Could the Phenotypic Outcomes of Genetic Variability in Cells Operating in Mechanically Dynamic Environments be Influenced by a Disrupted "Cell-ECM" Relationship? Using Cystic Fibrosis and Marfan Syndrome as an Example [0.03%]
细胞基因多态性在操作机械动力环境中的表型结果是否可能受到破坏的“细胞-基质”关系的影响？以囊性纤维化和马凡氏综合征为例
David A Hart
David A Hart
Diseases due to mutations in essential molecules can involve tissues functioning in very different environments, with some in mechanically active environments. Diseases arising from mutations in a single molecule, such as the CFTR in cystic...
Mechanisms Underlying the Initiation and Termination of Collective Cell Migration: Perspectives for Understanding Development and Cancer Metastasis [0.03%]
集体细胞迁移启动与终止的机制：关于发育和癌症转移的新视野
Guangxia Miao
Guangxia Miao
Collective cell migration is fundamental to developmental processes and disease progression. Despite extensive study, the field lacks a unifying framework for how collective cells initiate and terminate their migration. While these processe...
A Master Conductor: How the SIFamide Neuropeptide System Orchestrates Behavioral State in Drosophila [0.03%]
SIFamide神经肽系统在果蝇行为状态调控中的作用机制研究
Tianmu Zhang,Woo Jae Kim
Tianmu Zhang
How does the brain prioritize competing drives like hunger, sleep, and mating? In Drosophila, the neuropeptide SIFamide (SIFa) has emerged as a central coordinator of these behavioral states. This commentary synthesizes recent findings, hig...
An Increase in Animal Diversity was Facilitated by Ecologically-Driven Brain Complexity Throughout the Cambrian [0.03%]
生态驱动的脑复杂度在寒武纪期间推动动物多样性的增加
Ariel D Chipman
Ariel D Chipman
The Cambrian Explosion is often seen as a singular event requiring an explanation. In fact, it is better represented as a cascade of linked events, each with numerous causes. The iconic middle Cambrian fauna, represented by sites such as th...
Polarization as a Process: The Potential of Process Ontology for Understanding Cellular Symmetry Breaking [0.03%]
作为过程的极化：过程本体论在理解细胞对称性破缺方面的潜力
Marieke M Glazenburg,Liedewij Laan
Marieke M Glazenburg
Research in molecular cell biology has typically been focused on identifying specific genes and proteins responsible for cellular phenomena. However, it is increasingly recognized that the function of many biomolecules is variable and conte...
Armando Aranda-Anzaldo,Myrna A R Dent,Alejandro Martínez-Gómez et al.
Armando Aranda-Anzaldo et al.
Peto's paradox (Pp) results from the evidence that in mammals there is no obvious positive correlation between body size, lifespan, and cancer incidence. Posing the question of which mechanisms are responsible for this. Comparative studies ...
Metal-Enhanced Fluorescence for the Biologist's Cellular Imaging Toolkit: Design Principles and Recent Applications [0.03%]
用于生物学家细胞成像工具包的金属增强荧光：设计原则和最新应用
Gregory K Hodgson,Stefania Impellizzeri
Gregory K Hodgson
Fluorescence microscopy is essential in modern cell biology but remains constrained by photobleaching, autofluorescence, and the intrinsic quantum yields of emitters. Metal-enhanced fluorescence (MEF) is a photophysical phenomenon in which ...
Morphogen Gradients as Drivers of Mosaicism During Early Human Development [0.03%]
胚胎发育早期形态蛋白梯度诱导镶嵌型模式形成机制研究
Sergio P Acebrón,Janina Hattemer,Tobias Rausch et al.
Sergio P Acebrón et al.
WNT, BMP, FGF, and Nodal signalling gradients drive naive to primed epiblast transitions and primitive endoderm specification, as well as subsequent gastrulation of the implanted embryo. Recently, these pathways were shown to control a sign...
Diverse Scaffolds Facilitate NLRP3 Clustering and Inflammasome Formation in Response to Perturbations in Cell Homeostasis [0.03%]
多种支架促进NLRP3聚集和细胞稳态扰动引起的炎性体形成
Elvira Boršić-Mlinarič,Iva Hafner-Bratkovič
Elvira Boršić-Mlinarič
A central component of innate immunity, the NLRP3 inflammasome is a multiprotein complex formed in response to a chemically and morphologically diverse spectrum of stimuli. Despite extensive investigation, no single ligand or signal has eme...
Dynamic Allostery in T Cell Receptor Specificity: A Role for Peptides and MHC Polymorphisms in Allosterically Tuning Immune Recognition [0.03%]
动态别构效应与T细胞受体的特异性之间的关系：肽和主要组织相容性复合物多态性在别构调节免疫识别中的作用
Bassant Eldaly,Brian M Baker
Bassant Eldaly
T cell receptor (TCR) recognition of peptide/MHC complexes is fundamental for adaptive immunity. Many studies have described the importance of peptide/MHC motion or dynamics in TCR recognition. A role for dynamics in recognition intersects ...