Are Anaphase Events Really Irreversible? The Endmost Stages of Cell Division and the Paradox of the DNA Double-Strand Break Repair [0.03%]
分裂期末期事件真的不可逆吗？DNA双链断裂修复的悖论
Félix Machín,Jessel Ayra-Plasencia
Félix Machín
It has been recently demonstrated that yeast cells are able to partially regress chromosome segregation in telophase as a response to DNA double-strand breaks (DSBs), likely to find a donor sequence for homology-directed repair (HDR). This ...
Alexa Sadier,William R Jackman,Vincent Laudet et al.
Alexa Sadier et al.
Teeth are one of the most fascinating innovations of vertebrates. Their diversity of shape, size, location, and number in vertebrates is astonishing. If the molecular mechanisms underlying the morphogenesis of individual teeth are now relat...
Palmitoylated Proteins in Plasmodium falciparum-Infected Erythrocytes: Investigation with Click Chemistry and Metabolic Labeling [0.03%]
Plasmodium falciparum感染的红细胞中的棕榈酰化蛋白质：使用点击化学和代谢标记进行研究
Nicole Kilian,Yongdeng Zhang,Lauren LaMonica et al.
Nicole Kilian et al.
The examination of the complex cell biology of the human malaria parasite Plasmodium falciparum usually relies on the time-consuming generation of transgenic parasites. Here, metabolic labeling and click chemistry are employed as a fast tra...
Peiyan Ni,Sangmi Chung
Peiyan Ni
Schizophrenia (SCZ) is a severe neurodevelopmental disorder affecting 1% of populations worldwide with a grave disability and socioeconomic burden. Current antipsychotic medications are effective treatments for positive symptoms, but poorly...
Biogenic Iron Preserves Structures during Fossilization: A Hypothesis: Iron from Decaying Tissues May Stabilize Their Morphology in the Fossil Record [0.03%]
生物铁在化石化过程中保存结构的作用：假说：腐烂组织中的铁可能在其形态进入化石记录时稳定其形态
Farid Saleh,Allison C Daley,Bertrand Lefebvre et al.
Farid Saleh et al.
It is hypothesized that iron from biological tissues, liberated during decay, may have played a role in inhibiting loss of anatomical information during fossilization of extinct organisms. Most tissues in the animal kingdom contain iron in ...
AUG as the Translation Start Codon in Circular RNA Molecules: A Connection between Protein-Coding Genes and Transfer RNAs? [0.03%]
环状RNA分子中的AUG作为起始密码子：蛋白质编码基因与转移RNA之间的联系？
Paweł Mackiewicz
Paweł Mackiewicz
Peptidylprolylisomerases, Protein Folders, or Scaffolders? The Example of FKBP51 and FKBP52 [0.03%]
肽基-脯氨酰异构酶：分子伴侣还是支架蛋白？FKBP51和FKBP52为例证
Theo Rein
Theo Rein
Peptidylprolyl-isomerases (PPIases) comprise of the protein families of FK506 binding proteins (FKBPs), cyclophilins, and parvulins. Their common feature is their ability to expedite the transition of peptidylprolyl bonds between the cis an...
Heritable Epigenetic Changes Alter Transgenerational Waveforms Maintained by Cycling Stores of Information [0.03%]
可以跨世代传递的表观遗传变化及其调控机制研究报告
Antony M Jose
Antony M Jose
Our view of heredity can potentially be distorted by the ease of introducing heritable changes in the replicating gene sequences but not in the cycling assembly of regulators around gene sequences. Here, key experiments that have informed t...