evolve as Na+ /H+ Exchanger-Mediated Ammonia Excretion in Fish? [0.03%]
无机离子交换在鱼类排氨中的作用及其在脊椎动物抗酸应激中的进化意义
Yung-Che Tseng,Jia-Jiun Yan,Fumiya Furukawa et al.
Yung-Che Tseng et al.
How vertebrates evolved different traits for acid excretion to maintain body fluid pH homeostasis is largely unknown. The evolution of Na+ /H+ exchanger (NHE)-mediated NH4+ excretion in fishes is reported, and the coevolution with increased...
Stress Responses Co-Opted for Specialized Cell Types During the Early Evolution of Multicellularity: The Role of Stress in the Evolution of Cell Types Can Be Traced Back to the Early Evolution of Multicellularity [0.03%]
多细胞生物早期进化过程中应激反应被用于专门的细胞类型：应激在细胞类型的进化中可以追溯到多细胞生物早期的进化过程中的作用
Aurora M Nedelcu,Richard E Michod
Aurora M Nedelcu
Debating Eukaryogenesis-Part 2: How Anachronistic Reasoning Can Lure Us into Inventing Intermediates [0.03%]
争论真核细胞的起源（二）：陈旧过时的推理会使我们杜撰出中间过渡型祖先？
Dave Speijer
Dave Speijer
Eukaryotic origins are inextricably linked with the arrival of a pre-mitochondrion of alphaproteobacterial-like ancestry. However, the nature of the "host" cell and the mode of entry are subject to heavy debate. It is becoming clear that th...
Developmental Transcriptional Enhancers: A Subtle Interplay between Accessibility and Activity: Considering Quantitative Accessibility Changes between Different Regulatory States of an Enhancer Deconvolutes the Complex Relationship between Accessibility and Activity [0.03%]
发育转录增强子：可接近性和活性之间的微妙平衡：考虑增强子的不同调控状态之间定量的可接近性变化可以澄清可接近性和活性之间的复杂关系
Marta Bozek,Nicolas Gompel
Marta Bozek
Measurements of open chromatin in specific cell types are widely used to infer the spatiotemporal activity of transcriptional enhancers. How reliable are these predictions? In this review, it is argued that the relationship between the acce...
Do Smartphones Create a Coordination Problem for Face-to-Face Interaction? Leveraging Game Theory to Understand and Solve the Smartphone Dilemma [0.03%]
智能手机创造了面对面交流中的协调问题吗？利用博弈论来理解并解决智能手机带来的困境
Athena Aktipis,Roger Whitaker,Jessica D Ayers
Athena Aktipis
Smartphone use changes the landscape of social interactions, including introducing new social dilemmas to daily life. The challenge of putting down one's smartphone is an example of a classic coordination problem from game theory: the stag ...
YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy [0.03%]
YAP/TAZ：肿瘤生长、转移和治疗抵抗的驱动因素
Barry J Thompson
Barry J Thompson
The transcriptional co-activators YAP (or YAP1) and TAZ (or WWTR1) are frequently activated during the growth and progression of many solid tumors, including lung, colorectal, breast, pancreatic, and liver carcinomas as well as melanoma and...
Biomarkers for Early Cancer Diagnosis: Prospects for Success through the Lens of Tumor Genetics [0.03%]
肿瘤遗传学视角下的癌症早期诊断生物标志物的成功前景
Tommaso A Dragani,Valerie Matarese,Francesca Colombo
Tommaso A Dragani
Thousands of candidate cancer biomarkers have been proposed, but so far, few are used in cancer screening. Failure to implement these biomarkers is attributed to technical and design flaws in the discovery and validation phases, but a major...
Replication Fork Barriers and Topological Barriers: Progression of DNA Replication Relies on DNA Topology Ahead of Forks [0.03%]
复制子屏障和拓扑屏障：DNA 复制的进行依赖于叉前端的拓扑结构
Jorge B Schvartzman,Pablo Hernández,Dora B Krimer
Jorge B Schvartzman
During replication, the topology of DNA changes continuously in response to well-known activities of DNA helicases, polymerases, and topoisomerases. However, replisomes do not always progress at a constant speed and can slow-down and even s...