Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration [0.03%]
线粒体微蛋白：神经发育和神经变性中新兴的调节因子
Nada Borghol,Sozerko Yandiev,Julien Courchet
Nada Borghol
Recent advances in genomics uncovered a large number of microproteins, which are peptides of less than 100 amino-acids encoded by small open reading frames. In contrast to their identification, the validation of the functions of microprotei...
Yang Niu,Tamas Balla
Yang Niu
Although the inner nuclear membrane (INM) is generally considered to be continuous with the outer nuclear membrane (ONM) and connected to the remaining endoplasmic reticulum (ER), it has been well recognized that it is functionally distinct...
How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration: Shared Mechanisms Between Growth Cones of Migrating Neurons and Axons [0.03%]
生长锥如何感知细胞外线索并驱动神经元迁移：迁徙中的神经元的生长锥和轴突生长锥之间的共有机制
Takahiro Kanzawa,Chikako Nakajima,Masato Sawada et al.
Takahiro Kanzawa et al.
Migrating neurons form a growth cone at the tip of their leading process. This specialized structure shares striking anatomical and functional similarities with axonal growth cones. We hypothesize that both cones respond to common extracell...
Lucia Sylvain-Bonfanti,Delphine Arbelet-Bonnin,Christophe Lalanne et al.
Lucia Sylvain-Bonfanti et al.
Because of their interest in medicine, most studies on anesthesia have historically focused on the nervous systems of animals. This has often led to the neglect of the fact that all life forms have the potential to be anesthetized. Anesthet...
Defective Ribosome Recycling: A Bridge Between Translation Fidelity, Organelle Dysfunction, and Diseases: Exploring How Flawed Ribosome Recycling Factors Impact Ribosome Metabolism and Organelle Homeostasis, Leading to Human Diseases [0.03%]
缺陷的核糖体循环：翻译保真度、细胞器功能障碍和疾病之间的桥梁：探索有缺陷的核糖体循环因子如何影响核糖体代谢和细胞器稳态，从而导致人类疾病
Foozhan Tahmasebinia,Zhihao Wu
Foozhan Tahmasebinia
Ribosome recycling is a fundamental biological process crucial for cellular health. Defective recycling disrupts ribosome biogenesis and organelle function, particularly in mitochondria, contributing to ribosomopathies, neurodegenerative di...
Athanasios Siametis,George A Garinis
Athanasios Siametis
Persistent genomic instability compromises cellular viability while also triggers non-cell-autonomous responses that drive dysfunction across tissues, contributing to aging. Recent evidence suggests that DNA damage activates secretory progr...
Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life [0.03%]
二核苷酸多聚磷酸在细胞信号转导中的功能和进化：贯穿生命的视角
Gert Bange,Jennifer N Andexer,Henning J Jessen et al.
Gert Bange et al.
Once considered biochemical oddities, dinucleoside polyphosphates such as diadenosine tetraphosphate (Ap4A) are now recognized as conserved signaling molecules involved in essential cellular processes, including stress response, RNA stabili...
Top-Down Coercive Mechanisms and the Major Transitions in Evolution [0.03%]
自上而下的强制机制与生命起源及重大进化跃迁的关系
Javier Suárez,Adrian Stencel,Isobel Ronai
Javier Suárez
We propose that top-down coercive mechanisms have played a role in the origin and maintenance of the Major Transitions in Evolution (MTE). Top-down coercion has potentially been underappreciated due to the lack of a conceptual framework. Th...
The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis [0.03%]
隐秘的建筑师：一氧化氮和植物干细胞稳态中的红氧平衡动力学
Jian Zeng,Xin&#x;Ai Zhao,Jan U Lohmann
Jian Zeng
Plant stem cell homeostasis is a tightly controlled process governed by a complex network of transcription factors, hormones, signaling molecules, and various environmental factors. Among these, nitric oxide (NO) and redox signaling have em...