Beyond Short Microhomologies: Mismatch-Compatible Pol θ-Mediated DNA Damage Repair [0.03%]
超越短微同源序列：错配兼容型Pol θ介导的DNA损伤修复
Yuzhen Li,Richard D Wood
Yuzhen Li
DNA polymerase θ (Pol θ)-mediated end-joining (TMEJ), one of several pathways for repairing DNA double-strand breaks, is traditionally thought to initiate via anchoring at short, consecutive, and perfectly matched microhomologies (MHs). E...
Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport [0.03%]
以细胞器和微管协同迁移作为定向运输机制的一种方式及其受电机理研究
Chuying Zhou,Mineko Kengaku
Chuying Zhou
Intracellular cargo transport relies on a microtubule (MT) network and its molecular motors, dynein and kinesin. While conventional models emphasize motor-driven cargo movement along stationary MT tracks, emerging evidence suggests that dyn...
Host Genetic Regulation of Stem Cell-Virus Interactions in Human Health [0.03%]
人类健康状况下干细胞与病毒相互作用的宿主基因调控
Alexios-Fotios A Mentis,Athanasios Kossyvakis,Dimitrios Chatzidimitriou
Alexios-Fotios A Mentis
The interactions between human viruses and human stem cells may differ from those with differentiated cells. These differences may arise through heterogeneous intercellular mechanisms and responses to specific infectious agents, resulting i...
Vimentin Intermediate Filaments: A Paradigm Shift From Static Structure to Dynamic Cytoplasmic Network [0.03%]
波形蛋白中间纤维：从静态结构到动态胞质网络的范式转变
Bhuvanasundar Renganathan,Stephen A Adam,Vladimir I Gelfand
Bhuvanasundar Renganathan
Recent advances in live-cell imaging, super-resolution microscopy, labeling techniques and cryo-electron microscopy reveal vimentin intermediate filaments (VIFs) as adaptable polymers that couple mechanical stability with rapid remodeling. ...
Stefan Linquist,Tyler A Elliott,Stefan C Kremer et al.
Stefan Linquist et al.
Recent discoveries of transposable element (TE) activity in the octopus genome suggest, to some, that these "jumping genes" facilitated the evolution of cephalopod brains and possibly contribute to cognitive flexibility in these animals. In...
Kuheli Biswas,Hanna Salman,Naama Brenner
Kuheli Biswas
Biological systems maintain homeostasis, ensuring stability in the face of internal and external perturbations and counteracting stochastic noise. Traditionally, this is understood through the lens of control mechanisms designed to offset v...
Mathias F Wernet,Marion Silies
Mathias F Wernet
Visual systems appear like homogenous structures, where identical functional units repeat themselves across the eye. This architecture is thought to ensure a uniform sampling of the surrounding environment. Furthermore, anatomically and fun...
Dave Speijer
Dave Speijer
Natalia Bernardes,Yuh Min Chook
Natalia Bernardes
The separation of DNA-based processes from cytoplasmic protein synthesis demands precise and effective nuclear import of histones and chromatin regulators. Because histones are highly basic and aggregation-prone, their proper folding, seque...
The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease [0.03%]
自身免疫性疾病中中枢神经系统的脑膜和滑膜的免疫学结构的相似性
Mohamed Reda Fazazi,Manu Rangachari
Mohamed Reda Fazazi
Autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA) involve complex interactions between local tissues and the immune system. Here, we highlight the immunological parallels between the central nervous system (C...