Eukaryogenesis: Did an Oxidative Crucible Result in Misleading Bioinformatic Analyses? [0.03%]
真核细胞的起源：氧化反应是否导致了误导性的生物信息学分析？
Dave Speijer
Dave Speijer
Recently, Nature published a large-scale analysis ("Dated gene duplications elucidate the evolutionary assembly of eukaryotes" by Christopher Kay and co-workers) that seems to put an end to symbiogenic models for eukaryogenesis. They state ...
Yvonne Lange,Theodore L Steck
Yvonne Lange
A novel model recently proposed by Doktorova et al. challenges current concepts for the molecular organization of the plasma membrane bilayer. It is at odds with previously published research. The model posits that there are far fewer phosp...
Joshua Cuddihy,Yuemin Li,Isobel Fisher et al.
Joshua Cuddihy et al.
The mastery of fire transformed human evolution through advantages spanning diet, behavior, physiology, and ecology. While these benefits are well established, here we highlight a previously overlooked cost - and selective pressure - unique...
Macrophages in the Mammary Gland Stem Cell Niche: A Double-Edged Sword in Tissue Regeneration and Tumor Initiation [0.03%]
巨噬细胞在乳腺干细胞微环境中具有双重刃面：促进组织再生和肿瘤发生
Eunmi Lee,Yibin Kang
Eunmi Lee
Stem cell populations employ cell-intrinsic and niche-mediated mechanisms to preserve long-term self-renewal and regenerative potential. We propose that tumor-initiating cells (TICs) hijack this developmental circuitry to sustain their grow...
The Thing About Neurons [0.03%]
关于神经元的事
Dave Speijer
Dave Speijer
The Host Coral Bleaching Response Viewed Through the Lens of Multi-Omics: Multi-Omics Provides the Tools to Understand the Complex Molecular Basis of Coral Bleaching, Which Can Aid Conservation Efforts [0.03%]
多组学视角下的珊瑚宿主白化响应：多组学为理解复杂的珊瑚白化分子机制及其在保护工作中的作用提供了工具
Debashish Bhattacharya,Shrinivas Nandi,Erin E Chille et al.
Debashish Bhattacharya et al.
We review recent multi-omics analyses of the coral heat stress response to explore the generality of the Oxidative Theory of Coral Bleaching (OTCB), which posits that algal symbiont release is the final act of defense by the coral host to s...
Fat and Dachsous Signaling-Controlling Growth Requires Both Competition and Cooperation: Competitive Interactions at the Cell Cortex Restrict the Ability of an Unusual Protein Complex to Promote Tissue Growth [0.03%]
脂肪和Dachsous信号传导-生长的调控需要竞争与合作：细胞皮层上的竞争性相互作用限制了非同寻常的蛋白质复合物促进组织生长的能力
Hitoshi Matakatsu,Richard G Fehon
Hitoshi Matakatsu
The Hippo signaling pathway plays a key role in organ size control in normal development and tumorigenesis. While many components of this pathway are well understood, its upstream regulation remains unclear. Among the most enigmatic upstrea...
A New Classification Framework to Understand Evolutionary Transitions in Individuality [0.03%]
一种新的分类框架以理解个体性中的进化过渡
Saskia Wilmsen,Christian Kost
Saskia Wilmsen
Life on Earth has evolved as a series of evolutionary transitions, during which lower-level units merged to form a new and more complex higher-level entity. Besides few canonical examples, many life forms exist for which it remains unclear ...
Nucleosome Bundling by Barrier-to-Autointegration Factor: Implications for Its Diverse Functions [0.03%]
屏障自主整合因子介导核小体聚簇作用及其功能多样性分析
Naoki Horikoshi,Hitoshi Kurumizaka
Naoki Horikoshi
In eukaryotic cells, genomic DNA is packaged into chromatin, restricting the access of regulatory proteins and thus regulating key processes such as transcription, replication, recombination, and the repair of DNA. Barrier-to-autointegratio...