Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis [0.03%]
形态发生过程中，平面细胞极性与机械信号转导之间的联系
Ksenia S Egorova,Sergei Y Sokol
Ksenia S Egorova
Mechanical forces provide essential cues for morphogenetic processes during embryonic development. Coordinated orientation of cells in the plane of epithelia, that is known as planar cell polarity (PCP), is also required for morphogenesis. ...
Using Mathematical Modeling of Tumor Metabolism to Predict the Magnitude, Composition, and Hypoxic Interactions of Microenvironment Acidosis [0.03%]
利用肿瘤代谢的数学模型预测微环境酸中毒的强度、组成及低氧相互作用
Alzbeta Hulikova,Pawel Swietach
Alzbeta Hulikova
In well-perfused tissues, interstitial composition resembles capillary plasma. Solid tumors break this norm because cancer cell proliferation outpaces vascular expansion, leading to a diffusion-limited tumor microenvironment (TME) that is n...
License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication [0.03%]
DNA复制的许可机制：真核生物复制起点的许可机制
Victoria Frisbie,Franziska Bleichert
Victoria Frisbie
Accurate and timely genome replication is a universal feature of living organisms and a prerequisite for cell proliferation. In eukaryotes, genomic DNA replication initiates in two steps, origin licensing and origin firing, reflecting the l...
Could Artificial Food Colors Be Sleep Disruptors? A Provocative Hypothesis on Neurobehavioral and Circadian Pathway Interference in Children [0.03%]
人工食品色素会扰乱睡眠吗？一种关于神经行为和昼夜节律通路干扰的发人深省的假说
Bianca Camilo Schimenes,Gustavo A Moreira,Tathiana A Alvarenga et al.
Bianca Camilo Schimenes et al.
We propose a novel hypothesis that artificial food colors (AFCs) may act as sleep disruptors in children by interfering with neurochemical pathways involved in circadian regulation and behavioral stability. Although widely used in ultra-pro...
Zipping up the Synaptonemal Complex: Pathways to Homologous Chromosome Synapsis [0.03%]
同源染色体联会的途径：合成联会复合体
Ariel L Gold,Yumi Kim
Ariel L Gold
The synaptonemal complex (SC), a hallmark of meiosis, is a zipper-like protein assembly that links homologous chromosomes to regulate their recombination and segregation. With its characteristic ladder-like structure bridging paired homolog...
Hybrid Legacies: Evolutionary Consequences of Neandertal Introgression and Implications for Autism [0.03%]
混合遗产：尼安德特人血统的进化后果及其对自闭症的影响
Emily L Casanova,Trenton W Holliday
Emily L Casanova
Recent work has shown that a subset of Neandertal-derived single-nucleotide polymorphisms (SNP) seems to be playing roles in autism susceptibility. We review this exciting research, as well as the known history of human migrations and inter...
Primed to Burst: Corepressors Coordinate Transcriptional Activation and Efficient Switching Between Cell States [0.03%]
预而不发：核心pressor协调转录激活并在细胞状态之间高效切换
Alexander R Leydon,Jennifer L Nemhauser
Alexander R Leydon
Recapitulation of the nuclear auxin response pathway in yeast led to the hypothesis that corepressors prime loci for rapid bursts of transcription. Specifically, the TPL corepressor, which inhibits transcription in the absence of auxin, int...
Beyond Multilevel Selection in Cancer: Rethinking Metastasis Through Selection for Function [0.03%]
超越癌症中的多级选择：通过功能选择重新思考转移性癌
Frédéric Thomas,Antoine M Dujon
Frédéric Thomas
Laplane et al. recently provided a valuable framework for understanding cancer evolution through multilevel selection (MLS), distinguishing between MLS1, where groups differ in persistence based on the traits of their constituent cells but ...
Where, When, and How? Integrating Spatiotemporal Cues in Cell Division [0.03%]
何时、何地、如何？整合细胞分裂中的时空线索
Luca Cirillo,Hradini Konthalapalli,Claudio Alfieri et al.
Luca Cirillo et al.
To an external observer, the goal of cell division is evident from the very shape of the duplicated chromosomes. Cells, however, cannot see-they must proceed by groping in the dark, searching for their own DNA-and a series of sophisticated ...