Sundus Siddiqui,Hiba Siddiqui,Emna Riguene et al.
Sundus Siddiqui et al.
Zebrafish (Danio rerio) have become a versatile model in precision medicine, bridging fundamental biology with translational applications. Their optical transparency, rapid development, and high genetic conservation with humans enable real-...
The Allosteric Mechanism of G-Protein-Coupled Receptors is Induced Fit, Not Conformational Selection [0.03%]
G蛋白偶联受体的别构机制是诱导契合而非构象选择
Kazem Asadollahi,Paul R Gooley,Thomas R Weikl
Kazem Asadollahi
The allosteric mechanism of G-protein-coupled receptors (GPCRs) involves a population shift from inactive to active receptor conformations in response to the binding of ligand agonists. Two possible kinetic mechanisms for this population sh...
The Neuroimmune Landscape of the Lysosomal Storage Disorder Sanfilippo Syndrome [0.03%]
桑菲利波综合征的神经免疫景观
Rafael A Badell-Grau,Johannes C M Schlachetzki
Rafael A Badell-Grau
Lysosomal storage disorders (LSDs) such as Sanfilippo syndrome (Mucopolysaccharidosis type III) are characterized by impaired lysosomal degradation due to inherited in lysosomal proteins. This dysfunction leads to the accumulation of undegr...
Anaïs Lamoureux,Emilie Elvira-Matelot,Françoise Porteu et al.
Anaïs Lamoureux et al.
The clonal evolution model provides a framework for understanding the evolution of cancer cells. According to this model, cancer cells accumulate genetic mutations over time, and these mutations are passed down to their descendants, leading...
Direct Protein Degradation: Emerging Tools to Probe Biological Complexity in Mammalian Systems [0.03%]
直接蛋白质降解：探测哺乳动物系统生物学复杂性的新兴工具
Sailasree Rajalekshmi,Kizhakke Mattada Sathyan
Sailasree Rajalekshmi
Conditional degron approaches for acute and reversible protein depletion have become standard tools for studying gene function in cells and model organisms. Traditional gene perturbation methods have advanced gene function studies but are l...
Integrating Astrocytes in the Sleep-Wake Cycle: The Time Is Now [0.03%]
astrocytes在睡眠-觉醒周期中的整合：时机已成熟
Marco Brancaccio
Marco Brancaccio
Astrocytes are emerging as critical regulators of the sleep-wake cycle, actively contributing to both sleep homeostasis and circadian rheostasis. This dual role challenges neuron-centric frameworks that have dominated sleep and circadian bi...
Eukaryogenesis From FECA to LECA: Radical Steps Along the Way [0.03%]
从FECA到LECA的真核生物发生：通向真核细胞进化的决定性步骤
Dave Speijer
Dave Speijer
The characteristics of the last eukaryotic common ancestor (LECA) population and the root of the eukaryotic tree have been coming into focus lately. However, the trajectory taking the host, related to present-day Asgard archaea and the endo...
Cancer Metabolism Meets DNA Repair: The Hidden Link to Therapy Resistance [0.03%]
癌症代谢与DNA修复：隐藏的治疗耐药性链接
Chunzhang Yang
Chunzhang Yang
Cancer cells exhibit reprogrammed metabolic pathways to sustain aggressive phenotypes, including continuous cell division, stemness, invasion, and metastasis. Emerging evidence suggests that these metabolic adaptations profoundly impact DNA...
Cytosolic fMet-Protein Synthesis as Source of Endogenous Ligands for Formyl Peptide Receptors [0.03%]
肽酰基肽作为形式肽配体的胞质内fMet蛋白质合成来源
Chang-Seok Lee,Cheol-Sang Hwang
Chang-Seok Lee
Formyl peptides, exemplified by the synthetic tripeptide formyl-Met-Leu-Phe (fMLF), are well-established ligands for formyl peptide receptors (FPRs), central to neutrophil chemotaxis, and innate immune signaling. Traditionally attributed to...
Multimodal Breathing Control: Pontomedullary Mechanisms and Current Perspectives [0.03%]
多模态呼吸控制：脑桥延髓机制及当前观点
Nathan A Baertsch,Elora Reily,Jonathan Sedano et al.
Nathan A Baertsch et al.
Breathing is a vital, continuous behavior that maintains physiological homeostasis, yet it is also remarkably flexible-modulated by volitional, emotional, and behavioral states. This review highlights recent advances in understanding how di...