Equality, Diversity and Inclusivity (EDI) Sandpit: Views on Research Paradigms and the Future of Academia [0.03%]
平等、多样性及包容性（EDI）观点碰撞会：研究范式和学术界未来之见地
Riaz Akhtar,Eric Hill,Paul Gilbert et al.
Riaz Akhtar et al.
In this report, we summarize the outcome of a consultation session held in January 2024 appraising adopted attitudes within scientific research. This Equality, Diversity & Inclusion (EDI) Sandpit was a collaboration between interdisciplinar...
Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH-RH in Teleosts [0.03%]
鱼类FSH-RH的发现揭示了脊椎动物促性腺激素调节的新观点
Daichi Kayo,Shun Kenny Uehara,Muhammad Rahmad Royan et al.
Daichi Kayo et al.
Vertebrate gonadal function is regulated by pituitary gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones are considered to be regulated by hypothalamic factor(s). Since the discovery of gonadotrop...
Biosensors for Detecting Small Rho GTPases: Monitoring Expression and Activation [0.03%]
用于检测小Rho GTP酶的生物传感器：监测表达和激活状态
Nik Yasmin Umaira Hasnizan,Chong Chien Fung,Saw Keat Chuan et al.
Nik Yasmin Umaira Hasnizan et al.
Advanced biosensing technologies, such as Förster resonance energy transfer (FRET) and bioluminescence resonance energy transfer (BRET), have enabled real-time, high-resolution tracking of Rho GTPase activity, surpassing traditional method...
Bhavya R Bhaskar,Shahina Mazumdar,Sruthilaya Dayanandan et al.
Bhavya R Bhaskar et al.
The timely release of chemical messengers is a crucial step in cell-to-cell communication. Does this release occur as a passive diffusion from the donor membrane or it is actively regulated? A series of studies indicated that chemical messe...
Shear Stress as a Danger Signal: Inducing Inflammation and Thrombosis via Mechanosensitive NETosis [0.03%]
剪切应力作为危险信号通过机械敏感受体诱导NETosis介导的炎症和血栓形成
Sara Baratchi,Karlheinz Peter
Sara Baratchi
Neutrophil extracellular traps (NETs)-web-like DNA structures extruded by neutrophils in response to various stimuli, including pathogens, sterile inflammation, and mechanical stress-play a dual role in immunity and disease. While NETs serv...
Anelise N Hutson,Kristy Rochon,Jason A Mears
Anelise N Hutson
Dynamin superfamily proteins (DSPs) are large GTPases that play crucial roles in membrane remodeling processes, including vesicle uptake, mitochondrial fission, and opposing fusion events. Among them, dynamin and dynamin-related protein 1 (...
Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells [0.03%]
初级纤毛的去除：分化细胞中分解的不同途径
Carolyn M Ott,Saikat Mukhopadhyay
Carolyn M Ott
Primary cilia are customized subcellular signaling compartments leveraged to detect signals in diverse physiological contexts. Although prevalent throughout mammalian tissues, primary cilia are not universal. Many non-ciliated cells derive ...
When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination [0.03%]
计时启动：有丝分裂持续时间在细胞命运决定中的作用
Cornelia Sala,Elmar Schiebel
Cornelia Sala
Mitosis is a crucial phase of the cell cycle, during which several mechanisms work together to ensure accurate chromosome segregation and to eliminate defective cells if errors occur. One key mechanism is the spindle assembly checkpoint (SA...